MUSC Center for Oral Health Research

在Cobre第三阶段的支持下，MUSC口腔健康研究中心(COHR)将完成向长期可持续性的过渡，成为具有全国竞争力的口腔健康多学科研究项目。COHR旨在扩大MUSC口腔和颅面研究的资助研究人员的临界质量，并加强作为平台的科学核心资源，以提高我们教师成功竞争NIH资金的能力。到目前为止，联合国人权事务高级专员办事处共指导了28名初级调查人员，其中17人获得晋升，3人获得终身教职；28人中有23人留在了我们机构。作为一个整体，他们发表了250多篇同行评议的论文和摘要。他们总共得到了50笔校外赠款的支持，其中包括24笔他们担任私人助理或关键人员的国立卫生研究院赠款。这项建议的主要组成部分是：A)提供组织、协调、财政和问责职能的行政核心；B)实验室核心(L-COHR)通过四个互动设施--灵生动物研究设施、矿化组织设施、口腔癌症研究设施和激光显微解剖设施--提供服务；C)临床核心(C-COHR)促进临床和转化性研究，并通过基于社区的参与性研究激励研究发现；以及D)试点项目和可行性项目计划，为试点研究提供支持，以促进利用中心资源、人员和设施的研究项目，并促进与COHR成员的互动。COHR也有一个由NIH资助的研究培训部分(T-COHR)，作为对这一提议的补充。COHR的发展和活动推动了牙科医学院的重大文化转变，并促进了校园和国家层面对口腔健康研究的认可。研究发现和拨款的成功为牙科医学院的研究创造了一个互动的、支持性的环境。因此，口腔健康研究中心处于长期成功的战略地位，是研究人员开发新技术、疗法和干预措施以提高南卡罗来纳州和美国人民口腔健康的关键资源。

With Phase III COBRE support, the MUSC Center for Oral Health Research (COHR) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in oral health. The COHR was conceived to expand the critical mass of funded investigators at MUSC in oral and craniofacial research and to enhance scientific core resources that serve as platforms to increase the capacity of our faculty to compete successfully for NIH funding. The COHR has mentored a total of 28 junior investigators to date, of which 17 have been promoted and 3 have earned tenure; 23 of the 28 have been retained at our institution. As a group, they have published more than 250 peer-reviewed papers and abstracts. They have received support from a total of 50 extramural grants, including 24 NIH grants on which they serve as PI or Key Personnel. The major components of this proposal are: A) The Administrative Core providing organizational, coordinating, fiscal and accountability functions; B) The Laboratory Core (L-COHR) providing services through four interactive facilities--the Gnotobiotic Animal Research Facility, Mineralized Tissue Facility, Oral Cancer Research Facility, and Laser Capture Microdissection Facility; C) The Clinical Core (C-COHR) fostering clinical and translational research and stimulating research discoveries through community-based participatory research; and D) The Pilot Project and Feasibility Projects Program providing support for pilot studies to foster research projects that utilize Center resources, personnel and facilities and facilitate interaction with COHR members. The COHR also has an NIH-funded research training component (T-COHR) that complements this proposal. The COHR's growth and activities have fueled a major cultural shift in the College of Dental Medicine and fostered recognition for oral health research at both campus and national levels. Research discoveries and grant success have created an interactive, supportive environment for research in the College of Dental Medicine. Thus, the Center for Oral Health Research is strategically positioned for long-term success as a critical resource for investigators developing new technologies, therapeutics and interventions to enhance the oral health of people in South Carolina and the United States.