Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure

有氧运动、神经营养素以及海马功能和结构的功能磁共振成像

• 批准号: 8639187
• 负责人: Karin Schon
• 金额: $ 24.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8639187
• 关键词: Adult; Aerobic; Aerobic Exercise; Aging; Alzheimer' s Disease; Animal Experimentation; Animal Model; Area; Behavior; Behavioral; Blood; Brain; Brain-Derived Neurotrophic Factor; Cardiovascular system; Clinical; Clinical Psychology; Clinical Trials Design; Cognition; Cognitive; Control Groups; Cross-Sectional Studies; Doctor of Medicine; Doctor of Philosophy; Elderly; Exercise; Exercise Physiology; Face; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Grant; Health; Hippocampus (Brain); Human; Image; Impaired cognition; Individual; Intervention; Knowledge; Link; Longevity; Magnetic Resonance Imaging; Measurement; Measures; Medial; Memory; Mentors; Methods; Movement Disorders; Names; Neuroanatomy; Neurology; Neuropsychology; Neurorehabilitation; Outcome; Outcome Measure; Paired-Associate Learning; Pathway interactions; Performance; Phase; Pre-Post Tests; Prefrontal Cortex; Randomized; Recruitment Activity; Research; Resolution; Role; Sampling; Scanning; Scientist; Serum; Short-Term Memory; Structure; Task Performances; Temporal Lobe; Testing; Thick; Training; Weight; Work; base; behavior test; career; cognitive neuroscience; cost; design; fitness; flexibility; healthy aging; improved; interest; long term memory; memory recognition; neuroimaging; neuropsychological; neurotrophic factor; physical conditioning; primary outcome; professor; programs; research study; sedentary; young adult

PROJECT SUMMARY/ABSTRACT The research proposed in this Pathways grant identifies and seeks to fill a current gap in knowledge regarding the relationship between aerobic exercise and cardiovascular fitness and functional and structural brain health in humans. The proposed human neuroimaging studies build upon a large body of existing animal research, and aim to extend this work to humans. The candidate is interested in establishing an independent research career in which she can study the effects of aerobic exercise and cardiovascular fitness on cognition and brain health in humans across the lifespan. The candidate's past and current research has included functional Magnetic Resonance Imaging (fMRI) studies of interactions between working memory and long-term memory and the role of the medial temporal lobes (including the hippocampus) and prefrontal cortex in working memory. The overall goal of this proposal is to prepare the candidate for a career as an independent scientist in translational cognitive neuroscience. Mentors include Dr. Chantal E. Stern, D.Phil., an expert in the cognitive neuroimaging of memory, Dr. Robert C. Wagenaar, Ph.D., a professor of exercise physiology and neurorehabilitation who is known for his work on movement disorders, Dr. Andrew E. Budson, M.D., an expert in cognitive and behavioral neurology, who is known for his work on cognitive dysfunction and memory dysfunction in Alzheimer's Disease, and Dr. Alice Cronin-Golomb, Ph.D. a professor of clinical psychology and an expert in the neuropsychology of aging. The goals of the research plan are to 1) establish a link between aerobic exercise, cardiovascular fitness, the functional neuroanatomy of hippocampal-dependent memory, and a neurotrophin, the Brain-Derived Neurotrophic Factor (BDNF) in humans using two memory tasks and fMRI (Specific Aim #1), 2) investigate whether a 12-week aerobic exercise intervention in healthy young and older sedentary adults is associated with an improvement in memory task performance, increased serum BDNF levels, and enhanced task-related hippocampal activity using fMRI and a pretest-posttest randomized control group design (Specific Aim #2), and 3) investigate whether the same aerobic exercise intervention in healthy young and older sedentary individuals results in increased volume in the hippocampus and/or hippocampal subfields, and cortical thickness in other brain areas using structural MRI and morphometric methods. The candidate will acquire essential training in exercise physiology and neurorehabilitation, geriatric neurology, clinical neuropsychological assessment, morphometric analyses of structural MRI images, and in clinical trial design. The project will enable the candidate to establish an externally funded research program in translational cognitive neuroscience. Aerobic exercise may be an effective and low-cost intervention resulting in healthy aging by promoting not only physical health, but also brain health. Regular moderate intensity aerobic exercise may have neuroprotective effects throughout the lifespan.

项目总结/文摘