Air Quality and Reproductive Health

空气质量和生殖健康

• 批准号: 8736947
• 负责人: Pauline Mendola
• 金额: $ 45.42万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8736947
• 关键词: Address; Affect; Age; Air; Air Pollutants; Air Pollution; Asthma; Cardiovascular Pregnancy Complications; Cardiovascular system; Cessation of life; Child; Chronic Disease; Communities; Complex; Data; Exposure to; Fetal Growth; Fetal Growth Retardation; Gestational Diabetes; Health; Hormones; Infant Mortality; Literature; Low Birth Weight Infant; Measures; Modeling; Monitor; Morbidity - disease rate; Newborn Infant; Outcome; Ovarian; Ovulation; Oxidants; Ozone; Particulate Matter; Population; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnant Women; Premature Birth; Reproductive Health; Research; Risk; Role; Seminal fluid; Subgroup; Testing; Woman; adverse outcome; air monitoring; base; chemical property; data reduction; interest; meter; mortality; novel; pollutant; premature; reproductive; secondary outcome; trafficking

Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter in 2005. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to menstrual/ovarian function and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment of hormone fluctuations associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and hormone measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models. Secondary outcomes, including cardiovascular complications in labor/delivery and gestational diabetes are also addressed in relation to air quality.

空气污染物导致美国发病率和死亡率增加，2005年估计有135，000人因臭氧和2.5微米/立方米的颗粒物而过早死亡。 空气质量差也与不良妊娠结果有关，包括早产、胎儿生长受限/出生体重低和婴儿死亡率。 该项目研究了与月经/卵巢功能和分娩/分娩数据有关的空气质量措施，以补充与空气污染物暴露相关的生殖健康结果的文献。 特别令人感兴趣的是哮喘妇女的妊娠结局，她们可能代表了空气质量差和哮喘相关健康影响的综合影响以及与暴露于交通和监测空气质量相关的激素波动的新评估的脆弱亚组。 大多数关于空气污染和妊娠结局的先前研究都是基于生命记录数据。 该项目提供了一个机会，可以在广泛的国家层面上评估分娩和分娩并发症以及以前未研究过的激素措施。 暴露评估基于社区多尺度空气质量模型。 次要结果，包括分娩/分娩中的心血管并发症和妊娠糖尿病也与空气质量有关。