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Air Quality and Reproductive Health

空气质量和生殖健康

基本信息

批准号：
10266526
负责人：
Pauline Mendola
金额：
$ 39.19万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10266526
关键词：
Address Admission activity Affect Age Air Air Pollutants Air Pollution Asthma Autoimmune Diseases Cardiovascular system Cessation of life Child Chronic Disease Communities Complex Congenital Abnormality Data Environment Exposure to Fertility Fetal Growth Fetal Growth Retardation Gestational Diabetes Health Infant Mortality Labor Complications Literature Low Birth Weight Infant Measures Modeling Monitor Morbidity - disease rate Newborn Infant Outcome Oxidants Ozone Paper Particulate Matter Population Pre-Eclampsia Pregnancy Complications Pregnancy Outcome Pregnant Women Premature Birth Reproductive Health Research Risk Role Seminal fluid Subgroup Temperature Testing Woman adverse outcome adverse pregnancy outcome air monitoring base delivery complications early pregnancy loss interest meter mortality novel pollutant pregnancy hypertension premature prospective reproductive secondary outcome stillbirth time-to-pregnancy

项目摘要

Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter each year. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to fertility and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment prospective time-to-pregnancy associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and fertility measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models. Secondary outcomes, including cardiovascular complications in labor/delivery, gestational diabetes, and birth defects are also addressed in relation to air quality and ambient temperature.

空气污染物导致美国发病率和死亡率增加，估计每年有 135,000 人因臭氧和 2.5 微米/立方米颗粒物过早死亡。空气质量差还与不良妊娠结局有关，包括早产、胎儿生长受限/低出生体重和婴儿死亡率。该项目研究了与生育率和分娩数据相关的空气质量指标，以添加到与空气污染物暴露相关的生殖健康结果的文献中。特别令人感兴趣的是患有哮喘的女性的妊娠结局，由于空气质量差和哮喘相关的健康影响的综合影响，她们可能代表了一个脆弱的亚群，以及与交通暴露和监测的空气质量相关的新的预期怀孕时间评估。大多数先前关于空气污染和妊娠结局的研究都是基于重要记录数据。该项目提供了一个机会，可以在全国范围内评估分娩并发症以及以前未研究过的生育措施。暴露评估基于社区多尺度空气质量模型。次要结局，包括临产/分娩时的心血管并发症、妊娠糖尿病和出生缺陷，也与空气质量和环境温度有关。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Air pollution exposure during pregnancy: maternal asthma and neonatal respiratory outcomes.

DOI：
10.1016/j.annepidem.2018.06.003
发表时间：
2018-09
期刊：
Annals of epidemiology
影响因子：
5.6
作者：
Seeni I;Ha S;Nobles C;Liu D;Sherman S;Mendola P
通讯作者：
Mendola P

Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth.

DOI：
10.3390/ijerph14070731
发表时间：
2017-07-06
期刊：
International journal of environmental research and public health
影响因子：
0
作者：
Mendola P;Ha S;Pollack AZ;Zhu Y;Seeni I;Kim SS;Sherman S;Liu D
通讯作者：
Liu D

Estimating population exposure to ambient polycyclic aromatic hydrocarbon in the United States - Part I: Model development and evaluation.

DOI：
10.1016/j.envint.2016.12.002
发表时间：
2017-03
期刊：
Environment international
影响因子：
11.8
作者：
Zhang J;Li J;Wang P;Chen G;Mendola P;Sherman S;Ying Q
通讯作者：
Ying Q

Air pollution and cardiovascular events at labor and delivery: a case-crossover analysis.

临产时的空气污染和心血管事件：病例交叉分析。

DOI：
10.1016/j.annepidem.2017.05.007
发表时间：
2017
期刊：
Annals of epidemiology
影响因子：
5.6
作者：
Ha,Sandie;Männistö,Tuija;Liu,Danping;Sherman,Seth;Ying,Qi;Mendola,Pauline
通讯作者：
Mendola,Pauline

Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects.

DOI：
10.1016/j.envres.2015.06.002
发表时间：
2015-07
期刊：
ENVIRONMENTAL RESEARCH
影响因子：
8.3
作者：
Zhu, Yeyi;Zhang, Cuilin;Liu, Danping;Grantz, Katherine L.;Wallace, Maeve;Mendola, Pauline
通讯作者：
Mendola, Pauline