Training in Cellular Signaling in the Cardiovascular System

描述(由申请人提供)： 我们的计划的主要目标仍然是为新一代科学家提供一个互动和集成的环境，使他们能够通过从分子到细胞再到组织再到生物体水平的机制的连续研究。该计划包括38名培训员和10个系，其主题是培训现代方法的应用，包括基因组学、蛋白质组学和蛋白质化学、结构和分子动力学、细胞力学和电生理学、计算生物学、系统生理学，包括对心脏和血管的动态和活动的了解。该计划强调将研究成果转化为疾病的诊断、治疗和预防。培训地点包括伊利诺伊大学芝加哥分校(UIC)和拉什大学，后者提供了独特和多样化的培训环境。重点领域包括内分泌、旁分泌、自分泌和机械信号、电化学耦合、通道、转运体和受体、化学-机械耦合结构生物学、蛋白质组学、信号转导、基因组学、基因调控、翻译和组装，以及信号和系统生物学的整合。该方案在为受训者提供包括多次座谈和研讨会在内的环境以及培训人员个人或受训者群体之间的互动和协同方面有着良好的历史。博士前候选人在UIC医学研究生教育(GEMS)项目的核心课程中成功完成一年的研究生学习后进入该项目。他们继续在生物工程、生理学和生物物理、生物化学和分子生物学、细胞生物学和药理学等专业领域进行培训。博士前课程还包括相关领域的必修高级研究生课程，包括干细胞生物学、质谱学和蛋白质组学、信息学、控制论、系统和计算生物学，以及科学探究的技术、概念和策略。这些课程包括评估机会以及写作和陈述技能培训。对博士后实习生的培训包括根据他们的职业目标量身定做的两到三年计划。

DESCRIPTION (provided by applicant): Our program continues to have as its major objective to provide an interactive and Integrated environment for the generation of scientists with the ability to move through a continuum of investigations from molecular to cellular to tissue to organism level mechanisms. A theme of the program, which includes 38 trainers and 10 departments is training in the application of modern approaches including genomics, proteomics and protein chemistry, structure, and molecular dynamics, cellular mechanics and electrophysiology, computational biology, systems physiology including an understanding of the dynamics and activity of the heart and blood vessels. The program emphasizes translation of findings to the diagnosis, treatment, and prevention of disease. Sites of training include the University of Illinois at Chicago (UIC) and Rush University, which provides a unique and diverse training environment. Focus areas include endocrine, paracrine, autocrine, and mechanical signaling, electro-chemical coupling, channels, transporters and receptors, chemo-mechanical coupling structural biology, proteomics, signal transduction, genomics, gene regulation, translation and assembly, and Integration of signaling and systems biology. The program has a demonstrated history of providing an environment for trainees that includes multiple colloquia and seminars, and interactions and synergy among groups of trainers working individual or groups of trainees. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS) Program. They continue training in specialized areas including Bioengineering, Physiology and Biopphysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacolgy. The pre-doctoral curriculum is supplemented by required upper level graduate courses in areas of interest including Stem Cell Biology, Mass Spectrometry and Proteomics, Informatics, Control Theory, Systems and Computational Biology, and Techniques, Concepts, and Strategies of Scientific Enquiry. These courses include opportunities for evaluation and training in writing and presentation skills. The training of post-doctoral trainees includes two to three year programs tailored to their career objectives.