Training in Cellular Signaling in the Cardiovascular System

描述（由申请人提供）： 我们的计划继续作为其主要目标，为一代科学家提供一个互动和综合的环境，能够通过从分子到细胞到组织到生物体水平机制的连续调查。该计划的一个主题，其中包括38名培训师和10个部门是培训现代方法的应用，包括基因组学，蛋白质组学和蛋白质化学，结构和分子动力学，细胞力学和电生理学，计算生物学，系统生理学，包括对心脏和血管的动力学和活动的理解。该计划强调将发现转化为疾病的诊断，治疗和预防。培训地点包括伊利诺伊大学芝加哥分校（UIC）和拉什大学，这提供了一个独特的和多样化的培训环境。重点领域包括内分泌，旁分泌，自分泌和机械信号，电化学耦合，通道，转运蛋白和受体，化学机械耦合结构生物学，蛋白质组学，信号转导，基因组学，基因调控，翻译和组装，以及信号和系统生物学的整合。该计划具有为学员提供环境的历史，包括多个座谈会和研讨会，以及培训师个人或学员团体之间的互动和协同作用。博士前候选人在UIC医学科学研究生教育（GEMS）计划的核心课程研究生学习成功一年后进入该计划。他们继续在专业领域的培训，包括生物工程，生理学和生物物理学，生物化学和分子生物学，细胞生物学和药理学。博士前课程由所需的上层研究生课程补充，包括干细胞生物学，质谱和蛋白质组学，信息学，控制理论，系统和计算生物学，以及技术，概念和科学调查策略。这些课程包括写作和演讲技巧的评价和培训机会。博士后培训人员的培训包括针对其职业目标的两到三年计划。

DESCRIPTION (provided by applicant): Our program continues to have as its major objective to provide an interactive and Integrated environment for the generation of scientists with the ability to move through a continuum of investigations from molecular to cellular to tissue to organism level mechanisms. A theme of the program, which includes 38 trainers and 10 departments is training in the application of modern approaches including genomics, proteomics and protein chemistry, structure, and molecular dynamics, cellular mechanics and electrophysiology, computational biology, systems physiology including an understanding of the dynamics and activity of the heart and blood vessels. The program emphasizes translation of findings to the diagnosis, treatment, and prevention of disease. Sites of training include the University of Illinois at Chicago (UIC) and Rush University, which provides a unique and diverse training environment. Focus areas include endocrine, paracrine, autocrine, and mechanical signaling, electro-chemical coupling, channels, transporters and receptors, chemo-mechanical coupling structural biology, proteomics, signal transduction, genomics, gene regulation, translation and assembly, and Integration of signaling and systems biology. The program has a demonstrated history of providing an environment for trainees that includes multiple colloquia and seminars, and interactions and synergy among groups of trainers working individual or groups of trainees. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS) Program. They continue training in specialized areas including Bioengineering, Physiology and Biopphysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacolgy. The pre-doctoral curriculum is supplemented by required upper level graduate courses in areas of interest including Stem Cell Biology, Mass Spectrometry and Proteomics, Informatics, Control Theory, Systems and Computational Biology, and Techniques, Concepts, and Strategies of Scientific Enquiry. These courses include opportunities for evaluation and training in writing and presentation skills. The training of post-doctoral trainees includes two to three year programs tailored to their career objectives.