Metabolomic profiling in the prediction of Gestational Diabetes Mellitus

代谢组学分析在妊娠糖尿病预测中的应用

• 批准号: 8536804
• 负责人: Rhonda Bentley-Lewis
• 金额: $ 15.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8536804
• 关键词: Aromatic Amino Acids; Behavior Therapy; Biological Markers; Birth trauma; Carbohydrates; Cesarean section; Cohort Studies; Development; Diabetes Mellitus; Diabetes prevention; Diagnostic; Discipline of obstetrics; Discrimination; Early identification; Emerging Technologies; Enrollment; Epidemic; Ethnic Origin; Family history of; First Pregnancy Trimester; Functional disorder; General Hospitals; Gestational Diabetes; Incidence; Intervention; Intervention Studies; Investigation; Isoleucine; Leucine; Massachusetts; Metformin; Modeling; Mothers; Neonatal; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Placebos; Population; Population Study; Pregnancy; Prevalence; Prevention strategy; Public Health; Race; Recording of previous events; Risk; Risk Factors; System; Technology; Tyrosine; Valine; Weight; Woman; advanced maternal age; biological systems; cohort; diabetes prevention program; effective therapy; improved; insulin sensitivity; lifestyle intervention; metabolomics; modifiable risk; novel; offspring; prevent; therapy design; weight loss intervention

DESCRIPTION (provided by applicant): Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the U.S. However, the epidemics of obesity and diabetes, as well as revised GDM diagnostic criteria, are dramatically increasing the prevalence of GDM, as high as 18% of pregnancies according to some estimates. This increasing prevalence is noteworthy because of the concomitant risk for adverse sequelae, not only in the peripartum period, such as increased rates of caesarean section delivery and neonatal birth injury, but also subsequent to pregnancy, including increased risk for type 2 diabetes mellitus (T2DM) for both mother and offspring. Early identification of women at increased risk for GDM would provide the opportunity for the development of targeted GDM and T2DM risk prevention strategies. Our proposal capitalizes on our expertise in emerging technologies, as well as our existing study populations, to further characterize women at increased risk for developing GDM and T2DM. Our Specific Aim 1 will examine a cohort of women followed during pregnancy for the development of GDM. Our Specific Aims 2-4 will examine the cohort of women within the Diabetes Prevention Program (DPP) with a history of GDM for the development of T2DM while examining the effects of study intervention and race on the outcome.

描述（由申请人提供）：妊娠期糖尿病 (GDM) 使美国约 7% 的妊娠变得复杂。然而，肥胖和糖尿病的流行以及 GDM 诊断标准的修订，正在急剧增加 GDM 的患病率，根据一些估计，GDM 的患病率高达 18%。这种不断增加的患病率值得注意，因为随之而来的不良后遗症风险不仅在围产期，例如剖腹产和新生儿产伤率增加，而且在怀孕后也存在，包括母亲和后代患 2 型糖尿病 (T2DM) 的风险增加。及早识别 GDM 风险增加的女性将为制定有针对性的 GDM 和 T2DM 风险预防策略提供机会。我们的提案利用了我们在新兴技术方面的专业知识以及我们现有的研究人群，以进一步描述罹患 GDM 和 T2DM 风险较高的女性的特征。我们的具体目标 1 将检查一组在怀孕期间跟踪的妇女是否患有 GDM。我们的具体目标 2-4 将检查糖尿病预防计划 (DPP) 内有 GDM 病史的女性群体是否发展为 T2DM，同时检查研究干预和种族对结果的影响。