权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Metabolomic profiling in the prediction of Gestational Diabetes Mellitus

代谢组学分析在妊娠糖尿病预测中的应用

基本信息

批准号：
8725653
负责人：
Rhonda Bentley-Lewis
金额：
$ 15.82万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8725653
关键词：
Aromatic Amino Acids Behavior Therapy Biological Markers Birth trauma Carbohydrates Cesarean section Cohort Studies Development Diabetes Mellitus Diabetes prevention Diagnostic Discipline of obstetrics Discrimination Early identification Emerging Technologies Enrollment Epidemic Ethnic Origin Family history of First Pregnancy Trimester Functional disorder General Hospitals Gestational Diabetes Incidence Intervention Intervention Studies Investigation Isoleucine Leucine Massachusetts Metformin Modeling Mothers Neonatal Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Placebos Population Population Study Pregnancy Prevalence Prevention strategy Public Health Race Recording of previous events Risk Risk Factors System Technology Tyrosine Valine Weight Woman advanced maternal age biological systems cohort diabetes prevention program effective therapy improved insulin sensitivity lifestyle intervention metabolomics modifiable risk novel offspring prevent therapy design weight loss intervention

项目摘要

DESCRIPTION (provided by applicant): Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the U.S. However, the epidemics of obesity and diabetes, as well as revised GDM diagnostic criteria, are dramatically increasing the prevalence of GDM, as high as 18% of pregnancies according to some estimates. This increasing prevalence is noteworthy because of the concomitant risk for adverse sequelae, not only in the peripartum period, such as increased rates of caesarean section delivery and neonatal birth injury, but also subsequent to pregnancy, including increased risk for type 2 diabetes mellitus (T2DM) for both mother and offspring. Early identification of women at increased risk for GDM would provide the opportunity for the development of targeted GDM and T2DM risk prevention strategies. Our proposal capitalizes on our expertise in emerging technologies, as well as our existing study populations, to further characterize women at increased risk for developing GDM and T2DM. Our Specific Aim 1 will examine a cohort of women followed during pregnancy for the development of GDM. Our Specific Aims 2-4 will examine the cohort of women within the Diabetes Prevention Program (DPP) with a history of GDM for the development of T2DM while examining the effects of study intervention and race on the outcome.

描述（由申请人提供）：在美国，妊娠期糖尿病（GDM）使约7%的妊娠并发症。然而，肥胖和糖尿病的流行以及修订的GDM诊断标准显著增加了GDM的患病率，根据一些估计，高达18%的妊娠。值得注意的是，这种患病率的增加伴随着不良后遗症的风险，不仅在围产期，如剖腹产和新生儿出生损伤的发生率增加，而且在妊娠后，包括母亲和后代患2型糖尿病（T2 DM）的风险增加。早期识别GDM风险增加的妇女将为制定有针对性的GDM和T2 DM风险预防策略提供机会。我们的建议利用我们在新兴技术方面的专业知识，以及我们现有的研究人群，以进一步描述女性患GDM和T2 DM风险增加的特征。我们的具体目标1将检查一组妇女在怀孕期间跟踪GDM的发展。我们的具体目标2-4将检查糖尿病预防计划（DPP）中有GDM病史的女性队列是否发生T2 DM，同时检查研究干预和种族对结局的影响。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A systematic review of placental pathology in maternal diabetes mellitus.

DOI：
10.1016/j.placenta.2014.11.021
发表时间：
2015-02
期刊：
PLACENTA
影响因子：
3.8
作者：
Huynh, J.;Dawson, D.;Roberts, D.;Bentley-Lewis, R.
通讯作者：
Bentley-Lewis, R.

Metabolomic profiling in the prediction of gestational diabetes mellitus.

妊娠糖尿病预测中的代谢组分析。

DOI：
10.1007/s00125-015-3553-4
发表时间：
2015-06
期刊：
DIABETOLOGIA
影响因子：
8.2
作者：
Bentley-Lewis, Rhonda;Huynh, Jennifer;Xiong, Grace;Lee, Hang;Wenger, Julia;Clish, Clary;Nathan, David;Thadhani, Ravi;Gerszten, Robert
通讯作者：
Gerszten, Robert

A systematic review of metabolite profiling in gestational diabetes mellitus.