Metabolomic profiling in the prediction of Gestational Diabetes Mellitus

代谢组学分析在妊娠糖尿病预测中的应用

• 批准号: 8359459
• 负责人: Rhonda Bentley-Lewis
• 金额: $ 16.5万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359459
• 关键词: Aromatic Amino Acids; Behavior Therapy; Biological Markers; Birth trauma; Carbohydrates; Cesarean section; Cohort Studies; Development; Diabetes Mellitus; Diabetes prevention; Diagnostic; Discipline of obstetrics; Discrimination; Early identification; Emerging Technologies; Enrollment; Epidemic; Ethnic Origin; Family history of; First Pregnancy Trimester; Functional disorder; General Hospitals; Gestational Diabetes; Incidence; Intervention; Intervention Studies; Investigation; Isoleucine; Leucine; Massachusetts; Metformin; Modeling; Mothers; Neonatal; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Placebos; Population; Population Study; Pregnancy; Prevalence; Prevention strategy; Public Health; Race; Recording of previous events; Risk; Risk Factors; System; Technology; Tyrosine; Valine; Weight; Woman; advanced maternal age; biological systems; cohort; diabetes prevention program; effective therapy; improved; insulin sensitivity; lifestyle intervention; metabolomics; modifiable risk; novel; offspring; prevent; therapy design; weight loss intervention

DESCRIPTION (provided by applicant): Gestational diabetes mellitus (GDM) complicates approximately 7% of pregnancies in the U.S. However, the epidemics of obesity and diabetes, as well as revised GDM diagnostic criteria, are dramatically increasing the prevalence of GDM, as high as 18% of pregnancies according to some estimates. This increasing prevalence is noteworthy because of the concomitant risk for adverse sequelae, not only in the peripartum period, such as increased rates of caesarean section delivery and neonatal birth injury, but also subsequent to pregnancy, including increased risk for type 2 diabetes mellitus (T2DM) for both mother and offspring. Early identification of women at increased risk for GDM would provide the opportunity for the development of targeted GDM and T2DM risk prevention strategies. Our proposal capitalizes on our expertise in emerging technologies, as well as our existing study populations, to further characterize women at increased risk for developing GDM and T2DM. Our Specific Aim 1 will examine a cohort of women followed during pregnancy for the development of GDM. Our Specific Aims 2-4 will examine the cohort of women within the Diabetes Prevention Program (DPP) with a history of GDM for the development of T2DM while examining the effects of study intervention and race on the outcome. PUBLIC HEALTH RELEVANCE: Our proposal has significant public health implications as it focuses on identifying women at increased risk for gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). We will use ground- breaking technology to identify these women so that we may best direct efforts to reduce the burden of GDM and T2DM.

描述（由申请人提供）：在美国，妊娠期糖尿病（GDM）并发症约占妊娠期糖尿病的7%。然而，肥胖和糖尿病的流行，以及修订的GDM诊断标准，显著增加了妊娠期糖尿病的患病率，据估计高达妊娠期糖尿病的18%。这种增加的患病率值得注意，因为伴随不良后遗症的风险，不仅在围产期，如剖腹产和新生儿损伤的发生率增加，而且在怀孕后，包括母亲和后代患2型糖尿病（T2DM）的风险增加。早期识别GDM风险增加的女性将为制定有针对性的GDM和T2DM风险预防策略提供机会。我们的建议利用我们在新兴技术方面的专业知识，以及我们现有的研究人群，进一步表征患GDM和T2DM风险增加的女性。我们的具体目标1将检查妊娠期间随访的一组妇女是否发生GDM。我们的具体目标2-4将检查糖尿病预防计划（DPP）中有GDM病史的女性发展为T2DM的队列，同时检查研究干预和种族对结果的影响。