CSHL Eukaryotic DNA Replication Conference

描述(申请人提供)：2013真核DNA复制和基因组维护会议本次会议将是关于真核DNA复制和基因组维护的第14次两年一度的会议，自1987年9月以来，每隔一年在冷泉港举行一次非常成功的会议。这是唯一一次定期召开的专门讨论真核DNA复制的会议。由于这一焦点，会议在我们对真核DNA复制过程以及它如何整合到细胞分裂周期的理解方面发挥了重要作用。今年的会议将致力于与染色体复制、结构和功能相关的基础研究课题，并将包括细胞周期和生长控制、基因组扩增以及复制设备对DNA损伤的反应等重要生物学研究领域。从2007年的会议开始，我们更加强调了DNA复制在DNA损伤和复制应激反应中的核心作用，以及细胞使用的将DNA复制对基因组完整性的威胁降至最低的策略。DNA复制和DNA损伤反应领域的快速融合使这次会议成为一次及时的会议。会议的形式将确保面对面地交流和讨论最近的成果，这将加强进展和协作。强烈鼓励青年研究人员以及少数族裔和女性科学家参与。2013年会议将包括一系列不同的主题、系统和方法，包括研究：(1)在酵母、果蝇、非洲爪哇和哺乳动物细胞等各种生物中的染色体复制和基因扩增；(2)病毒染色体的复制，包括SV40、多瘤病毒、巨细胞病毒、疱疹病毒、乳头瘤病毒和EB病毒；(3)细胞周期中DNA复制的控制；(4)控制复制的染色体元件的结构和功能，包括复制和端粒的起源；(5)DNA复制与细胞周期、染色质修饰、发育和癌症之间的联系；(6)控制基因组完整性的机制，包括DNA复制检查点和复制后DNA修复；(7)新方法，包括基因组学、系统生物学和单分子研究。由于脱氧核糖核酸复制对细胞分裂至关重要，生长失控是肿瘤的标志，S期是化疗和放射治疗的主要靶点，而脱氧核糖核酸复制错误会导致基因组不稳定，因此这次会议对癌症研究以及最终改进治疗方法的相关性怎么强调都不为过。DNA的复制是所有(真核)生命的基本过程。这次会议将重点了解这一过程发生的机制，以及DNA复制如何有助于基因组稳定和维持细胞的表观遗传状态。这次会议的学术价值包括让处于科学生涯各个阶段的主要研究人员有机会分享和讨论他们的最新成果和概念。口头和海报会议中的非正式同行审查在提供快速反馈方面非常宝贵，这将卓有成效地指导和加速未来的研究。这次会议 也为学习和建立合作提供了充足的机会--没有计划举行平行会议，因此所有与会者都分享了共同的经历，而与世隔绝的场地最大限度地增加了进行富有成效的科学交流的可能性。大型会议通常会在各自的领域产生重大影响。这次会议具有特别广泛影响的独特方面是年轻科学家的积极参与，他们将特别受益于提出他们的最新想法的机会。会议档案(可通过互联网访问的主要系列视频档案)允许与会者与无法出席的同事分享会议的各个方面，同时保护提交报告的作者提出未发表研究的权利。

DESCRIPTION (provided by applicant):: 2013 CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE This conference will be the 14th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every second year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. Starting with the 2007 meeting, we placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response and the strategies used by cells to minimize the threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results will be communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators and minority and women scientists is strongly encouraged. The 2013 meeting will include a diverse array of topics, systems, and approaches including studies of: (1) chromosomal replication and gene amplification in organisms as diverse as yeast, Drosophila, Xenopus and mammalian cells; (2) the replication of viral chromosomes, including SV40, polyomavirus, cytomegalovirus, herpesvirus, papillomaviruses, and Epstein-Barr virus; (3) control of DNA replication in the cell cycle; (4) structure and function of the chromosomal elements controlling replication including origins of replication and telomeres; (5) connections between DNA replication and the cell cycle, chromatin modifications, development, and cancer; (6) mechanisms that control genomic integrity including DNA replication checkpoints and post-replication DNA repair; (7) novel approaches including genomics, systems biology, and single molecule studies. Since DNA replication is crucial to cell division, uncontrolled growth is a hallmark of tumors, S phase is a major target for chemo- and radiotherapy and errors in DNA replication lead to genomic instability, the relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and building collaborations - no parallel sessions are planned and so all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large conferences generally can have significant impact in their field. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.