Innovative Multidisciplinary Education: The Statistical Genetics of Addiction

创新的多学科教育：成瘾的统计遗传学

基本信息

批准号：
8452727
负责人：
Shine Chang
金额：
$ 28.23万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8452727
关键词：
Academy Addictive Behavior Adopted Advisory Committees Alcohol abuse Alcoholism Analgesics Appointment Area Authorship Behavioral Behavioral Sciences Biological Biometry Chalk Child Clinical Collaborations Commit Complement Complex Computer Simulation Data Databases Development Discipline Division of Cancer Prevention Doctor of Philosophy Education Education Projects Educational Activities Educational Curriculum Educational process of instructing Environment Epidemiology Equipment and supply inventories Evaluation Faculty Failure Fostering Funding Genes Genetic Genetic Predisposition to Disease Genetic Programming Genetic Risk Genetic Variation Hawks Head Health Health Sciences Health Services Research Individual Institutes Institution Institutional Review Boards International Investigation Journals Knowledge Leadership Letters Malignant neoplasm of brain Malignant neoplasm of lung Mediation Medicine Mentors Mentorship Meta-Analysis Methodology Methods Modeling Monitor National Institute of Drug Abuse Nature Nicotine Nicotine Dependence Opiate Addiction Opioid Outcome Paper Participant Pathway interactions Pattern Play Policies Population Sciences Positioning Attribute Postdoctoral Fellow Prevention Research Procedures Process Program Evaluation Progress Reports Public Health Schools Qualifying Recruitment Activity Research Research Activity Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Training Resources Rice Role Schools Science Science of genetics Scientist Series Simulate Statistical Methods Students Testing Texas Time Tobacco use Training Training Programs Universities University of Texas M D Anderson Cancer Center Update Washington Work addiction base behavioral health biobehavior cancer prevention college cost doctoral student experience gene environment interaction genetic epidemiology genetic risk factor genome wide association study graduate student health disparity high risk high throughput technology improved innovation interest lectures medical schools member multidisciplinary novel operation pre-doctoral prescription opioid prevent programs psychosocial success tool

项目摘要

DESCRIPTION (provided by applicant): The proposed research education program, has three objectives: 1) to provide innovative education in statistical genetics methods for addictive behaviors to graduate students and postdoctoral fellows; 2) to involve and mentor them in the development and application of new statistical methods and computational models relevant to analyze the vast and ever increasing genetic data being generated from emerging high throughput technologies; and 3) to apply such methods to critical questions in the genetics of addiction. We have focused on two overarching and inter-related addictive disorders with which our Program leaders and mentors have significant expertise: nicotine and opiate dependence. We offer a rich data infrastructure of ongoing and completed studies pertinent to the genetics of select addictive behaviors. We propose to develop curriculum-based methods that provide new knowledge and opportunities for graduate students and postdoctoral fellows to work with faculty mentors on research projects focusing on statistical genetics and computational modeling approaches to nicotine and prescription opioid addiction. We will select two pre-doctoral students and one postdoctoral fellow in the first year. Each subsequent year, we will increase the number of participants and at the end of 5 years we will have appointed 5 predoctoral students and 5 postdoctoral fellows each for a maximum of five years. Mentors have been identified from the faculty of collaborating institutions where participants will have their primary appointments including The University of Texas M. D. Anderson Cancer Center, UT Health Science Center and School of Public Health, Baylor College of Medicine, and Rice University. Additional mentors who are leaders in addiction and statistical genetics also serve on the Program Advisory Committee from the National Institutes of Alcohol Abuse and Alcoholism, Rockefeller University, and Texas A&M. These mentors have agreed to join the Program for their expertise and experience in addiction research, statistical genetics and computational models, behavioral science, and genetic epidemiology. The significance of this research education program then is multi-fold. In addition to teaching students to become statistical genetic leaders with a focus in addiction research, it is anticipated that robust new statistical methodologies will be tested and validated and finally that novel genetic targets will be identified. The identification of novel genetic risk factors and their interaction with the environment can contribute to understanding the genetic etiology of nicotine and opiate addiction and help to identify individuals at highest risk as well as to develop targeted therapies on the basis of their personal exposure patterns and their genetic risk profiles. In summary, changing patterns of tobacco use and growing illicit use of prescription pain killers, particularly by children, make the significance of educating these new scientists and launching them in research paramount.

描述（由申请人提供）：拟议的研究教育计划有三个目标：1）为研究生和博士后研究员提供统计遗传学方法的创新教育； 2）让他们参与并指导他们的开发和应用新的统计方法和计算模型，以分析新兴高吞吐量技术产生的广泛而又不断增加的遗传数据； 3）将这种方法应用于成瘾遗传学中的关键问题。我们专注于两个总体和相互关联的成瘾性疾病，我们的计划领导者和导师具有重要的专业知识：尼古丁和阿片类药物的依赖。我们为正在进行的研究和完成的研究提供了丰富的数据基础架构，这些研究与某些成瘾行为的遗传学有关。我们建议开发基于课程的方法，为研究生和博士后研究员提供新的知识和机会，以与教师导师合作研究研究项目，重点介绍统计遗传学和计算建模方法，以实现尼古丁和处方阿片类药物成瘾。第一年，我们将选择两个博士后学生和一名博士后研究员。每年的每一年，我们都会增加参与者的数量，在5年结束时，我们将任命5名学生和5名博士后研究员，最多五年。从合作机构的学院确定了导师，参与者将进行主要任命，包括德克萨斯大学M. D.安德森癌症中心，UT健康科学中心和公共卫生学院，贝勒医学院和莱斯大学。作为成瘾和统计遗传学领导者的其他导师还在国立酒精滥用和酒精中毒，洛克菲勒大学和德克萨斯州A＆M的计划咨询委员会任职。这些导师已同意加入该计划，以在成瘾研究，统计遗传学和计算模型，行为科学和遗传流行病学方面的专业知识和经验。然后，该研究教育计划的重要性是多重的。除了教学学生成为成瘾研究重点的统计遗传领导者之外，还可以测试和验证强大的新统计方法论，最后将确定新的遗传靶标。鉴定新的遗传危险因素及其与环境的相互作用可以有助于理解尼古丁的遗传病因和阿片类成瘾，并帮助识别具有最高风险的个体，并根据其个人暴露模式及其遗传风险概况开发目标疗法。总而言之，烟草使用和日益增长地使用处方止痛药的非法使用模式，尤其是儿童，具有教育这些新科学家并在研究中推出它们的重要性。