KY IDeA Networks of Biomedical Research Excellence

KY IDeA 生物医学研究卓越网络

• 批准号: 8484409
• 负责人: NIGEL G.F. COOPER
• 金额: $ 284.98万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484409
• 关键词: Bioinformatics; Biomedical Research; Clinical Research; Communities; Development; Educational Curriculum; Educational process of instructing; Educational workshop; Electronic Health Record; Faculty; Funding; Future; Genomics; Goals; Grant; Growth and Development function; Health; Health Sciences; Incentives; Institution; Kentucky; Lead; Mentors; Mission; Neurosciences; Patients; Postdoctoral Fellow; Proteomics; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Rural; Training; Training Programs; Universities; Writing; base; career; career development; college; community based participatory research; design; graduate student; health care service organization; improved; innovation; interest; next generation; programs; prospective; skills; undergraduate student; web-accessible

The Kentucky INBRE serves a statewide mission to build infrastructure and capacity for biomedical and health-related research and training as well as for bioinformatics. In this application, the University of Louisville is partnered with the University of Kentucky, Berea College, Eastern Kentucky University, Morehead State University, Northern Kentucky University and Western Kentucky University to continue the development of our collaborative network. The goals of our network are to build competitive research and training programs in the biomedical and health sciences, particularly in the fields of genomics and neuroscience, as well as to build competitive bioinformatics programs. These efforts will lead to improved prospects for career development for our undergraduate and graduate students, postdoctoral fellows, and young faculty investigators. In this application, we propose mechanisms to sustain as well as grow the competitive research component of this program as this aspect is viewed as critical to the establishment of our training and career development activities. This will include support for teaching-postdoctoral fellows and research associates for existing investigators, program support for new research investigators, and for the initiation of new developmental research projects. For bioinformatics, we aim to support projects with the potential for development as competitive independent, and/or collaborative, proposals. To enhance the career development aspects for faculty, postdoctoral fellows and prospective researchers in our program we will develop a mentoring team of proven investigators to provide workshops on grant writing skills and disseminate materials related to best practices. We intend to continue partial funding of our centralized microarray facility which is essential to the development of genomics-based research projects at this and other institutions, and we will continue to develop initiatives in aid of our growing proteomics research base. We propose to establish a new, community-based participatory research core. As a first step, this core will establish web-accessible de-identified electronic health records for health care organizations in rural Kentucky. Health information gained from this activity will be used to inform the future development of our undergraduate and graduate curriculum content and our biomedical research goals. The infrastructure will also be used to enable the patient community to indicate their interest in participating in relevant clinical research trials. In summary, our strategy is designed to strengthen and build our infrastructure and capacity and to build an innovative next generation network.

肯塔基州INBRE服务于全州范围内的使命，为生物医学和健康相关的研究和培训以及生物信息学建立基础设施和能力。在此应用程序中，路易斯维尔大学与肯塔基州大学，伯里亚学院，东肯塔基州大学，莫尔黑德州立大学，北方肯塔基州大学和西肯塔基州大学合作，继续我们的合作网络的发展。我们网络的目标是在生物医学和健康科学领域建立有竞争力的研究和培训计划，特别是在基因组学和神经科学领域，以及建立有竞争力的生物信息学计划。这些努力将导致我们的本科生和研究生，博士后研究员和年轻的教师研究人员的职业发展前景改善。在这个应用程序中，我们提出的机制，以维持以及发展该计划的竞争力的研究组成部分，因为这方面被视为我们的培训和职业发展活动的建立至关重要。这将包括对现有研究人员的教学博士后研究员和研究助理的支持，对新研究人员的计划支持，以及对新发展研究项目的启动。对于生物信息学，我们的目标是支持具有发展潜力的项目，作为竞争性独立和/或合作的提案。为了提高教师，博士后研究员和未来的研究人员在我们的计划的职业发展方面，我们将开发一个经过验证的研究人员的指导团队，提供赠款写作技巧研讨会和传播有关最佳实践的材料。我们打算继续为我们的集中式微阵列设施提供部分资金，这对本机构和其他机构开发基于基因组学的研究项目至关重要，我们将继续制定计划，以帮助我们不断增长的蛋白质组学研究基地。我们建议建立一个新的、以社区为基础的参与性研究核心。作为第一步，该核心将为肯塔基州农村的医疗保健组织建立可通过网络访问的去识别电子健康记录。从这项活动中获得的健康信息将用于通知我们的本科生和研究生课程内容和我们的生物医学研究目标的未来发展。该基础设施还将用于使患者群体能够表示他们有兴趣参与相关的临床研究试验。总而言之，我们的战略旨在加强和建设我们的基础设施和能力，并建立一个创新的下一代网络。

项目成果

Dopamine modulates effort-based decision making in rats.

• DOI: 10.1037/a0014625
• 发表时间: 2009-04
• 期刊: BEHAVIORAL NEUROSCIENCE
• 影响因子: 1.9
• 作者: Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
• 通讯作者: Green, Leonard

A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT.

• DOI: 10.1038/bjc.2011.465
• 发表时间: 2012-01-03
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Bryant, J. L.;Britson, J.;Balko, J. M.;Willian, M.;Timmons, R.;Frolov, A.;Black, E. P.
• 通讯作者: Black, E. P.

A novel application of quantile regression for identification of biomarkers exemplified by equine cartilage microarray data.

分位数回归用于鉴定生物标志物的新应用，以马软骨微阵列数据为例。

• DOI: 10.1186/1471-2105-9-300
• 发表时间: 2008-07-02
• 期刊: BMC BIOINFORMATICS
• 影响因子: 3
• 作者: Huang, Liping;Zhu, Wenying;Saunders, Christopher P.;MacLeod, James N.;Zhou, Mai;Stromberg, Arnold J.;Bathke, Arne C.
• 通讯作者: Bathke, Arne C.

Quadratic regression analysis for gene discovery and pattern recognition for non-cyclic short time-course microarray experiments.

• DOI: 10.1186/1471-2105-6-106
• 发表时间: 2005-04-25
• 期刊: BMC BIOINFORMATICS
• 影响因子: 3
• 作者: Liu, H;Tarima, S;Borders, AS;Getchell, TV;Getchell, ML;Stromberg, AJ
• 通讯作者: Stromberg, AJ

Alcohol mixed with energy drinks: consumption patterns and motivations for use in U.S. college students.

• DOI: 10.3390/ijerph8083232
• 发表时间: 2011-08
• 期刊: International journal of environmental research and public health
• 作者: Marczinski CA