Neural systems for the dynamic use of memory

动态使用记忆的神经系统

• 批准号: 8423367
• 负责人: JOEL L VOSS
• 金额: $ 24.02万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8423367
• 关键词: Accounting; Affect; Aging; Aging-Related Process; Alzheimer' s Disease; Amnesia; Anxiety Disorders; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Behavioral; Brain; Brain Diseases; Brain Injuries; Brain region; California; Cognition; Cognitive; Commit; Complex; Computers; Development; Development Plans; Disease; Elderly; Electroencephalography; Elements; Environment; Event; Feedback; Functional Magnetic Resonance Imaging; Future; Goals; Human; Illinois; Impaired cognition; Impairment; Individual; Institutes; Intervention; Iowa; Knowledge; Laboratories; Learning; Lesion; Limbic System; Literature; Measures; Medicine; Memory; Memory impairment; Mentors; Methods; Mood Disorders; Nature; Neurodegenerative Disorders; Obesity; Organism; Patients; Physiological; Prefrontal Cortex; Process; Research; Research Personnel; Resources; Schizophrenia; Science; Simulate; Societies; Structure; Support System; System; Technology; Therapeutic Intervention; Training; Universities; abstracting; addiction; age effect; age related; base; behavior influence; career; career development; clinically relevant; cognitive control; cognitive neuroscience; college; combat; design; executive function; focal brain damage; meetings; memory process; neuromechanism; neuropsychological; normal aging; novel; programs; relating to nervous system; remediation; research study; virtual reality; young adult

Item 6. Project Summary/Abstract A career development plan is proposed for Dr. Joel Voss, a cognitive neuroscientist committed to a research career studying the brain substrates of memory and memory decline due to various pathological states. Dr. Neal Cohen at the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign will mentor the applicant. Dr. Cohen is an eminent scholar of the neural basis of memory and has a long record of training successful researchers, and the Beckman Institute provides a rich environment for cognitive neuroscience training. Furthermore, two renowned memory researchers will contribute to the scientific development of the applicant, including Dr. Mark D'Esposito at the University of California at Berkeley and Dr. Daniel Tranel at the University of Iowa College of Medicine. Dr. Voss' training will include developing expertise with multi-methods approaches to identifying the brain substrates of cognition and behavior. Training will involve noninvasive methods for measuring brain activity as well as the study of cognitive impairments in patients with focal brain damage and the effects of temporary disruption of neural processing in healthy individuals. Training will also involve studying the effects of aging on memory and using computer-simulated environments to study cognition in realistic circumstances. The proposed research program aims to discover how coordinated neural systems optimize learning and memory by strategically allocating resources in order to meet the demands of a particular learning situation. This process depends upon the confluence of executive function, attention, and memory, and is disrupted by pathological events that target the brain substrates of these three cognitive domains, such as Alzheimer's disease, Schizophrenia, ADD/ADHD, and autism. The research also seeks to develop optimal strategies that can be used by older individuals to combat the pervasive challenge of age-related memory decline, which affects almost every individual as a result of normal aging. The proposed research has transparent clinical relevance with regard to remediation of the memory deficits of older individuals and broad relevance with regard to understanding the mechanisms of pathological effects on executive function, attention, and memory.

项目6。项目总结/文摘