Midcareer Investigator Award in Patient-Oriented NeuroAIDS Research

以患者为导向的神经艾滋病研究中职业生涯调查员奖

• 批准号: 8466639
• 负责人: Scott L Letendre
• 金额: $ 18.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8466639
• 关键词: AIDS neuropathy; Address; Affect; Anti-Retroviral Agents; Appointment; Area; Award; Biological Assay; Biological Markers; Brain; Chronic Disease; Clinical Research; Clinical Research Curriculum Award; Clinical Trials; Collaborations; Continuing Education; Cytomegalovirus; Data; Development; Diagnosis; Diagnostic; Disease; Doctor of Medicine; Drug Interactions; Drug Kinetics; Education; Education Projects; Educational process of instructing; Equipment; Event; Faculty; Fellowship; Fibroblast Growth Factor; Funding; Goals; Grant; HIV; Hepatitis C virus; Individual; Infection; Influentials; Institutional National Research Service Award; International; Junior Physician; K-Series Research Career Programs; Laboratories; Lead; Leadership; Life; Light; Measurement; Measures; Medical Students; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; National Institute of Mental Health; Nebraska; Nervous system structure; Neurocognitive; Neurologic; Outcome; Performance; Pharmaceutical Preparations; Pharmacology; Plasma; Plasmodium; Population; Postdoctoral Fellow; Prognostic Marker; Proteins; Regimen; Research; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Scientist; Secure; Time; Toxoplasma; Training; Translational Research; Wages; Work; addiction; antimicrobial; antiretroviral therapy; career; cost; design; drug distribution; graduate student; instrument; interdisciplinary approach; interest; longitudinal analysis; nervous system disorder; neurofilament; outcome forecast; pathogen; patient oriented; patient oriented research; professor; public health relevance; screening; skills; success; young adult

DESCRIPTION (provided by applicant): Scott Letendre, M.D. is an Associate Professor of Medicine at UCSD and former K23 Career Development Award recipient. In the past decade, Dr. Letendre has led or collaborated on many publicly and privately funded translational research projects. His influential work has focused on the risk factors and treatment of HIV-associated neurocognitive disorder (HAND) in the US and international settings. During this period, he has also mentored more than 30 trainees in patient-oriented research, including graduate and medical students, post-doctoral researchers, and junior faculty. In the proposed K24 mid-career investigator award, Dr. Letendre will expand his mentoring of junior investigators and will focus his mentoring and his own research on three main objectives. Antiretroviral treatment of the nervous system: Dr. Letendre will mentor trainees on design and performance of HAND clinical trials and CSF pharmacology projects, particularly focusing on longitudinal projects that measure all drugs in an antiretroviral regimen to better understand how drug interactions and time influence virologic and neurocognitive outcomes. Biomarker correlates of disease and treatment: Dr. Letendre will mentor trainees on measurement and analysis of biomarker data with the goal of developing a clinically useful panel for screening, diagnosis, and prognosis of HAND. This work will be supported by new equipment purchased with funds from a recent S10 Shared Instrument Grant. Coinfections in HIV-infected individuals: Dr. Letendre will work with trainees on projects that evaluate the impact on the nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr. Letendre's existing work in international settings. Dr. Letendre will mentor trainees using a multidisciplinary approach that includes regular direct engagement, participation in R25, T32, and K30 programs at UCSD, active participation in existing research projects, support for new research projects, and networking with other investigators. Dr. Letendre will also obtain training in mentoring and analysis of longitudinal data. In summary, this K24 award will secure protected time for Dr. Letendre to mentor trainees in neuroAIDS methods, including the responsible conduct of patient- oriented research. Dr. Letendre will coordinate his efforts with other UCSD resources, including the R25- funded "International Research Fellowship in NeuroAIDS", the T32-funded "Training in Research on Addictions in Interdisciplinary NeuroAIDS", and the CTSA-funded "Clinical and Translational Research Institute".

描述（由申请人提供）：医学博士Scott Letendre是UCSD医学副教授和前K23职业发展奖获得者。在过去的十年中，Letendre博士领导或合作了许多公共和私人资助的翻译研究项目。他的有影响力的工作集中在美国和国际环境中与艾滋病毒相关的神经认知障碍（手）的治疗。在此期间，他还指导了30多名以患者为导向的研究，包括研究生和医学生，博士后研究人员和初级教师。在拟议的K24中级调查员奖中，Letendre博士将扩大对初级调查人员的指导，并将将他的指导和自己的研究集中在三个主要目标上。神经系统的抗逆转录病毒治疗：Letendre博士将指导受训者有关手动临床试验和CSF药理学项目的设计和性能，特别是专注于纵向项目，这些纵向项目测量了抗逆转录病毒方案中的所有药物，以更好地了解药物相互作用和时间影响病毒学性和神经认知能力。生物标志物的疾病和治疗相关性：Letendre博士将指导学员对生物标志物数据进行测量和分析，以开发一个临床上有用的小组，以筛查，诊断和预后。这项工作将由最近的S10共享工具赠款购买的新设备提供支持。 HIV感染者的共同感染：Letendre博士将与受训者合作，以评估对病原体（例如疟原虫，巨细胞病毒，毒素，毒质量和肝炎）病原体的潜在或微小症状感染的影响。这项工作将特别关注Letendre博士在国际环境中的现有工作。 Letendre博士将使用多学科的学员指导受训者，其中包括定期直接参与，参与UCSD的R25，T32和K30计划，积极参与现有研究项目，对新研究项目的支持以及与其他研究人员进行网络。 Letendre博士还将获得纵向数据指导和分析的培训。总而言之，该K24奖将为Letendre博士提供受保护的时间，以指导受训者的神经辅助方法，包括负责患者的研究。 Letendre博士将与其他UCSD资源进行协调，包括R25资助的“国际神经辅助研究奖学金”，T32资助的“跨学科神经辅助研究成瘾研究培训”以及CTSA资助的“临床和转化研究所”。