Midcareer Investigator Award in Patient-Oriented NeuroAIDS Research

以患者为导向的神经艾滋病研究中职业生涯调查员奖

• 批准号: 8594262
• 负责人: Scott L Letendre
• 金额: $ 18.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8594262
• 关键词: AIDS neuropathy; Address; Affect; Anti-Retroviral Agents; Appointment; Area; Award; Biological Assay; Biological Markers; Brain; Chronic Disease; Clinical Research; Clinical Research Curriculum Award; Clinical Trials; Collaborations; Continuing Education; Cytomegalovirus; Data; Development; Diagnosis; Diagnostic; Disease; Doctor of Medicine; Drug Interactions; Drug Kinetics; Education; Education Projects; Educational process of instructing; Equipment; Event; Faculty; Fellowship; Fibroblast Growth Factor; Funding; Goals; Grant; HIV; Hepatitis C virus; Individual; Infection; Influentials; Institutional National Research Service Award; International; Junior Physician; K-Series Research Career Programs; Laboratories; Lead; Leadership; Life; Light; Measurement; Measures; Medical Students; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; National Institute of Mental Health; Nebraska; Nervous system structure; Neurocognitive; Neurologic; Outcome; Performance; Pharmaceutical Preparations; Pharmacology; Plasma; Plasmodium; Population; Postdoctoral Fellow; Prognostic Marker; Proteins; Regimen; Research; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Scientist; Secure; Time; Toxoplasma; Training; Translational Research; Wages; Work; addiction; antimicrobial; antiretroviral therapy; career; cost; design; drug distribution; graduate student; instrument; interdisciplinary approach; interest; longitudinal analysis; nervous system disorder; neurofilament; outcome forecast; pathogen; patient oriented; patient oriented research; professor; public health relevance; screening; skills; success; young adult

DESCRIPTION (provided by applicant): Scott Letendre, M.D. is an Associate Professor of Medicine at UCSD and former K23 Career Development Award recipient. In the past decade, Dr. Letendre has led or collaborated on many publicly and privately funded translational research projects. His influential work has focused on the risk factors and treatment of HIV-associated neurocognitive disorder (HAND) in the US and international settings. During this period, he has also mentored more than 30 trainees in patient-oriented research, including graduate and medical students, post-doctoral researchers, and junior faculty. In the proposed K24 mid-career investigator award, Dr. Letendre will expand his mentoring of junior investigators and will focus his mentoring and his own research on three main objectives. Antiretroviral treatment of the nervous system: Dr. Letendre will mentor trainees on design and performance of HAND clinical trials and CSF pharmacology projects, particularly focusing on longitudinal projects that measure all drugs in an antiretroviral regimen to better understand how drug interactions and time influence virologic and neurocognitive outcomes. Biomarker correlates of disease and treatment: Dr. Letendre will mentor trainees on measurement and analysis of biomarker data with the goal of developing a clinically useful panel for screening, diagnosis, and prognosis of HAND. This work will be supported by new equipment purchased with funds from a recent S10 Shared Instrument Grant. Coinfections in HIV-infected individuals: Dr. Letendre will work with trainees on projects that evaluate the impact on the nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr. Letendre's existing work in international settings. Dr. Letendre will mentor trainees using a multidisciplinary approach that includes regular direct engagement, participation in R25, T32, and K30 programs at UCSD, active participation in existing research projects, support for new research projects, and networking with other investigators. Dr. Letendre will also obtain training in mentoring and analysis of longitudinal data. In summary, this K24 award will secure protected time for Dr. Letendre to mentor trainees in neuroAIDS methods, including the responsible conduct of patient- oriented research. Dr. Letendre will coordinate his efforts with other UCSD resources, including the R25- funded "International Research Fellowship in NeuroAIDS", the T32-funded "Training in Research on Addictions in Interdisciplinary NeuroAIDS", and the CTSA-funded "Clinical and Translational Research Institute".

描述(由申请人提供)：Scott Letendre，医学博士，加州大学圣迭戈分校医学副教授，前K23职业发展奖获得者。在过去的十年里，勒滕德博士领导或合作了许多由公共和私人资助的翻译研究项目。他有影响力的工作集中在美国和国际环境中艾滋病毒相关神经认知障碍(HAND)的风险因素和治疗上。在此期间，他还指导了30多名以患者为中心的研究实习生，包括研究生和医学生、博士后研究人员和初级教职员工。在拟议的K24职业生涯中期调查员奖中，勒滕德尔博士将扩大他对初级调查人员的指导，并将他的指导和自己的研究集中在三个主要目标上。神经系统的抗逆转录病毒治疗：Letendre博士将指导受训人员手部临床试验和脑脊液药理学项目的设计和执行，特别关注纵向项目，这些项目衡量抗逆转录病毒方案中的所有药物，以更好地了解药物相互作用和时间如何影响病毒学和神经认知结果。生物标记物与疾病和治疗的相关性：Letendre博士将指导受训人员对生物标记物数据的测量和分析，目标是开发一个临床有用的小组，用于手部的筛查、诊断和预后。这项工作将得到用最近的S10共享仪器赠款资金购买的新设备的支持。HIV感染者的混合感染：Letendre博士将与受训人员一起开展项目，评估疟疾、巨细胞病毒、弓形虫和丙型肝炎病毒等病原体的潜伏感染或症状轻微感染对神经系统的影响。这项工作将特别侧重于勒滕德博士在国际环境中的现有工作。Letendre博士将使用多学科方法指导学员，包括定期直接参与，参与加州大学圣迭戈分校的R25、T32和K30项目，积极参与现有研究项目，支持新的研究项目，以及与其他研究人员建立联系。勒滕德博士还将接受指导和纵向数据分析方面的培训。总而言之，这项K24奖项将确保勒滕德博士有足够的时间指导受训人员神经艾滋病的治疗方法，包括负责任地进行以患者为中心的研究。Letendre博士将与UCSD的其他资源协调工作，这些资源包括R25资助的“神经艾滋病国际研究奖学金”、T32资助的“跨学科神经艾滋病成瘾研究培训”以及CTSA资助的“临床和翻译研究所”。