Induction of antigen-specific tolerance through inhibition of RelB function in dendritic cells

通过抑制树突状细胞中的 RelB 功能诱导抗原特异性耐受

• 批准号: nhmrc : 210237
• 负责人: Dr Brendan O'Sullivan
• 金额: $ 28.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/induction-antigen-specific-dendritic-cells/82664
• 关键词: Induction; antigen; specific; tolerance; through

This proposal builds on preliminary data showing the possibility that responses of the immune system to antigens can be suppressed by modifying cells known as dendritic cells using an inhibitory drug. The drug appears to be able to control the ability of dendritic cells to educate the immune system about antigens. When antigens presented continuously are harmful to the immune system, they produce diseases such as rheumatoid arthritis and allergies. The experiments to be undertaken specifically look at means to prevent and reverse diseases like rheumatoid arthritis through the use of dendritic cells.

这一建议建立在初步数据的基础上，该数据表明，免疫系统对抗原的反应可以通过使用抑制药物修改被称为树突状细胞的细胞来抑制。这种药物似乎能够控制树突状细胞对免疫系统进行抗原教育的能力。当持续呈现的抗原对免疫系统有害时，它们会产生类风湿性关节炎和过敏等疾病。将进行的实验专门着眼于通过使用树突状细胞来预防和逆转类风湿性关节炎等疾病的方法。