Visual Science Training Grant

描述（由申请人提供）：本申请拟在耶鲁大学医学院提供视觉科学研究方面的综合培训，特别强调视觉神经科学。该计划的目标是培养视觉神经科学的跨学科方法，将与分子遗传学和临床医学相结合，研究眼睛和中央视觉系统的发育、组织、功能和功能障碍。来自5个基础和临床科室的12名教师参与了这个多学科项目。这些教师在耶鲁大学的视觉研究社区中领导着充满活力的视觉研究项目，这个社区经历了一个令人兴奋的复兴和扩张阶段，吸引了越来越多的优秀研究生和博士后。拟议的培训计划既有深度又有广度。这种深度源于它对眼睛和视觉系统的神经生物学的实质性关注。该计划的广度源于方法的多样性，跨越分子，发育，系统，认知和理论神经科学，以及这些研究中使用的实验模型的范围，跨越斑马鱼，啮齿动物和灵长类动物。教师的兴趣范围从视网膜发育和退化，视网膜生理和电路，视觉皮质功能和视觉行为。方法包括克隆；细胞培养;免疫细胞化学;原位杂交；基因转染和转基因技术，电子和双光子显微镜；膜片钳和多电极记录；视黄电、钙等形式的光学成像；生物化学和分子分析；精神药理学;啮齿动物、猴子和人类的行为；行为动物的体内细胞外记录；以及fMRI和PET成像。招收博士生前、博士后各2名。执行委员会将根据学员在研究方面的卓越潜力和领导能力，从不同的生物科学背景中挑选学员。导师是获得NEI和其他NIH研究所资助或NEI相关研究重点的博士和医学博士。培训包括课程作业、密集的研究学徒制、结构化的研讨会计划、实验室和部门的研究进展报告，以及负责任的研究行为指导。小灵通398/2590 （Rev. 06/09）页延续格式页

DESCRIPTION (provided by applicant): This application proposes to provide integrative training in visual science research at Yale University School of Medicine, with a special emphasis on visual neuroscience. The goal of this program is to foster interdisciplinary approaches to visual neuroscience that will interface with molecular genetics and clinical medicine with respect to development, organization, function and dysfunction of the eye and the central visual system. Twelve faculty preceptors from five basic and clinical departments participate in this multidisciplinary program. These faculty members lead vibrant vision research programs in a vision research community at Yale that has undergone an exciting phase of revitalization and expansion, and that has attracted an increasing number of outstanding graduate students and postdoctoral fellows. The proposed training program offers both depth and breadth. The depth derives from its substantive focus on the neurobiology of the eye and the visual system. The breadth of the program derives from the diversity of approaches, spanning molecular, developmental, systems, cognitive and theoretical neuroscience, as well as from the range of experimental models used in these studies, spanning zebrafish, rodents, and primates. Faculty interests range from retinal development and degeneration, retinal physiology and circuits to visual cortical function and visual behavior. Methodologies include cloning; cell culture; immunocytochemistry; in situ hybridization; gene transfection and transgenic technology, electron and two photon microscopy; patch-clamp and multielectrode recording; electroretinograph, calcium and other forms of optical imaging; biochemistry and molecular analyses; psycho- pharmacology; rodent, monkey and human behavior; in vivo extracellular recording in behaving animals; and fMRI and PET imaging in human subjects. Two predoctoral and two postdoctoral positions are requested. Trainees will be selected from a variety of backgrounds in biological sciences on the basis of their potential for excellence and leadership in research by an Executive Committee. Mentors are Ph.D.s and M.D.s. with NEI and other NIH institute grants or NEI related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, laboratory and departmental presentations of research progress, and instructions on responsible research conduct. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page PUBLIC HEALTH RELEVANCE: The proposed program supports predoctoral and postdoctoral training in vision research in Yale Medical School, with an emphasis on visual neuroscience. The long term goal of this proposal is to foster career development of basic, translational and clinical vision research scientists. The program draws both from the tremendous research strengths of an expanding vision research community at Yale and from an excellent and diverse pool of trainee candidates. Trainees will participate in a rigorous curriculum of training that includes coursework, laboratory research, seminars, presentations, and teaching. The outcome of the training program will directly impact our understanding of the visual system and the treatment of devastating eye diseases and visual system disorders.