Visual Science Training Grant

视觉科学培训补助金

• 批准号: 10250449
• 负责人: Z JIMMY ZHOU
• 金额: $ 15.29万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250449
• 关键词: Grant; Training; vision science

Program Director/Principal Investigator (Last, First, Middle): Zhou, Z. Jimmy Abstract This application proposes to continue an integrative training program in visual science research at Yale University School of Medicine, with a special emphasis on visual neuroscience. The goal of this program is to foster interdisciplinary approaches to visual neuroscience that will interface with molecular genetics and clinical medicine in the areas of development, organization, function, degeneration, and regeneration in the eye and the central visual system. Fourteen faculty preceptors from six basic and clinical departments participate in this multidisciplinary program. These faculty members lead vibrant vision research programs in a vision research community at Yale that has undergone an exciting phase of revitalization and expansion, and that has attracted an increasing number of outstanding graduate students and postdoctoral fellows. The proposed training program offers both depth and breadth. The depth derives from its substantive focus on the neuroscience of the eye and the visual system. The breadth of the program derives from the diversity of approaches, spanning molecular, developmental, systems, cognitive and theoretical neuroscience, as well as from the range of experimental models used in these studies, spanning drosophila, zebrafish, rodents, and primates. Faculty interests range from retinal development and degeneration, retinal physiology and circuits to visual cortical function and visual behavior. Methodologies include cloning; cell culture; immunocytochemistry; in situ hybridization; gene transfection and transgenic technology, electron and two photon microscopy; optogenetics, patch-clamp and multielectrode recording; electroretinograph, optical imaging; biochemistry and molecular analyses; psycho-pharmacology; rodent, monkey and human behavior; in vivo extracellular recording in behaving animals; and fMRI and PET imaging in human subjects. Two predoctoral and two postdoctoral positions are requested. Trainees will be selected from a variety of backgrounds in biological sciences on the basis of their potential for excellence and leadership in research by an Executive Committee. Mentors are Ph.D.s and M.D.s. with NEI and other NIH institute grants or NEI related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, laboratory and departmental presentations of research progress, and instructions on responsible research conduct. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目负责人/主要研究者（最后，第一，中间）：Zhou，Z。吉米 摘要 本申请建议继续在耶鲁大学视觉科学研究的综合培训计划 大学医学院，特别强调视觉神经科学。该计划的目标是 促进视觉神经科学的跨学科方法，将与分子遗传学和临床 眼的发育、组织、功能、退化和再生领域的医学， 中央视觉系统。来自六个基础和临床部门的十四名教师导师参加了 这个多学科的计划。这些教师领导充满活力的视觉研究计划的愿景 耶鲁大学的研究社区经历了一个令人兴奋的振兴和扩张阶段， 吸引了越来越多的优秀研究生和博士后。拟议 培训计划既有深度又有广度。其深度源于其实质性的重点， 眼睛和视觉系统的神经科学。该计划的广度源于多样性， 方法，跨越分子，发展，系统，认知和理论神经科学，以及 从这些研究中使用的实验模型的范围来看，跨越果蝇、斑马鱼、啮齿动物， 灵长类动物教师的兴趣范围从视网膜发育和变性，视网膜生理学和电路， 视觉皮层功能和视觉行为。方法学包括克隆、细胞培养、免疫细胞化学; 原位杂交、基因转染和转基因技术、电子和双光子显微镜; 光遗传学、膜片钳和多电极记录;视网膜电图、光学成像;生物化学和 分子分析;心理药理学;啮齿动物、猴和人类行为;体内细胞外 在行为动物中记录;以及在人类受试者中进行fMRI和PET成像。 两个博士前和两个博士后职位要求。学员将从各种各样的 生物科学背景的基础上，他们的潜力卓越和领导研究， 执行委员会。导师都是博士和医学博士。与NEI和其他NIH研究所赠款或NEI相关 研究焦点。培训包括课程作业，密集的研究学徒，结构化的研讨会计划， 研究进展的实验室和部门介绍，以及关于负责任研究的说明 行为。 PHS 398/2590（Rev.06/09）