Visual Science Training Grant

项目主任/首席调查员(最后、第一、中间)：周，Z.吉米 摘要 这份申请书建议继续耶鲁大学视觉科学研究的综合培训计划 大学医学院，特别强调视觉神经科学。这项计划的目标是 培养与分子遗传学和临床相结合的视觉神经科学的跨学科方法 眼和眼的发育、组织、功能、退化和再生领域的医学 中央视觉系统。来自6个基础和临床科室的14名教员参加了 这个多学科项目。这些教职员工在愿景中领导充满活力的视觉研究计划 耶鲁大学的研究界经历了令人兴奋的振兴和扩张阶段， 吸引了越来越多的优秀研究生和博士后研究员。建议数 培训计划既有深度，也有广度。这一深度源于其对 眼睛和视觉系统的神经科学。节目的广度来自于节目的多样性 方法，跨越分子、发育、系统、认知和理论神经科学，以及 从这些研究中使用的一系列实验模型中，跨越果蝇、斑马鱼、啮齿动物和 灵长类动物。教职员工的兴趣范围从视网膜发育和退化、视网膜生理学和视网膜电路到 视觉皮质功能和视觉行为。方法包括克隆；细胞培养；免疫细胞化学； 原位杂交；基因导入和转基因技术；电子显微镜和双光子显微镜； 光遗传学，膜片钳和多电极记录；视网膜电图仪，光学成像；生物化学和 分子分析；心理药理学；啮齿动物、猴子和人类行为；活体细胞外 在行为动物中进行记录；在人类受试者中进行功能磁共振成像和PET成像。 申请两个博士后和两个博士后职位。受训者将从各种不同的 生物科学的背景，基于他们在研究方面的卓越潜力和领先地位 一个执行委员会。导师是博士和医学博士。与NEI和其他NIH研究所拨款或NEI相关 研究重点。培训包括课程作业，密集的研究学徒，有组织的研讨会计划， 实验室和部门对研究进展的介绍，以及关于负责任研究的指示 品行。 PHS 398/2590(06/09版)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Zhou, Z. Jimmy Abstract This application proposes to continue an integrative training program in visual science research at Yale University School of Medicine, with a special emphasis on visual neuroscience. The goal of this program is to foster interdisciplinary approaches to visual neuroscience that will interface with molecular genetics and clinical medicine in the areas of development, organization, function, degeneration, and regeneration in the eye and the central visual system. Fourteen faculty preceptors from six basic and clinical departments participate in this multidisciplinary program. These faculty members lead vibrant vision research programs in a vision research community at Yale that has undergone an exciting phase of revitalization and expansion, and that has attracted an increasing number of outstanding graduate students and postdoctoral fellows. The proposed training program offers both depth and breadth. The depth derives from its substantive focus on the neuroscience of the eye and the visual system. The breadth of the program derives from the diversity of approaches, spanning molecular, developmental, systems, cognitive and theoretical neuroscience, as well as from the range of experimental models used in these studies, spanning drosophila, zebrafish, rodents, and primates. Faculty interests range from retinal development and degeneration, retinal physiology and circuits to visual cortical function and visual behavior. Methodologies include cloning; cell culture; immunocytochemistry; in situ hybridization; gene transfection and transgenic technology, electron and two photon microscopy; optogenetics, patch-clamp and multielectrode recording; electroretinograph, optical imaging; biochemistry and molecular analyses; psycho-pharmacology; rodent, monkey and human behavior; in vivo extracellular recording in behaving animals; and fMRI and PET imaging in human subjects. Two predoctoral and two postdoctoral positions are requested. Trainees will be selected from a variety of backgrounds in biological sciences on the basis of their potential for excellence and leadership in research by an Executive Committee. Mentors are Ph.D.s and M.D.s. with NEI and other NIH institute grants or NEI related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, laboratory and departmental presentations of research progress, and instructions on responsible research conduct. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page