Effect of Corneal Preservation time on Long-Term Graft Success- Reading Center

CWRU和大学医院眼科研究所的CIARC(前身为SMRC)成立于 20年前，作为一个研究药物效果的企业研究阅读中心， 手术和角膜内皮保存液(43-51)一直是 2000年起为SMAS血管内皮细胞图像分析阅读中心。CIARC已经成为一个 由于开发了内皮图像分类系统，在该领域处于领先地位 采用双重评分和判定的质量和可变框架ECD确定 (2，5-7)在这段时间里，CIARC分析了超过229张眼库图像 和&gt；3000个仅来自SMAS的临床图像集。在过去的三年里，CIARC 将其工作扩展到镜面图像和共焦图像的内皮图像分析 遵循EK(32，42)和形态图像分析技术的应用 与本提案相关的SMAS图像。

The CIARC (formerly SMRC) at CWRU and University Hospitals Eye Institute, established over 20 years ago as a reading center for corporate studies examining the effect of medications, surgery, and preservation media on the corneal endothelium (43-51), has served as the endothelial image analysis reading center for the SMAS since 2000. The CIARC has become a leader in the field as a result of its development of a classification system for endothelial image quality and variable frame ECD determination employing a dual grading and adjudication system.(2, 5-7) Over this period of time the CIARC has analyzed over 229 eye bank images and >3000 clinical image sets from the SMAS alone. In the past three years the CIARC has extended its efforts to endothelial image analysis of both specular and confocal images following EK (32, 42) and the application of morphometric image analysis techniques to the SMAS images which have relevance to this proposal.