Core Center - NIDCD Research Core Center P30

描述(由申请人提供)：NIDCD提供的UW P30研究核心中心赠款为华盛顿大学对NIDCD任务区的大型研究承诺提供了重要的基础设施支持。该研究基地由向15名调查人员提供的15笔赠款组成，每年的直接费用超过300万美元。此外，还包括9笔赠款和1笔K奖、3笔R03赠款和1笔合同，因为它们位于NIDCD任务区。四个研究核心为研究计划提供支持，并促进研究人员之间的互动和合作。核心A，人类受试者招募核心，继续招募和安排符合传播科学和障碍研究特定标准的人类婴儿受试者的长期职能。这一研究核心增加了促进招募有特定听力障碍的受试者的服务。核心B是计算机资源核心(Computer Core)，为人员提供软件开发所需的技能，以便对动物和人类的听觉处理进行实时生理和行为调查。此外，系统和网络管理员还就最佳计算机解决方案向调查人员提供指导和建议。核心C，成像核心，为广泛使用现代数字显微成像方法的项目提供人员和设备维护，包括共焦显微镜、三维重建和细胞属性的定量分析。核心D是遗传学的核心，它控制着研究人员使用近亲繁殖和基因操纵的小鼠品系的育种和DNA筛选。提供了用于快速分析DNA序列的设备，以及用于表型听力和平衡障碍的设备，以提高使用通信障碍小鼠模型进行研究的效率。研究核心由一个行政核心提供支持，该行政核心监督每个研究核心的运作，组织小组会议，提供文书、财政和人事支持，并准备提交给资助机构的报告。

DESCRIPTION (provided by applicant): The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.