Core Center - NIDCD Research Core Center P30

核心中心 - NIDCD 研究核心中心 P30

• 批准号: 8526210
• 负责人: Edwin W Rubel
• 金额: $ 67.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526210
• 关键词: 3-Dimensional; Animals; Area; Auditory; Behavioral; Breeding; Center Core Grants; Collaborations; Communication; Communication impairment; Computers; Confocal Microscopy; Contracts; DNA; DNA Sequence Analysis; Direct Costs; Disease; Educational process of instructing; Equilibrium; Equipment; Funding Agency; Genetic; Grant; Group Meetings; Health; Hearing; Hearing problem; Human; Human Resources; Image; Inbreeding; Infant; Investigation; K-Series Research Career Programs; Lead; Maintenance; Microscopic; Mission; Mouse Strains; National Institute on Deafness and Other Communication Disorders; Phenotype; Physiological; Prevention; Process; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Schedule; Science; Services; Solutions; System; Time; Universities; Washington; base; body system; digital; efficacy research; equilibration disorder; hearing impairment; human subject; imaging modality; improved; meetings; mouse model; operation; programs; ranpirnase; reconstruction; screening; skills; software development

DESCRIPTION (provided by applicant): The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

描述（由申请人提供）：NIDCD的UW P30研究核心中心资助为华盛顿大学对NIDCD任务领域的大型研究承诺提供重要的基础设施支持。研究基地由15笔赠款组成，提供给15名研究人员，每年直接费用超过300万美元。此外，还包括9项赠款和1项k -授、3项R03赠款和1项合同，因为它们属于国家发展和发展战略的任务地区。四个研究核心为研究项目提供支持，并促进研究人员之间的互动和合作。核心A，人类受试者招募核心，继续招募和安排符合交流科学和障碍研究特定标准的人类婴儿受试者的长期功能。这个研究中心增加了一些服务，方便招募有特殊听力障碍的受试者。核心B，计算机资源核心（计算机核心），为人员提供用于动物和人类听觉处理的实时生理和行为调查的软件开发所需的技能。此外，系统和网络管理员还教授并建议调查人员提供最佳计算机解决方案。核心C，成像核心，为广泛使用现代数字显微成像方法的项目提供人员和设备维护，包括共聚焦显微镜、三维重建和细胞属性的定量分析。核心D，基因核心，控制育种和DNA筛选研究人员使用近交和基因操纵小鼠品系。设备用于DNA序列的快速分析，以及听力和平衡障碍的表型分析，以提高使用小鼠交流障碍模型的研究效率。研究核心由行政核心提供支持，行政核心负责监督每个研究核心的运作，组织小组会议，提供文书、财政和人事支持，并向资助机构准备报告。