Core Center--NIDCD Research Core Center P30

描述(由申请人提供)：本文件请求续签华盛顿大学研究核心中心补助金，该补助金为NIDCD任务区的大型研究承诺提供重要的基础设施支持。NIDCD资助的研究基地由向17名调查人员提供的18笔赠款组成，每年的直接费用超过420万美元。此外，还包括对8名调查员的10项补助金和2项K奖，因为他们在NIDCD任务区。四个研究核心为研究计划提供支持，并促进研究人员之间的互动和合作。核心A，人类受试者招募核心，继续招募和安排符合听力和语言感知发展研究特定标准的人类婴儿受试者的长期职能。这个研究核心增加了促进招募有特定听力和知觉障碍的受试者的服务。核心B是计算机资源核心，为人员提供软件开发所需的技能，以便对动物和人类的听觉处理进行实时生理和行为调查。此外，系统和网络管理员还就最佳计算机解决方案向调查人员提供指导和建议。核心C，成像核心，为广泛使用现代数字显微成像方法的项目提供人员和设备维护，包括共焦显微镜、三维重建和细胞属性的定量分析。该核心还支持人脑成像计划。核心D是遗传学的核心，它控制着研究人员使用近亲交配和基因操纵的小鼠品系进行育种和DMA筛查。提供了快速分析DNA序列和胚胎保存的设备，以提高使用通信障碍小鼠模型进行研究的效率。研究核心由一个行政核心提供支持，该行政核心监督每个研究核心的运作，组织小组会议，提供文书、财政和人事支持，并准备提交给资助机构的报告。

DESCRIPTION (provided by applicant): This document requests renewal of the UW Research Core Center Grant that provides important infrastructure support for a large research commitment to the mission area of NIDCD. The NIDCD-funded Research Base is composed of 18 grants to 17 investigators with an annual direct cost of over $4.2 million. In addition, 10 grants and two K-awards to 8 investigators are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on development of hearing and language perception. This Research Core has added services that facilitate recruitment of subjects with specific hearing and perceptual impairments. Core B, the Computer Resources Core, provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. This Core also supports human brain imaging initiatives. Core D, the Genetics Core, controls breeding and DMA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DMA sequences and for embryo preservation to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.