UNIVERSITY OF WASHINGTON RESEARCH CORE CENTER

这是华盛顿大学向NIDCD申请研究核心资助的申请表。NIDCD资助的研究基地由16名研究人员的19笔赠款组成，每年直接费用为33，515，491美元。核心还将为5名NIH资助的研究人员提供基础设施支持，他们的研究是在研究项目中，并刺激新的研究计划。人类受试者招募核心将继续长期存在的婴儿受试者库，这对于人类婴儿和婴儿听力和语言感知发展的研究至关重要。此外，还将建立关于有特定听力和知觉障碍的受试者群体的数据库。计算机资源核心将为人员提供开发软件所需的技能，用于动物和人类听觉处理的实时生理和行为调查。此外，还将聘请一名系统和网络经理，就最佳计算机解决方案向调查人员提供教学和咨询。成像核心将为广泛使用现代数字显微成像方法的项目提供人员和设备维护，包括共聚焦显微镜，三维重建和细胞属性的定量分析。核心还将支持人类大脑成像计划。小鼠遗传学核心将控制育种和DNA筛选的研究人员使用近交系和遗传操纵的小鼠品系。将提供快速分析DNA序列的设备，以提高利用交流障碍小鼠模型进行研究的效率。研究中心将由一个行政中心提供支持，以监督每个研究中心的运作，组织小组会议，提供文书，财政和人事支持，并编写报告给资助机构。

This is the University of Washington application for a Research Core Grant from the NIDCD. The NIDCD funded Research base is composed of 19 grants to 16 investigators supported by $33,515,491 annual direct costs. The Cores will also provide infrastructure support for 5 NIH funded investigators whose research is in research programs, and to stimulate new research initiatives. The Human Subject Recruitment Core will continue a long-standing infant subject pool that is essential for research on the development of hearing and language perception in human infants and babies. Also, databases will be developed on populations of subjects with specific hearing and perceptual impairments. The Computer Resources Core will provide personnel with skills needed for development of software for real-time physiological and behavioral investigations of auditory processing in animals and humans. In addition,, a system and network manager is to be hired to teach and advice investigators on the optimal computer solutions. The Imaging Core will provide personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal Microscopy, 3-dimensional reconstructions and quantitative analyses of cellular attributes. The Core will also support human brain imaging initiatives. The Mouse Genetics Core will control breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment will be provided for rapid analyses of DNA sequences to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores will be supported by an Administrative Core to oversee the operations of each Research Core, organize group meetings, provide clerical, fiscal and personnel support, and prepare reports to funding agency.