Striatal Mechanisms of Ethanol Seeking

项目总结/摘要 习惯性行为并不需要明确的目标表示，而是由 对刺激的自动反应，以前与酒精奖励配对。的确切 这种转变的时间过程尚未确定酒精自我管理，但是， 工具性行为是目标导向的还是习惯性的， 用于确定自我给药是否是习惯性的。目前的建议旨在 测试这一假设，即酒精自我管理后，延长训练将显示 习惯性行为的标志由于条件暗示在复发中也起着重要作用，我们将 还测试了酒精预测线索延长酒精自我管理培训后的效果。 依赖酒精寻求，包括线索促进，对背侧纹状体回路将 被探测。

Project Summary/Abstract Habitual behavior does not require an explicit representation of the goal, but is triggered by automatic responses to the stimuli that previously were paired with alcohol reward. The exact time course of this transition has not been defined for alcohol self-administration, however, there are well-defined tests for whether instrumental behavior is goal-directed or habitual that can be used to determine whether or not self-administration is habitual. The current proposal seeks to test the hypothesis that alcohol self-administration after extended training will display the hallmarks of a habitual behavior. As conditioned cues also play a major role in relapse, we will also test the effects of alcohol-predictive cues after extended alcohol self-administration training. The reliance of alcohol-seeking, including that promoted by cues, on dorsal striatal circuitry will be probed.