Amygdala and Striatal Neural Circuits Controlling Alcohol Intake

杏仁核和纹状体神经回路控制酒精摄入量

• 批准号: 10401866
• 负责人: Patricia H. Janak
• 金额: $ 36.84万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401866
• 关键词: Acute; Alcohol consumption; Alcohol dependence; Alcohols; Amygdaloid structure; Animal Behavior; Anxiety; Behavior; Behavioral; Calcium; Cell Nucleus; Chronic; Cognitive; Consummatory Behavior; Consumption; Corpus striatum structure; Cues; Dependence; Desire for food; Economic Burden; Elements; Ethanol; Event; Fiber; Globus Pallidus; Goals; Health; Human; Hypothalamic structure; Image; Individual; Intake; Interruption; Investigation; Lateral; Liquid substance; Measures; Mediating; Mediation; Mediator of activation protein; Motivation; Neurobiology; Neurons; Nucleus Accumbens; Oral; Pathway interactions; Phase; Photometry; Population; Prosencephalon; Rattus; Regulation; Relapse; Rewards; Role; Self Administration; Specific qualifier value; Stimulus; Study models; Technology; Testing; Thalamic structure; United States; Work; addiction; alcohol abuse therapy; alcohol use disorder; behavior measurement; binge drinking; design; drinking; drinking behavior; feeding; in vivo; in vivo calcium imaging; neural circuit; neuroadaptation; neurobiological mechanism; novel therapeutics; optogenetics; prevent; recruit; relating to nervous system; social

Project Summary/Abstract While considerable effort has been focused upon the neurobiological circuits mediating appetitive, or reward seeking, aspects on alcohol self-administration, our understanding of the circuits that mediate the consummatory aspects – the actual alcohol intake itself – is more limited. Therefore, the studies proposed in this application seek to define the neural circuits that control alcohol intake. These studies build on past work supporting a role for the nucleus accumbens and the amygdala central nucleus both in both natural feeding and in alcohol intake. The contribution of these regions and selected afferents and efferents will be determined using optogenetics to activate or suppress neuronal populations or specific neural projections, and using calcium imaging to query the activity of these neural elements, during cue-elicited and spontaneous alcohol intake. In addition, these studies will examine the impact of prior alcohol dependence on the role of the accumbens and the amygdala central nucleus given the strong evidence for alcohol- induced neuroadaptations in these extended amygdala regions. These studies represent important steps towards specification of consummatory circuits whose function may change after chronic alcohol representing a possible neurobiological mediator of excessive or escalated alcohol intake.

项目总结/摘要 虽然相当多的努力集中在神经生物学回路调解食欲，或奖励 寻求，酒精自我管理的方面，我们对调解的电路的理解， 完成方面-实际酒精摄入量本身-更有限。因此，研究建议 在本申请中试图定义控制酒精摄入的神经回路。这些研究建立在过去 工作支持的作用，核杏仁核和中央核都在两个自然 饮食和酒精摄入。这些区域和选定的传入和传出的贡献将是 使用光遗传学确定以激活或抑制神经元群体或特定神经投射， 并使用钙成像来查询这些神经元素的活动，在线索引发和 自发酒精摄入此外，这些研究将检查先前酒精依赖的影响， 关于杏仁核和杏仁核中央核的作用，因为有强有力的证据表明酒精- 在这些延伸的杏仁核区域诱导神经适应。这些研究是重要的步骤 走向规范慢性饮酒后功能可能发生变化的完善回路 代表过量或升级的酒精摄入的可能神经生物学介质。