Mechanisms of Dopamine Action in Learning: Implications for Addiction
Mechanisms of Dopamine Action in Learning: Implications for Addiction
批准号:
10553236
负责人:
Patricia H. Janak
金额:
$47.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
未结题
起止时间:
2014-04-01 至 2025-01-31
关键词:
Addictive BehaviorAnesthesia proceduresAnimalsAssociation LearningBehaviorBehavior ControlBehavior DisordersBehavioralBrainConceptionsCorpus striatum structureCuesDevelopmentDiseaseDopamineDorsalElectrophysiology (science)ElementsEnvironmentEvolutionFOS geneGoalsHumanHyperphagiaIncentivesInfusion proceduresLearningLightLinkMeasuresMediatingMidbrain structureModelingMovementNeuronsNeurotransmittersNucleus AccumbensOperant ConditioningPathologicPerformancePharmaceutical PreparationsPharmacologyPlayPopulationProcessPsychological reinforcementPublishingRat TransgeneRattusRewardsRoleShapesStimulusSubstance Use DisorderSubstance abuse problemSubstantia nigra structureSystemTestingTimeTrainingVentral Tegmental AreaWorkaddictionapproach behaviorconditioningdopamine systemdopaminergic neurondrug relapsedrug rewarddrug seeking behaviorin vivolearned behaviormesolimbic systemnerve supplyneuralneural patterningneuromechanismneurotransmissionoptogeneticspars compactapsychologicrecruitresponsetransmission process
中文摘要
项目总结
英文摘要
Project summary
Mesolimbic dopamine, along with its ventral striatal targets, plays a major role in
Pavlovian reward learning. Pavlovian reward learning processes underlie many aspects
of drug seeking behavior and play a critical role in drug relapse. Instrumental learning
processes also form a fundamental element of drug seeking behavior, and may depend
on nigrostriatal dopamine innervation of dorsal striatum. Here we seek to understand
how mesolimbic and nigrostriatal dopamine action within striatal targets mediates select
components of reward-seeking behavior, and to test whether interactions between these
systems contribute to normal and pathological reward-seeking behavior. We focus on
dopamine because both natural and drug rewards activate dopamine neurons, and, as
confirmed in our recent findings, dopamine neuron activation, when substituted for
reward, drives specific forms of associative learning implicated in addictive behavior.
Here, using the Th:Cre transgenic rat to limit channelrhodopsin expression to dopamine
neurons, we take advantage of the ability to selectively activate mesolimbic dopamine
neurons to better understand their impact on behavior, neural activity, and integration of
ventral and dorsal striatal systems. We test whether mesolimbic dopamine neuron
reward-related activation recruits more dorsal striatal circuits during specific forms of
learning. A prominent hypothesis posits that reward seeking depends over time on more
dorsal striatal circuits as behavioral control becomes habitual. Thus, we also ask
whether activating mesolimbic dopamine systems can hasten development of habitual
responding for natural or drug reward. In addition, we will determine neural signals
mediating behaviors conditioned by mesolimbic dopamine activation in order to reveal
neural changes in downstream neuronal populations that mediate the performance of
these dopamine-mediated learned behaviors. These studies will provide new information
on the separate and interactive contributions of ventral and dorsal striatal circuits to
reward seeking behavior that can be initiated by dopamine, and are relevant for our
understanding of behavioral disorders involving overeating and substance use disorders.
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From circuits to behaviour in the amygdala.
从杏仁核中的电路到行为。
DOI:
10.1038/nature14188
发表时间:
2015-01-15
期刊:
Nature
影响因子:
64.8
作者:
[Janak PH, Tye KM]
通讯作者:
Tye KM
Dorsomedial Striatal Activity Tracks Completion of Behavioral Sequences in Rats.
背内侧纹状体活动跟踪大鼠行为序列的完成。
DOI:
10.1523/eneuro.0279-21.2021
发表时间:
2021
期刊:
eNeuro
影响因子:
3.4
作者:
[Vandaele,Youna, Ottenheimer,DavidJ, Janak,PatriciaH]
通讯作者:
Janak,PatriciaH
DOI:
10.1101/lm.053472.121
发表时间:
2021-12
期刊:
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子:
--
作者:
[Garr E, Padovan-Hernandez Y, Janak PH, Delamater AR]
通讯作者:
Delamater AR
Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters.
基底外侧杏仁核和眶额皮质,但不是背侧海马,对于控制场合设定者寻求奖励是必需的。
DOI:
10.1007/s00213-022-06227-0
发表时间:
2023
期刊:
Psychopharmacology
影响因子:
3.4
作者:
[Fraser,KurtM, Janak,PatriciaH]
通讯作者:
Janak,PatriciaH
DOI:
10.1038/s41593-018-0191-4
发表时间:
2018-08
期刊:
Nature neuroscience
影响因子:
25
作者:
[Saunders BT, Richard JM, Margolis EB, Janak PH]
通讯作者:
Janak PH
共 13 条
Amygdala neural circuits in alcohol intake
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批准号:10518250
-
项目类别:
-
资助金额:$6.44万
-
财政年份:2019
-
负责人:Patricia H. Janak
-
依托单位:
Amygdala neural circuits in alcohol intake
-
批准号:10362742
-
项目类别:
-
资助金额:$39.49万
-
财政年份:2019
-
负责人:Patricia H. Janak
-
依托单位:
Amygdala neural circuits in alcohol intake
-
批准号:10795152
-
项目类别:
-
资助金额:$6.44万
-
财政年份:2019
-
负责人:Patricia H. Janak
-
依托单位:
Amygdala neural circuits in alcohol intake
-
批准号:10581530
-
项目类别:
-
资助金额:$39.49万
-
财政年份:2019
-
负责人:Patricia H. Janak
-
依托单位:
Amygdala and Striatal Neural Circuits Controlling Alcohol Intake
-
批准号:10401866
-
项目类别:
-
资助金额:$36.84万
-
财政年份:2018
-
负责人:Patricia H. Janak
-
依托单位:
Amygdala and Striatal Neural Circuits Controlling Alcohol Intake
-
批准号:9922827
-
项目类别:
-
资助金额:$36.84万
-
财政年份:2018
-
负责人:Patricia H. Janak
-
依托单位:
Optogenetic Testing of Mechanims of Dopamine Action in Pavlovian Learning
-
批准号:9041564
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项目类别:
-
资助金额:$36.09万
-
财政年份:2015
-
负责人:Patricia H. Janak
-
依托单位:
Optogenetic Testing of Mechanims of Dopamine Action in Pavlovian Learning
-
批准号:9031892
-
项目类别:
-
资助金额:$35.9万
-
财政年份:2015
-
负责人:Patricia H. Janak
-
依托单位:
Mechanisms of Dopamine Action in Learning: Implications for Addiction
-
批准号:10089221
-
项目类别:
-
资助金额:$47.16万
-
财政年份:2014
-
负责人:Patricia H. Janak
-
依托单位:
Mechanisms of Dopamine Action in Learning: Implications for Addiction
-
批准号:9897470
-
项目类别:
-
资助金额:$47.16万
-
财政年份:2014
-
负责人:Patricia H. Janak
-
依托单位:
Mechanisms of Dopamine Action in Learning: Implications for Addiction
-
批准号:10356018
-
项目类别:
-
资助金额:$47.16万
-
财政年份:2014
-
负责人:Patricia H. Janak
-
依托单位:
Optogenetic Testing of Mechanims of Dopamine Action in Pavlovian Learning
-
批准号:8719668
-
项目类别:
-
资助金额:$35.49万
-
财政年份:2014
-
负责人:Patricia H. Janak
-
依托单位:
Pilot Project
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批准号:8794385
-
项目类别:
-
资助金额:$3.39万
-
财政年份:2014
-
负责人:Patricia H. Janak
-
依托单位:
Striatal Mechanisms of Ethanol Seeking
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批准号:8669636
-
项目类别:
-
资助金额:$10.04万
-
财政年份:2013
-
负责人:Patricia H. Janak
-
依托单位:
Context and Relapse to Ethanol-Seeking
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批准号:8675123
-
项目类别:
-
资助金额:$33.33万
-
财政年份:2013
-
负责人:Patricia H. Janak
-
依托单位:
Striatal Mechanisms of Ethanol Seeking
-
批准号:7692958
-
项目类别:
-
资助金额:$34.77万
-
财政年份:2008
-
负责人:Patricia H. Janak
-
依托单位:
Neurochemical Bases for the Rewarding Effects of Ethanol
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批准号:8079065
-
项目类别:
-
资助金额:$35.91万
-
财政年份:2008
-
负责人:Patricia H. Janak
-
依托单位:
Striatal Mechanisms of Ethanol Seeking
-
批准号:8128384
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项目类别:
-
资助金额:$33.73万
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财政年份:2008
-
负责人:Patricia H. Janak
-
依托单位:
Neurochemical Bases for the Rewarding Effects of Ethanol
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批准号:8278024
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项目类别:
-
资助金额:$35.91万
-
财政年份:2008
-
负责人:Patricia H. Janak
-
依托单位:
Striatal Mechanisms of Ethanol Seeking
-
批准号:7919251
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项目类别:
-
资助金额:$35.09万
-
财政年份:2008
-
负责人:Patricia H. Janak
-
依托单位: