Enantioselective Total Synthesis of Communesin F

描述（由申请人提供）：提议的工作将使生物碱天然产物(-)-communesin F的聚合、对映选择性和仿生合成成为可能。(-)-communesin F属于含有结构独特的七环框架的天然产物家族。这类天然产物显示出一系列有趣的生物活性。复杂异源二聚体的生物合成启发重排应该提供共聚生物碱的核心。应用我们新开发的异源二聚化方法可以快速获得所需的二聚体。该方法的核心是络合胺以不对称重氮的形式逐步结合，然后光排出二氮，得到异二聚产物。总之，拟议的路线将

DESCRIPTION (provided by applicant): The proposed work would enable the convergent, enantioselective, and biomimetic synthesis of the alkaloid natural product (-)-communesin F. (-)-Communesin F belongs to a family of natural products containing a structurally unique heptacyclic framework. This family of natural products displays a range of interesting biological activities. A biosynthetically inspired rearrangement of a complex heterodimer should afford the core of the communesin alkaloids. Application of our newly developed method for heterodimerization will allow rapid access to the necessary dimer. The method centers on the stepwise union of complex amines in the form of unsymmetrical diazenes followed by photoexpulsion of dinitrogen to afford the heterodimerized product. In all, the proposed route will afford a rapid and convergent synthesis of (-)- communesin F which potentially could be expanded to all members of the communesin family of natural products.