Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development
便携式芯片实验室流式细胞仪:原型和应用开发
基本信息
- 批准号:8463572
- 负责人:
- 金额:$ 47.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-01 至 2014-04-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAdoptedAlgorithmsArchitectureBiomedical ResearchCalculiCell LineCell SeparationCell surfaceCellsClinicalCodeColorConsultationsDatabasesDetectionDevelopmentDevicesDiagnosticDigital Signal ProcessingDiscriminationElectronicsEngineeringEvaluationEventEyeFlow CytometryFluorescenceFundingFutureGoalsHumanImprove AccessInjection of therapeutic agentInstitutesLeftLegal patentLifeLiquid substanceMedicineMethodsMetricMicrofluidicsModelingMoldsNoisePerformancePhasePhotoreceptorsPopulationPriceProcessProductionPropertyResearchResearch InstituteResearch PersonnelRunningSideSignal TransductionSorting - Cell MovementSpeedSystemTechniquesTechnologyTestingTimeTravelTreesTubeUnited States National Institutes of HealthWeightWorkanticancer researchbasecell behaviorcell typeclinical applicationcolor detectioncommercializationcomputerized data processingcostdesigndetectorimprovedinnovationinstrumentmanufacturing processmeetingsmicro-total analysis systemoperationoutcome forecastparticlephotomultiplierpoint of careprogramsprototyperesearch studyshear stresssuccesswasting
项目摘要
DESCRIPTION (provided by applicant): Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development NanoSort RESEARCH & RELATED Other Project Information 7. PROJECT SUMMARY The lab-on-a-chip NanoSort device proposed here advances the achievements of the Phase I Beta Prototype project. This device will be appropriate for commercial success by improving access to and reducing the cost and complexity of sorting flow cytometry. Furthermore, it will expand the applications that this device can serve, including translational and clinical point-of-care flow cytometry applications for diagnostics, prognosis, and personalized medicine. Having completed key milestones in the Phase I program, such as mas- producible injection molded chips, advanced signal detection and processing and key performance metrics, we propose to extend the capabilities to compete with best-in-class devices. Our Aims for this project are to create a device (NanoSort-1 or NS-1) that will have improved performance parameters of 6-color detection with a single photomultiplier tube (PMT), 4-way sorting using low shear stress piezoelectric (PZT) actuators, and a robust digital signal processing algorithm (Color-Space-Time (CoST) implementation that allows 10,000 events per second detection and sorting. In addition to these innovations, we will construct the device using current good manufacturing processes (cGMP) to assure that this device will be UL and CE certified and scalable to 10,000 units per year. We will validate this device with consultation from established researchers at UCSD and device manufactures (Becton-Dickinson and Life Technologies).
描述(由申请人提供):便携式芯片实验室流式细胞仪:原型和应用开发NanoSort研究及相关其他项目信息7.项目概述这里提出的芯片实验室NanoSort设备推进了第一阶段Beta原型项目的成就。该装置将通过改善分选流式细胞术的可及性并降低分选流式细胞术的成本和复杂性而适合于商业成功。此外,它将扩展该设备可以服务的应用,包括用于诊断,预后和个性化医疗的转化和临床即时流式细胞术应用。在完成第一阶段计划的关键里程碑后,如可量产的注塑芯片、先进的信号检测和处理以及关键性能指标,我们建议扩展与同类最佳设备竞争的能力。我们这个项目的目标是创建一个设备(NanoSort-1或NS-1),将有一个单一的光电倍增管(PMT),使用低剪切应力压电(PZT)驱动器的4路分选6色检测改进的性能参数,和一个强大的数字信号处理算法(颜色-空间-时间(CoST)的实现,允许每秒10,000个事件的检测和排序。除了这些创新之外,我们还将使用当前的良好制造工艺(cGMP)来构建设备,以确保该设备将获得UL和CE认证,并可扩展到每年10,000台。我们将通过咨询UCSD和器械制造商(Becton-Dickinson和Life Technologies)的知名研究人员来验证该器械。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yu-Hwa Lo其他文献
Yu-Hwa Lo的其他文献
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{{ truncateString('Yu-Hwa Lo', 18)}}的其他基金
Universal Precision Tool for Single Cell Capture, Conditioning, and Dispensing
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- 批准号:
8704429 - 财政年份:2013
- 资助金额:
$ 47.36万 - 项目类别:
Universal Precision Tool for Single Cell Capture, Conditioning, and Dispensing
用于单细胞捕获、调节和分配的通用精密工具
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Universal Precision Tool for Single Cell Capture, Conditioning, and Dispensing
用于单细胞捕获、调节和分配的通用精密工具
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8843898 - 财政年份:2013
- 资助金额:
$ 47.36万 - 项目类别:
Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
使用颜色时空 (COST) 编码方法的芯片实验室流式细胞仪
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8123538 - 财政年份:2011
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$ 47.36万 - 项目类别:
Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
使用颜色时空 (COST) 编码方法的芯片实验室流式细胞仪
- 批准号:
8290279 - 财政年份:2011
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$ 47.36万 - 项目类别:
Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
使用颜色时空 (COST) 编码方法的芯片实验室流式细胞仪
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8455193 - 财政年份:2011
- 资助金额:
$ 47.36万 - 项目类别:
Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development
便携式芯片实验室流式细胞仪:原型和应用开发
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8252284 - 财政年份:2010
- 资助金额:
$ 47.36万 - 项目类别:
Portable Lab-on-a-chip Flow Cytometer: Prototype and Application Development
便携式芯片实验室流式细胞仪:原型和应用开发
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An Integrated lab-on-chip system for genome sequencing of single microbial cells
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7572234 - 财政年份:2008
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