Multidisciplinary Training Program in Hypertension

描述（由申请人提供）：鉴于美国高血压发病率的上升，以及血压升高与心血管发病率和死亡率之间的密切关系，显然需要未来的高血压研究人员。这是佛罗里达大学“高血压多学科培训计划”的第一个竞争性延续申请。T32由UF高血压中心管理，研究计划围绕以下主要重叠主题组织，反映了指导教师的专业知识：内皮损伤和修复;血管张力和BP的神经控制;血压的中枢和外周血管紧张素II和一氧化氮控制;肺动脉高压;心血管损伤和肾脏疾病;运动和心血管损伤与健康;高血压与衰老/性二型性;高血压与肥胖;妊娠期高血压;高血压的发育起源;抗高血压治疗的药物基因组学方法。有27资金充足，潜在的导师从11个部门/部门在工程，健康和人类表现，医学和药学的UF学院绘制和许多这些导师正在积极合作。Chris Baylis博士是UF高血压中心和T32项目主任的主任。Peter Sayeski博士，将成为副主任。该计划的一般监督是由内部咨询委员会和外部咨询委员会，由凯瑟琳桑德伯格博士主持。（Georgetown University）由PD和招聘和审查（R@R）委员会招聘和监控受训人员的进展。高血压中心通过以下活动为T32学员提供关注和支持：每月高血压中心系列研讨会; Sandberg博士年度访视的费用;每位学员培训期间每位外部导师1次访视的费用。培训方案强调所有受训人员都需要有效沟通，通过参加期刊俱乐部来完成;在所有活跃的导师，PD和R@R委员会以及年度T32务虚会的内部和外部咨询委员会面前每年两次口头介绍;在主要联系部门的研讨会系列中进行年度介绍;参加每周的实验室会议，出席国家和国际会议并发表演讲。这T32目前资助3名博士前学生和3名博士后学员。在这个项目的前5年，我们毕业了4个博士学位。受训人员（3人现在博士后，1人返回医学院），3人正在受训。我们培养了4名博士后研究员（一名医学博士）。两个博士现在是助理教授和一个博士。目前正在学术界或工业界寻求研究职位。我们要求继续提供这一数量的奖学金（3名博士前和3名博士后）。我们正在申请2级、3级和4级的博士后津贴，以适应一些医学博士的招聘。实习生

DESCRIPTION (provided by applicant): Given the rising incidence of hypertension in the US, and the strong relationship between elevated blood pressure and cardiovascular morbidity and mortality, there is a clear need for future hypertension researchers. This is the first competing continuation application of the University of Florida's "Multidisciplinary Training Program in Hypertension". The T32 is administered by the UF Hypertension Center and the research program is organized around the following major overlapping themes that reflect the expertise of the mentoring faculty: Endothelial injury and repair; neural control of vascular tone and BP; central and peripheral angiotensin II and nitric oxide control of blood pressure; pulmonary hypertension; cardiovascular damage and renal disease; exercise and cardiovascular injury and health; hypertension and aging/ sexual dimorphism; hypertension and obesity; hypertension in pregnancy; developmental origins of hypertension; pharmacogenomic approaches to antihypertensive treatments. There are 27 well funded, potential mentors drawn from 11 Departments/ Divisions in the UF Colleges of Engineering, Health and Human Performance, Medicine and Pharmacy and many of these mentors are actively collaborating. Chris Baylis Ph.D. is the director of the UF Hypertension Center and T32 Program Director. Peter Sayeski Ph.D., will become Associate director. General oversight of the program is by the Internal Advisory committee and External Advisory committee, chaired by Kathryn Sandberg, Ph.D. (Georgetown University). Recruitment and monitoring of trainee progress is by the PD and the Recruitment and Review (R@R) committee. The Hypertension Center provides the focus and support to the T32 trainees with the following activities: Monthly Hypertension Center seminar series; costs for annual visits of Dr. Sandberg; costs for 1 visit of each external mentor during training period of each trainee. The training program emphasizes the need for all trainees to effectively communicate, accomplished by participation in Journal Club; oral presentations twice a year before all active mentors, PD and the R@R committee and also before both internal and external advisory committees at the annual T32 retreats; annual presentations in the seminar series of the Department of primary affiliation; participation in weekly lab meetings and by attendance and presentation at national and international meetings. This T32 currently funds 3 predoctoral students and 3 postdoctoral trainees. During the first 5 years of this program we graduated 4 Ph.D. trainees (3 now in postdoctoral positions and 1 returned to medical school) with 3 in training. We have trained 4 postdoctoral fellows (an M.D. and 2 Ph.D.s who are now Assistant Professors and a Ph.D. who is currently seeking a research position in academia or industry. We are requesting that this number of stipends (3 predoctoral and 3 postdoctoral) be continued. We are requesting postdoctoral stipends at levels 2, 3 and 4 to accommodate recruitment of some M.D. trainees.