Multidisciplinary Training Program in Hypertension

描述（由申请人提供）：鉴于美国高血压发病率的上升，以及血压升高与心血管疾病发病率和死亡率之间的密切关系，显然需要未来的高血压研究人员。这是佛罗里达大学“高血压多学科培训项目”的第一个竞争性延续应用。T32由UF高血压中心管理，研究项目围绕以下主要重叠主题组织，反映了指导教师的专业知识：内皮损伤和修复；血管张力和血压的神经控制；中央和外周血管紧张素II和一氧化氮控制血压；肺动脉高压;心血管损伤和肾脏疾病；运动与心血管损伤与健康；高血压和衰老/两性异形；高血压和肥胖；妊娠期高血压；高血压的发育起源；抗高血压治疗的药物基因组学方法。在佛罗里达大学工程学院、健康与人类绩效学院、医学与药学学院的11个部门中，有27位资金充足的潜在导师，其中许多导师正在积极合作。克里斯·贝利斯博士是佛罗里达大学高血压中心主任和T32项目主任。Peter Sayeski博士将成为副主任。该项目的总体监督由内部咨询委员会和外部咨询委员会负责，由乔治城大学的凯瑟琳·桑德伯格博士担任主席。培训专员及招聘及检讨（R@R）委员会负责招聘及监察见习人员的进度。高血压中心通过以下活动为T32学员提供关注和支持：每月高血压中心系列讲座；桑德伯格医生每年出诊的费用；培训期间每位外部导师1次拜访费用。培训计划强调所有受训者需要通过参与期刊俱乐部来实现有效的沟通；每年两次在所有在职导师，PD和R@R委员会面前进行口头报告，并在年度T32务虚会上向内部和外部咨询委员会进行口头报告；在初级隶属部门系列研讨会上的年度报告；参加每周一次的实验室会议，并在国内和国际会议上发表演讲。该项目目前资助3名博士生和3名博士后。在这个项目的前5年，我们毕业了4名博士生（3名现在在博士后职位，1名回到医学院），3名在培训中。培养博士后4人（医学博士1人，博士2人），现为助理教授，博士1人，正在学术界或产业界寻找研究岗位。我们请求保持这个数量的奖学金（3名博士预科生和3名博士后）。我们要求提供2级、3级和4级博士后津贴，以便招聘一些医学博士学员。

DESCRIPTION (provided by applicant): Given the rising incidence of hypertension in the US, and the strong relationship between elevated blood pressure and cardiovascular morbidity and mortality, there is a clear need for future hypertension researchers. This is the first competing continuation application of the University of Florida's "Multidisciplinary Training Program in Hypertension". The T32 is administered by the UF Hypertension Center and the research program is organized around the following major overlapping themes that reflect the expertise of the mentoring faculty: Endothelial injury and repair; neural control of vascular tone and BP; central and peripheral angiotensin II and nitric oxide control of blood pressure; pulmonary hypertension; cardiovascular damage and renal disease; exercise and cardiovascular injury and health; hypertension and aging/ sexual dimorphism; hypertension and obesity; hypertension in pregnancy; developmental origins of hypertension; pharmacogenomic approaches to antihypertensive treatments. There are 27 well funded, potential mentors drawn from 11 Departments/ Divisions in the UF Colleges of Engineering, Health and Human Performance, Medicine and Pharmacy and many of these mentors are actively collaborating. Chris Baylis Ph.D. is the director of the UF Hypertension Center and T32 Program Director. Peter Sayeski Ph.D., will become Associate director. General oversight of the program is by the Internal Advisory committee and External Advisory committee, chaired by Kathryn Sandberg, Ph.D. (Georgetown University). Recruitment and monitoring of trainee progress is by the PD and the Recruitment and Review (R@R) committee. The Hypertension Center provides the focus and support to the T32 trainees with the following activities: Monthly Hypertension Center seminar series; costs for annual visits of Dr. Sandberg; costs for 1 visit of each external mentor during training period of each trainee. The training program emphasizes the need for all trainees to effectively communicate, accomplished by participation in Journal Club; oral presentations twice a year before all active mentors, PD and the R@R committee and also before both internal and external advisory committees at the annual T32 retreats; annual presentations in the seminar series of the Department of primary affiliation; participation in weekly lab meetings and by attendance and presentation at national and international meetings. This T32 currently funds 3 predoctoral students and 3 postdoctoral trainees. During the first 5 years of this program we graduated 4 Ph.D. trainees (3 now in postdoctoral positions and 1 returned to medical school) with 3 in training. We have trained 4 postdoctoral fellows (an M.D. and 2 Ph.D.s who are now Assistant Professors and a Ph.D. who is currently seeking a research position in academia or industry. We are requesting that this number of stipends (3 predoctoral and 3 postdoctoral) be continued. We are requesting postdoctoral stipends at levels 2, 3 and 4 to accommodate recruitment of some M.D. trainees.