EIT: a non-radiating functional imaging method for cystic fibrosis

EIT：囊性纤维化的非辐射功能成像方法

• 批准号: 8638305
• 负责人: Jennifer Lynn Mueller
• 金额: $ 21.78万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8638305
• 关键词: Acute; Admission activity; Adult; Adverse effects; Aftercare; Air; Algorithms; Antibiotic Therapy; Antibiotics; Atelectasis; Body Surface; Child; Chronic lung disease; Cities; Clinical; Computer software; Cystic Fibrosis; Data; Diagnosis; Effectiveness; Electrodes; Exposure to; Feedback; Frequencies; Functional Imaging; Goals; Gold; Hospitalization; Image; Imaging Techniques; Imaging technology; Individual; Ionizing radiation; Knowledge; Longevity; Lung; Measures; Mucous body substance; Nature; Obstruction; Oral; Patient Care; Patient Outcomes Assessments; Patients; Positioning Attribute; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary function tests; Radiation; Research; Risk; Sedation procedure; Sensitivity and Specificity; Side; Spirometry; Surveys; Symptoms; System; Technology; Testing; Time; Venous; X-Ray Computed Tomography; cystic fibrosis patients; electric impedance; experience; imaging modality; improved; infancy; interest; lung imaging; public health relevance; reconstruction; software systems; tomography; voltage

Project Summary Individuals with chronic lung disease often have conditions that are very dicult to diagnose without the aid of imaging technology. The gold standard, CT scanning, exposes the patient to ionizing radiation and may be harmful in children. Electrical impedance tomography (EIT) is a noninvasive, non-ionizing functional imaging technique in which electrodes are placed on the surface of the body, and low amplitude, low frequency current is applied on the electrodes. This results in a voltage distribution on the electrodes which can then be measured. From these voltages, an image is formed that re ects the conductivity and/or permittivity distribution within the region of interest. Since EIT is a safe and portable technology with no damaging side e ects, it can be used as needed. This project is part of a long term goal to develop an EIT system for imaging patients with chronic lung disease. The goal of this research is to determine whether electrical impedance tomography can provide a means to obtain quantitative and regional information about the extent and nature of bronchial obstruction in patients with cystic brosis (CF). In particular, EIT will be used to identify regions of obstruction (air trapping) and consolidation comprised of atelectasis and airway occlusion in CF patients, and to correlate these measures with improvements seen after hospitalized treatment for a pulmonary exacerbation. The rst speci c aim is to develop algorithms for quantifying bronchial obstruction and consolidation and to determine their sensitivity and speci city. The algorithms will extract information from EIT images of conductivity and permittivity computed using the D-bar reconstruction algorithm developed by the P.I. Data will be collected during spirometry on CF patients clinically indicated for CT scans and on subjects with healthy lungs, and the sensitivity and speci city of the algorithms will be determined using both the data from the healthy subjects and data calculated from CT VIDA Software. The second speci c aim is to determine whether these algorithms can demonstrate the bene cial e ects of antibiotic treatment for CF patients with an acute PE by correlating changes in quantitative EIT measures with clinical measures known to improve following therapy, with patients serving as their own controls. Regional changes in air trapping and consolidation from pre to post treatment as indicated by the EIT images will be calculated, with subjects serving as their own control.

项目摘要 慢性肺病患者的病情往往很难诊断 没有成像技术的帮助。黄金标准，CT扫描，使患者暴露于 电离辐射，可能对儿童有害。电阻抗断层成像（EIT）是一种 一种非侵入性、非电离功能成像技术，其中电极放置在表面上 在电极上施加低振幅、低频电流。这导致 然后可以测量电极上的电压分布。根据这些电压， 形成图像，该图像反映了该区域内的电导率和/或电容率分布， 兴趣由于EIT是一种安全、便携的技术，没有破坏性的副作用，因此可以使用 根据需要这个项目是一个长期目标的一部分，开发一个成像病人的EIT系统 患有慢性肺病 本研究的目的是确定电阻抗断层成像是否可以提供 一种获得有关支气管炎程度和性质的定量和区域信息的方法， 囊性纤维化（CF）患者的梗阻。特别是，EIT将用于识别区域 阻塞（空气滞留）和实变，包括CF中的肺不张和气道阻塞 患者，并将这些措施与住院治疗后的改善相关联， 肺部恶化第一个具体目标是开发量化支气管的算法， 并确定其敏感性和特异性。算法将 从使用D-bar计算的电导率和介电常数的EIT图像中提取信息 由P.I.将在CF肺功能测定期间收集数据 临床上适用于CT扫描的患者和肺部健康的受试者，以及 将使用来自健康受试者的数据 数据由CT维达软件计算。第二个具体目标是确定 这些算法可以证明抗生素治疗CF患者的贝内， 通过将定量EIT指标的变化与已知的临床指标相关联， 以患者作为自身对照，改善后续治疗。空气的区域变化 如EIT图像所示，从治疗前到治疗后的陷获和固结将 计算，受试者作为自己的控制。