EIT: a non-radiating functional imaging method for cystic fibrosis

EIT：囊性纤维化的非辐射功能成像方法

• 批准号: 8741735
• 负责人: Jennifer Lynn Mueller
• 金额: $ 15.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8741735
• 关键词: Acute; Admission activity; Adult; Adverse effects; Aftercare; Air; Algorithms; Antibiotic Therapy; Antibiotics; Atelectasis; Body Surface; Child; Chronic lung disease; Cities; Clinical; Computer software; Cystic Fibrosis; Data; Diagnosis; Effectiveness; Electrodes; Exposure to; Feedback; Frequencies; Functional Imaging; Goals; Gold; Hospitalization; Image; Imaging Techniques; Imaging technology; Individual; Ionizing radiation; Knowledge; Longevity; Lung; Measures; Mucous body substance; Nature; Obstruction; Oral; Patient Care; Patient Outcomes Assessments; Patients; Positioning Attribute; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary function tests; Radiation; Research; Risk; Sedation procedure; Sensitivity and Specificity; Side; Spirometry; Surveys; Symptoms; System; Technology; Testing; Time; Venous; X-Ray Computed Tomography; cystic fibrosis patients; electric impedance; experience; imaging modality; improved; infancy; interest; lung imaging; public health relevance; reconstruction; software systems; tomography; voltage

DESCRIPTION (provided by applicant): Individuals with chronic lung disease often have conditions that are very difficult to diagnose without the aid of imaging technology. The gold standard, CT scanning, exposes the patient to ionizing radiation and may be harmful in children. Electrical impedance tomography (EIT) is a noninvasive, non-ionizing functional imaging technique in which electrodes are placed on the surface of the body, and low amplitude, low frequency current is applied on the electrodes. This results in a voltage distribution on the electrodes which can then be measured. From these voltages, an image is formed that re acts the conductivity and/or permittivity distribution within the region of interest. Since EIT is a saf and portable technology with no damaging side effects, it can be used as needed. This project is part of a long term goal to develop an EIT system for imaging patients with chronic lung disease. The goal of this research is to determine whether electrical impedance tomography can provide a means to obtain quantitative and regional information about the extent and nature of bronchial obstruction in patients with cystic fibrosis (CF). In particular, EIT will be used to identify regions of obstruction (air trapping) and consolidation comprised of atelectasis and airway occlusion in CF patients, and to correlate these measures with improvements seen after hospitalized treatment for a pulmonary exacerbation. The first specific aim is to develop algorithms for quantifying bronchial obstruction and consolidation and to determine their sensitivity and specificity. The algorithms will extract information from EIT images of conductivit and permittivity computed using the D-bar reconstruction algorithm developed by the P.I. Data will be collected during spirometry on CF patients clinically indicated for CT scans and on subjects with healthy lungs, and the sensitivity and specificity of the algorithms will be determined using both the data from the healthy subjects and data calculated from CT VIDA Software. The second specific aim is to determine whether these algorithms can demonstrate the beneficial effects of antibiotic treatment for CF patients with an acute PE by correlating changes in quantitative EIT measures with clinical measures known to improve following therapy, with patients serving as their own controls. Regional changes in air trapping and consolidation from pre to post treatment as indicated by the EIT images will be calculated, with subjects serving as their own control.

描述（由申请人提供）：患有慢性肺病的个体通常患有在不借助成像技术的情况下很难诊断的病症。 CT 扫描这一黄金标准会使患者暴露于电离辐射下，可能对儿童有害。电阻抗断层扫描 (EIT) 是一种无创、非电离功能成像技术，将电极放置在身体表面，并向电极施加低振幅、低频电流。这会产生电极上的电压分布，然后可以测量该电压分布。根据这些电压，形成反映感兴趣区域内的电导率和/或介电常数分布的图像。由于 EIT 是一种安全、便携的技术，没有破坏性的副作用，因此可以根据需要使用。该项目是开发用于慢性肺病患者成像的 EIT 系统的长期目标的一部分。本研究的目的是确定电阻抗断层扫描是否可以提供一种方法来获取有关囊性纤维化 (CF) 患者支气管阻塞的程度和性质的定量和区域信息。特别是，EIT 将用于识别 CF 患者中由肺不张和气道闭塞组成的阻塞（空气滞留）和实变区域，并将这些措施与肺部病情加重住院治疗后的改善联系起来。第一个具体目标是开发量化支气管阻塞和实变的算法，并确定其敏感性和特异性。该算法将从使用 P.I. 开发的 D-bar 重建算法计算的电导率和介电常数 EIT 图像中提取信息。将在肺活量测定期间收集临床上需要进行 CT 扫描的 CF 患者和具有健康肺部的受试者的数据，并且将使用来自健康受试者的数据和 CT VIDA 软件计算的数据来确定算法的敏感性和特异性。第二个具体目标是确定这些算法是否可以通过将定量 EIT 测量的变化与已知可改善后续治疗的临床测量相关联，并以患者作为自己的对照来证明抗生素治疗对患有急性 PE 的 CF 患者的有益效果。将计算 EIT 图像所指示的从治疗前到治疗后的空气滞留和固结的区域变化，并以受试者作为自己的对照。

项目成果

Incorporating a Spatial Prior into Nonlinear D-Bar EIT Imaging for Complex Admittivities.

• DOI: 10.1109/tmi.2016.2613511
• 发表时间: 2017-02
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Hamilton SJ;Mueller JL;Alsaker M
• 通讯作者: Alsaker M

Evaluation of surrogate measures of pulmonary function derived from electrical impedance tomography data in children with cystic fibrosis.

• DOI: 10.1088/1361-6579/aab8c4
• 发表时间: 2018-04-26
• 期刊: Physiological measurement
• 影响因子: 3.2
• 作者: Muller PA;Mueller JL;Mellenthin M;Murthy R;Capps M;Wagner BD;Alsaker M;Deterding R;Sagel SD;Hoppe J
• 通讯作者: Hoppe J

A Real-time D-bar Algorithm for 2-D Electrical Impedance Tomography Data.

• DOI: 10.3934/ipi.2014.8.1013
• 发表时间: 2014-11-01
• 期刊: Inverse problems and imaging (Springfield, Mo.)
• 作者: Dodd M;Mueller JL
• 通讯作者: Mueller JL

Estimating regions of air trapping from electrical impedance tomography data.

• DOI: 10.1088/1361-6579/aac295
• 发表时间: 2018-05-31
• 期刊: Physiological measurement
• 影响因子: 3.2
• 作者: Mueller JL;Muller P;Mellenthin M;Murthy R;Capps M;Alsaker M;Deterding R;Sagel SD;DeBoer E
• 通讯作者: DeBoer E