Combined Multi-Pinhole and Fan-Beam Brain SPECT

结合多针孔和扇束脑 SPECT

• 批准号: 8583876
• 负责人: Michael A King
• 金额: $ 24.98万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8583876
• 关键词: Address; Beds; Binding; Biological Models; Brain; Brain imaging; Brain region; Breast; Caliber; Cardiac; Cephalic; Clinical; Code; Collimator; Computer software; Corpus striatum structure; Coupled; Data; Detection; Diagnosis; Disease; Early Diagnosis; Evaluation; Financial compensation; Funding; Goals; Head; Heart; Image; Imagery; Imaging Techniques; Investigation; Label; Lateral; Limb structure; Monitor; Occipital lobe; Parathyroid gland; Parkinson Disease; Patients; Penetration; Performance; Perfusion; Photons; Positron-Emission Tomography; Price; Procedures; Prostate; Relative (related person); Resolution; Sampling; Structure; Substantia nigra structure; System; Testing; Thyroid Gland; Time; Variant; attenuation; base; bone imaging; clinical application; cost; design; design and construction; detector; high risk; improved; innovation; interest; irradiation; meetings; nervous system disorder; public health relevance; putamen; reconstruction; simulation; single photon emission computed tomography; uptake; web site

DESCRIPTION (provided by applicant): The recent FDA approval of the SPECT imaging agent I-123 labeled DaTscan for diagnosis and monitoring progression of Parkinson's Disease (PD) has open up a new era in SPECT brain imaging. Unlike with perfusion imaging where the entire brain is the volume of interest, with PD the structures of interest are the putamen and caudate (and potentially substantia nigra) which lie in the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding rati (SBR), a parameter of significance in the early diagnosis and differentiation of PD from other disorders with similar clinical presentations. Our hypothesis is that combining a specifically designed MPH collimator on one detector head with a fan-beam collimator on the remaining head of current dual-headed SPECT systems, coupled with iterative reconstruction with modeling system spatial resolution, will result in improved detection and quantification of structures in the interior region of the brain at marginal cost (the price of collimator(s) and reconstruction software). The MPH collimator would be designed to provide enhanced spatial resolution / sensitivity for the interior of the brain. The fan-beam collimator would provide lower resolution but complete sampling of the brain addressing data sufficiency and allowing a volume-of-interest to be defined over the occipital lobe for calculation of SBR's. Clinically this would provide a low-cost system allowing improved visualization and relative quantification of function of structures in the interior region of the brain, potentially as small as the ~4 mm substantia nigra, which cannot currently be achieved by other than expensive, brain dedicated, SPECT systems. This would greatly impact the early detection and differentiation of PD, and possibly other neurological disorders as new SPECT imaging agents are approved. Our approach for investigating our hypothesis is organized into two specific aims. The first specific aim is to select the MPH collimator designs to be compared under the second specific aim by task-based performance studies, and develop the combined reconstruction of MPH and fan-beam collimators to enable this comparison. The second specific aim is to perform task-based optimization and then comparison of the selected designs based on detection using the Channelized Hoteling Observer (CHO) and quantification of striatal function by calculation of the SBR. Using these task-based criteria we will investigate the trade-off of resolution versus sensitivity by variation in the diameter of the pinholes, and ways to improve sensitivity through judicious usage of not enforcing uniqueness in the portion of the detector irradiated by each pinhole (allowing multiplexing), and curvature of the plate the pinholes are mounted on to bring the lateral and cranial pinholes closer to the patient.

描述（由申请人提供）：SPECT成像剂I-123标记为DATSCAN的FDA批准，用于诊断和监测帕金森氏病（PD）的诊断和监测，已在Spect Brain Imaging中开辟了一个新时代。与灌注成像不同的是，整个大脑是感兴趣的体积，PD感兴趣的结构是位于大脑内部部分的壳核和尾状（以及潜在的黑核酸）。但是，PD还需要对枕叶的成像进行计算，以计算纹状体结合RATI（SBR），这是PD与其他具有相似临床表现的疾病的早期诊断和分化显着性的参数。我们的假设是，将一个特定设计的MPH直接仪与一个探测器头上设计的MPH直接发电机与剩余的当前双头Spect系统的剩余头部结合在一起，再加上迭代的重建以及建模系统空间分辨率，将导致改善大脑在Marginal Codection（Comerimator）（S）和Recons（S）和Recons（S）中的结构区域的检测和定量。 MPH准直仪的设计旨在为大脑内部提供增强的空间分辨率 /灵敏度。风扇梁直接仪将提供较低的 分辨率但对大脑的完整采样，以解决数据的充分性，并允许在枕叶上定义利益，以计算SBR。从临床上讲，这将提供一个低成本的系统，可以改善大脑内部区域内结构功能的可视化和相对量化，这可能与〜4 mm底底底底，目前无法通过其他昂贵的大脑专用Spect System Systems来实现。这将极大地影响PD的早期检测和分化，并可能随着新的SPECT成像剂的批准，可能会影响其他神经系统疾病。我们调查假设的方法被组织为两个具体目标。第一个具体目的是选择基于任务的绩效研究在第二个特定目的下进行比较的MPH准直仪设计，并开发MPH和风扇束准直仪的联合重建以实现此比较。第二个具体目的是使用渠道化的酒店观察者（CHO）进行基于任务的优化，然后基于检测的选定设计进行比较，并通过计算SBR对纹状体功能进行量化。使用这些基于任务的标准，我们将研究分辨率与敏感性的权衡，而定位插孔的直径变化，以及通过明智地使用不强制执行探测器的唯一用法来提高灵敏度的方法，而每个刺射的部分（允许多发性多重）（允许多发性多重）和弯曲的pin孔固定在pin孔上，并将其固定在pin孔上。