Core 1: PRACTICE Shared Resource Core

核心1：实践共享资源核心

• 批准号: 10328040
• 负责人: Debra L. Friedman
• 金额: $ 33.13万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328040
• 关键词: Address; Area; Behavioral Sciences; Biometry; Breast; Breast Cancer Risk Factor; Cancer Center; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Community Developments; Conduct Clinical Trials; Continuity of Patient Care; Coupled; Data; Disease; Early Diagnosis; Educational Materials; Enrollment; Epidemiology; Etiology; Evaluation; Exclusion Criteria; Experimental Designs; Future; General Hospitals; Goals; Health; Healthcare; Incidence; Information Dissemination; Infrastructure; Institution; Intervention; Intervention Trial; Investigator-Initiated Research; Learning; Link; Logic; Longitudinal cohort; Lung; Malignant Neoplasms; Mentorship; Methods; Minority Access; Mission; Modeling; Observational Study; Oncology; Outcome; Palliative Care; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Population Research; Population Sciences; Prevention; Public Hospitals; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Risk Assessment; Risk Factors; Science; Screening for cancer; Self Management; Students; Supportive care; Tennessee; Therapeutic Clinical Trial; Time; Training; Trust; Underserved Population; Universities; Woman; Work; anticancer research; base; behavioral health; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer therapy; care delivery; clinical infrastructure; cohort; community engaged research; community engagement; comorbidity; control trial; design; education research; ethnic minority population; improved; inclusion criteria; lung cancer screening; malignant breast neoplasm; medical schools; metropolitan; mortality; neoplasm registry; outreach; patient population; population based; pre-doctoral; prospective; racial minority; recruit; research study; safety net; success; survivorship; tobacco control; trial design

PROJECT SUMMARY: PRACTICE SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, we must augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. We propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum, illustrated in three thematic domains focused on decreasing cancer health disparities: prevention and early detection; interventional trials and observational studies during and following treatment; implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Core will address the following aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目总结：实践共享资源核心 癌症公平(实践)共享资源核心中的拟议人群研究和临床试验 将建立在现有临床试验核心(CTC)的基础设施上，该核心已为 Meharry/Vanderbilt-Ingram癌症中心/田纳西州癌症伙伴关系(MVTCP)自 盗梦空间。虽然CTC在将临床试验带到纳什维尔的患者基地方面发挥了重要作用 位于梅哈里医学院(MMC)的综合医院(NGH)，更全面地解决癌症健康问题 为了消除差距，我们必须加强这些努力，开展预防、早期发现、治疗、 纳什维尔大都会统计区(MSA)的生存和姑息治疗，由我们的 伙伴关系。我们建议建立实践共享资源核心，进一步造福NGH 患者基础，促进研究人员发起的研究，并将伙伴关系的覆盖范围扩大到服务不足的人 在纳什维尔海事局。MVTCP在人口科学研究方面拥有强大的实力，这将促进 现有的临床研究实力。例如由田纳西州立大学MMC领导的研究 和范德比尔特-英格拉姆癌症中心(VICC)的调查人员与全州癌症登记机构合作，招募 对于乳腺癌的病因学研究，肺癌筛查试验以早期发现，烟草控制试验 服务不足，促进参与者招募到癌症研究和收集生物样本 与癌症外展核心和翻译病理学共享资源核心的合作。有一个 与临床试验办公室(CTO)之间的互动进行治疗性临床试验的丰富历史，网址为 VICC和NGH的首席技术官。实践共享资源核心的首要使命是增强 增加治疗性临床试验的收益，同时扩大少数族裔和服务不足的患者进行研究的机会 在整个癌症护理连续体中的研究。Practice Core与医学博士Lucy Spalluto进行了广泛的合作 在她提出的研究乳腺癌风险评估实施情况的项目的由来中 服务不足的女性。我们将协助这项研究的实施和成果的传播。我们的核心 还将支持癌症护理连续体系中的其他临床和基于人群的科学研究， 以减少癌症健康差距为重点的三个主题领域说明：预防和早期 检测；治疗期间和治疗后的介入试验和观察性研究；实施 医疗干预措施，以改善癌症护理的提供。实践核心将解决以下目标： 1)扩大与患者基础相关的治疗临床试验和癌症控制研究的组合 在Meharry和纳什维尔MSA；2)在Meharry的NGH开发一个癌症队列，作为资源 为未来的癌症护理连续体研究；以及3)为临床实习生提供培训和指导 在进行临床试验以及招募和留住研究中未得到充分服务的人群方面。