Core 1: PRACTICE Shared Resource Core

项目摘要：实践共享资源核心 癌症公平性人口研究和临床试验（PRACTICE）共享资源核心 将建立在现有的临床试验核心（CTC）的基础设施上，该基础设施为 Meharry/Vanderbilt-Ingram癌症中心/田纳西州癌症合作伙伴关系（MVTCP） 植入虽然CTC在将临床试验带到纳什维尔的患者基地方面发挥了重要作用 Meharry医学院（MMC）的综合医院（NGH），以更全面地解决癌症健康问题 差距，我们必须加强这些努力，在预防，早期发现，治疗， 生存和姑息治疗在纳什维尔大都会统计区（MSA），由我们的服务 伙伴关系我们建议建立PRACTICE共享资源核心，以进一步造福NGH 患者基础，促进医疗机构发起的研究，并将伙伴关系的覆盖范围扩大到服务不足的人群 在纳什维尔的MSA MVTCP在人口科学研究方面具有很大的优势，这将提高人口科学研究的效率。 现有临床研究实力。例如，田纳西州立大学MMC领导的研究 范德比尔特-英格拉姆癌症中心（VICC）的研究人员与全州癌症登记处合作， 乳腺癌的病因学研究，肺癌早期检测的筛查试验， 服务不足，加强参与者招募癌症研究和收集生物标本， 与癌症外展核心和转化病理学共享资源核心的合作。有一个 在开展治疗性临床试验方面有着丰富的历史， VICC和NGH的CTO。PRACTICE共享资源核心的首要使命是增强 增加治疗性临床试验的费用，同时扩大少数群体和服务不足的患者参与研究的机会 癌症护理连续体的研究。PRACTICE Core与医学博士Lucy Spalluto广泛合作 在她提出的研究乳腺癌风险评估的实施项目的起源， 服务不足的女性我们将协助开展这项研究并传播研究结果。我们的核心 还将支持癌症护理连续体中的其他临床和基于人群的科学研究， 在三个主题领域中说明，重点是减少癌症健康差距：预防和早期 检测;治疗期间和治疗后的干预性试验和观察性研究; 医疗保健干预，以改善癌症护理提供。“实践核心”将实现以下目标： 1)扩大与患者基础相关的治疗性临床试验和癌症控制研究组合， 梅哈里NGH和纳什维尔MSA; 2）在梅哈里NGH建立癌症队列，作为资源 3）为临床学员提供培训和导师服务 在开展临床试验以及在招募和留住研究中得不到充分服务的人群方面。

PROJECT SUMMARY: PRACTICE SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, we must augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. We propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum, illustrated in three thematic domains focused on decreasing cancer health disparities: prevention and early detection; interventional trials and observational studies during and following treatment; implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Core will address the following aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.