Molecular Imaging Specilized Resource

分子成像专业资源

• 批准号: 8541716
• 负责人: DAVID STOUT
• 金额: $ 14.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8541716
• 关键词: Animal Model; Animals; Authorization documentation; Autoradiography; Cancer Biology; Consultations; Cyclotrons; Data Analyses; Data Base Management; Data Quality; Databases; Department of Energy; Development; Educational process of instructing; Ensure; Equipment; Equipment and Supplies; Funding; Future; Goals; Hour; Human Resources; Image; Image Analysis; Imaging Device; Imaging Techniques; Imaging technology; Information Systems; Investigation; Link; Measurement; Metabolic; Monitor; Online Systems; Optics; Positron-Emission Tomography; Production; Protocols documentation; Radiation; Radiochemistry; Readiness; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rodent; Schedule; Scheduling and Staffing; Services; Side; System; Techniques; Time; Training; Training Support; Update; Work; cryostat; design; experience; imaging probe; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; instrumentation; meetings; molecular imaging; optical imaging; programs; prototype; research study; tool; user-friendly; web site

Introduction: The Molecular Imaging Specialized Resource supports in-vivo microPET, microCT, optical bioluminescent and fluorescent imaging and ex-vivo autoradiography for ICMIC research. The MISR was started as a Department of Energy facility in 1990 with a dedicated animal PET system. In 1997, microPET was developed at UCLA and the prototype system was used for rodent imaging until 2003. Over time, we added a microCT system in 1999 and upgraded it in 2003, added commercial microPET systems (P4: 2000-2007, Focus 220: 2003, Inveon DPET: 2008), optical imaging systems (3 IVIS 100 systems and a CRi Maestro), along with autoradiography and cryostat systems. We constantly evaluate new imaging technology and update systems when there is value and need for improved imaging devices. Since its inception in 1997, we have conducted over 26,000 microPET imaging experiments. Since previous ICMIC cycle began in 2005, the center has averaged just over 12,000 imaging studies of various types each year, roughly one thousand studies per month. The Molecular Imaging Shared Resource is essential for all four of the proposed ICMIC research projects and all four of the developmental fund projects, as well as future projects that require monitoring in-vivo measurements of metabolic function. All PET, CT, optical and autoradiography described in this proposal will make use of the MISR, making this resource central to the entire ICMIC program. The resource is intertwined with the production of imaging probes produced by the Cyclotron and Radiochemistry Specialized Resource directed by Dr. Satyamurthy and with the Quantitative Image Analysis Specialized Resource (QIASR) directed by Dr. Huang, which provides data analysis services to our investigators. The QIASR is especially linked with the MISR, since there is shared responsibility for managing the images and associated database information, image archival and website support of reports and usage information. Dr. Stout, who manages the MISR imaging facility, has worked closely with Drs. Huang and Satyamuthy for over 20 years and meets frequently with both to share information and maintain close coordination of efforts.

简介：分子成像专业资源支持体内microPET，microCT， 用于ICMIC研究的光学生物发光和荧光成像以及离体放射自显影。的 MISR于1990年作为能源部的一个设施开始使用专用的动物PET系统。在 1997年，microPET在UCLA开发，原型系统用于啮齿动物成像，直到 2003.随着时间的推移，我们在1999年增加了一个microCT系统，并在2003年对其进行了升级， microPET系统（P4：2000-2007，Focus 220：2003，Inveon DPET：2008），光学成像系统（3个IVIS 100系统和一个CRi Maestro），沿着放射自显影和低温恒温器系统。我们不断评估新的成像技术，并在有价值和需要改进成像设备时更新系统。自1997年成立以来，我们已经进行了超过26，000次microPET成像实验。 自2005年ICMIC周期开始以来，该中心平均每年进行12，000多项各种类型的成像研究，每月约1000项研究。 分子影像共享资源对所有四项ICMIC研究都至关重要 项目和所有四个发展基金项目，以及未来需要监测体内代谢功能测量的项目。本提案中描述的所有PET、CT、光学和放射自显影都将利用MISR，使该资源成为整个ICMIC计划的核心。该资源与Satyamurthy博士指导的回旋加速器和放射化学专业资源生产的成像探针以及Huang博士指导的定量图像分析专业资源（QIASR）交织在一起，后者为我们的研究人员提供数据分析服务。QIASR与MISR特别相关，因为双方共同负责管理图像和相关数据库信息、图像存档以及报告和使用信息的网站支持。管理MISR成像设施的Stout博士与Huang博士和Satyamuthy博士密切合作了20多年，并经常与他们会面，分享信息并保持密切的工作协调。