Molecular Imaging Specilized Resource

简介：分子成像专业资源支持体内microPET、microCT、 用于ICMIC研究的光学生物发光和荧光成像以及体外放射自显影。这个 MISR成立于1990年，是能源部的一个设施，拥有专门的动物PET系统。在……里面 1997年，加州大学洛杉矶分校开发了microPET，并将原型系统用于啮齿动物成像，直到 2003年。随着时间的推移，我们在1999年增加了一个微型CT系统，并在2003年对其进行了升级，增加了商业 MicroPET系统(P4：2000-2007，Focus 220：2003，Inveon DPET：2008)，光学成像系统(3个IVIS 100系统和1个CRI Maestro)，以及放射自显影和低温恒温器系统。我们不断评估新的成像技术，并在有价值和需要改进成像设备时更新系统。自1997年成立以来，我们已经进行了超过26,000个微型PET成像实验。 自2005年上一个ICMIC周期开始以来，该中心平均每年进行略高于12000项各种类型的成像研究，大约每月1000项研究。 分子成像共享资源对所有四个拟议的ICMIC研究都是必不可少的 项目和所有四个发展基金项目，以及需要监测体内代谢功能的未来项目。本提案中描述的所有PET、CT、光学和放射自显影技术都将使用MISR，使这一资源成为整个ICMIC计划的核心。该资源与由Satyamurthy博士指导的回旋加速器和放射化学专业资源生产的成像探针以及由黄博士指导的定量图像分析专业资源(QIASR)交织在一起，后者为我们的研究人员提供数据分析服务。QIASR特别与MISR联系在一起，因为它们共同负责管理图像和相关的数据库信息、图像存档以及报告和使用信息的网站支持。管理MISR成像设备的Stout博士与黄博士和Satyamuthy博士密切合作了20多年，并经常与他们会面，以共享信息并保持密切的工作协调。

Introduction: The Molecular Imaging Specialized Resource supports in-vivo microPET, microCT, optical bioluminescent and fluorescent imaging and ex-vivo autoradiography for ICMIC research. The MISR was started as a Department of Energy facility in 1990 with a dedicated animal PET system. In 1997, microPET was developed at UCLA and the prototype system was used for rodent imaging until 2003. Over time, we added a microCT system in 1999 and upgraded it in 2003, added commercial microPET systems (P4: 2000-2007, Focus 220: 2003, Inveon DPET: 2008), optical imaging systems (3 IVIS 100 systems and a CRi Maestro), along with autoradiography and cryostat systems. We constantly evaluate new imaging technology and update systems when there is value and need for improved imaging devices. Since its inception in 1997, we have conducted over 26,000 microPET imaging experiments. Since previous ICMIC cycle began in 2005, the center has averaged just over 12,000 imaging studies of various types each year, roughly one thousand studies per month. The Molecular Imaging Shared Resource is essential for all four of the proposed ICMIC research projects and all four of the developmental fund projects, as well as future projects that require monitoring in-vivo measurements of metabolic function. All PET, CT, optical and autoradiography described in this proposal will make use of the MISR, making this resource central to the entire ICMIC program. The resource is intertwined with the production of imaging probes produced by the Cyclotron and Radiochemistry Specialized Resource directed by Dr. Satyamurthy and with the Quantitative Image Analysis Specialized Resource (QIASR) directed by Dr. Huang, which provides data analysis services to our investigators. The QIASR is especially linked with the MISR, since there is shared responsibility for managing the images and associated database information, image archival and website support of reports and usage information. Dr. Stout, who manages the MISR imaging facility, has worked closely with Drs. Huang and Satyamuthy for over 20 years and meets frequently with both to share information and maintain close coordination of efforts.