Core--Molecular imaging facility
核心——分子成像设备
基本信息
- 批准号:7416822
- 负责人:
- 金额:$ 15.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Animal ExperimentationAnimal ModelAnimalsAutoradiographyAwardCenter Core GrantsCommunitiesComprehensive Cancer CenterConsultationsCyclotronsDataData AnalysesData Storage and RetrievalDepartment of EnergyDevelopmentEducational process of instructingEnsureEquipmentFutureGoalsGrantHourHuman ResourcesImageImaging DeviceImaging TechniquesImaging technologyInvestigationLinkModalityMusNumbersOnline SystemsOperative Surgical ProceduresOpticsPositron-Emission TomographyPrincipal InvestigatorProceduresProcessProtocols documentationPurposeRadiochemistryRadioisotopesRattusReproduction sporesResearchResearch PersonnelResourcesRestRetrievalScheduleScheduling and StaffingSideSterol O-AcyltransferaseSystemTechniquesTrainingUpdateWorkbasecareerdaydesigndigitalexperiencein vivo Cellular and Molecular Imaging Centersinstrumentinstrumentationmicrosystemsmolecular imagingoptical imagingprogramsresearch and developmentresearch studytechnology/techniquetooluser-friendly
项目摘要
D.2.1. Introduction: The purpose of the Molecular Imaging Specialized Resource is to support the
microPET, microCAT, optical and digital whole body autoradiography (DWBA) imaging requirements for the proposed ICMIC research and for additional molecular imaging projects across the rest of the UCLA biomedical community. The Molecular Imaging Specialized Resource receives support from the Department of Energy, the UCLA Jonsson Comprehensive Cancer Center Core Grant, several SPORE grants and several specialized research awards, in addition to the ICMIC. The Imaging Resource was started in 1990 as a DoE facility, with a dedicated animal research tomograph (Siemens, ACAT). We have constantly updated the imaging equipment with the newest and latest imaging technology and techniques. In 1997, the first dedicated small animal microPET system was put into routine use, followed by commercial versions from Concorde Microsystems, the P4 microPET in 1999 and the Focus microPET in 2003. As demand grew, we added a whole body digital autoradiography system (WBDA), a microCAT instrument and three optical imaging systems; two of which have both
bioluminescent and fluorescent optical imaging capabilities. Since inception, over 13,000 microPET imaging experiments have been successfully conducted. In 2003, the combined number of optical, microPET, microCAT and WBDA procedures exceeded 8000 experiments.
The Molecular Imaging Specialized Resource is essential for the work proposed in all four Research Components (Projects C.1-C.4), for the developmental projects of Drs. Huang and Sun (D.1 & D.2) that will extend into the next grant cycle, for future developmental projects and for career development research components. All of the projects will utilize the optical and/or microPET imaging systems for mouse and rat related research, making this resource essential and central for the entire ICMIC and for the research contained within this application. Image and data analysis will be handled by the Quantitative Analysis Specialized Resource (specialized resource 3), described in section D.3. However, all our Specialized Facilities are closely intertwined (radioisotopes prepared in the Cyclotron and Radiochemistry Specialized Resource are used for experimental studies in the Molecular Imaging Specialized Resource, and the data storage, interpretation and retrieval are facilitated by the Quantitative Analysis Specialized Resource.) The Molecular Imaging and the Quantitative Analysis facilities are highly inter-linked in their day-to-day activities to ensure that data are collected, processed and interpreted appropriately. The following table summarizes the projected needs of each ICMIC project for optical, PET, CT, optical and DWBA imaging, based on the applications found in this application and on information submitted by the principal investigators. As new developmental projects
and career development researchers enter the ICMIC program, their needs will be incorporated into the operations of the facility. The goals of the Molecular Imaging Specialized Resource, in conjunction with the Quantitative Analysis Specialized Resource, are (i) to develop a fully integrated process for creating animal imaging protocols, (ii) to assist investigators in obtaining the necessary approvals for research and (iii) to produce high quality, quantitative and reproducible molecular images using both single imaging systems and combinations of imaging modalities. These goals also include developing and maintaining techniques and equipment to ensure standardized imaging and optimal data analysis. We have found that providing investigators with transparent, common tools and techniques, along with teaching the use
and purposes behind these tools to new investigators, produces the most efficient use of the facility. We place special emphasis on training new investigators to become knowledgeable about molecular imaging tools and principles, so they can become capable researchers who can intelligently use the imaging techniques for both routine and new investigations. This aim is greatly aided by the synergy that comes from bringing together different investigators from different fields and backgrounds to work side-by-side in the shared imaging facility to conduct their research. Every effort in design of the work space, staffing, scheduled educational training periods, consultation practices and web-based scheduling and information accessibility is made to be user friendly; a place where both the experienced and new investigator can come and have easy access to the tools and techniques needed to complete their project. The facility is also staffed 12+ hours per day with helpful and knowledgeable personnel. At present, our support staff has a minimum of 13 years experience working with animal models and PET imaging and three years of experience with optical imaging and microCT studies. We
are proud of the fact that no experiment has gone undone during the course of the current ICMIC
because instrumentation, expertise or consultations were unavailable to an investigator.
D.2.1.简介:分子成像专业资源的目的是支持
microPET、microCAT、光学和数字全身放射自显影(DWBA)成像要求,用于拟议的ICMIC研究和加州大学洛杉矶分校生物医学界其他地区的其他分子成像项目。分子成像专业资源得到能源部,加州大学洛杉矶分校琼森综合癌症中心核心补助金,几个孢子赠款和几个专门的研究奖,除了ICMIC的支持。Imaging Resource于1990年开始作为DoE设施,拥有专用的动物研究断层扫描仪(Siemens,ACAT)。我们不断更新的成像设备与最新的成像技术和技术。1997年,第一个专用的小动物microPET系统投入常规使用,随后是Concorde Microsystems的商业版本,1999年的P4 microPET和2003年的Focus microPET。随着需求的增长,我们增加了一个全身数字放射自显影系统(WBDA),一个microCAT仪器和三个光学成像系统;其中两个系统同时具有
生物发光和荧光光学成像能力。自成立以来,已成功进行了超过13,000次microPET成像实验。2003年,光学、microPET、microCAT和WBDA程序的总数超过8000次。
分子成像专业资源对于所有四个研究部分(项目C.1-C.4)中提出的工作,对于黄博士和孙博士(D.1和D.2)的发展项目(将延伸到下一个资助周期),对于未来的发展项目和职业发展研究部分至关重要。所有项目都将利用光学和/或microPET成像系统进行小鼠和大鼠相关研究,使这一资源成为整个ICMIC和本应用程序中包含的研究的关键和核心。图像和数据分析将由定量分析专业资源(专业资源3)处理,如第D.3节所述。然而,我们所有的专业设施都是紧密交织在一起的(在回旋加速器和放射化学专业资源中制备的放射性同位素用于分子成像专业资源中的实验研究,并且通过定量分析专业资源促进数据存储,解释和检索。分子成像和定量分析设施在其日常活动中高度相互关联,以确保数据得到适当的收集,处理和解释。下表根据本申请中的申请和主要研究者提交的信息,总结了每个ICMIC项目对光学、PET、CT、光学和DWBA成像的预计需求。作为新的发展项目,
和职业发展研究人员进入ICMIC计划,他们的需求将被纳入该设施的运作。分子成像专业资源与定量分析专业资源相结合的目标是:(i)开发一个完全集成的过程来创建动物成像协议,(ii)协助研究人员获得必要的研究批准,以及(iii)使用单一成像系统和成像方式组合生成高质量、定量和可重复的分子图像。这些目标还包括开发和维护技术和设备,以确保标准化成像和最佳数据分析。我们发现,为调查人员提供透明、通用的工具和技术,沿着教授使用
以及这些工具背后的目的,以新的调查人员,产生最有效的利用设施。我们特别重视培训新的研究人员,使他们了解分子成像工具和原理,因此他们可以成为能够智能地将成像技术用于常规和新研究的有能力的研究人员。这一目标在很大程度上得益于来自不同领域和背景的不同研究人员在共享成像设施中并肩工作以进行研究的协同作用。在设计工作空间、人员配备、预定的教育培训期、咨询做法和基于网络的时间安排以及信息可访问性方面所做的每一项努力都是用户友好的;一个有经验的和新的调查员都可以来的地方,并可以轻松获得完成项目所需的工具和技术。该设施每天工作12小时以上,有乐于助人和知识渊博的工作人员。目前,我们的支持人员至少有13年的动物模型和PET成像工作经验,以及3年的光学成像和microCT研究经验。我们
我们感到自豪的是,在目前的ICMIC过程中,
因为研究者无法获得仪器、专业知识或咨询。
项目成果
期刊论文数量(0)
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