Molecular Imaging Specilized Resource

分子成像专业资源

• 批准号: 8330934
• 负责人: DAVID STOUT
• 金额: $ 7.54万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8330934
• 关键词: Animal Model; Animals; Authorization documentation; Autoradiography; Cancer Biology; Consultations; Cyclotrons; Data Analyses; Data Base Management; Data Quality; Databases; Department of Energy; Development; Educational process of instructing; Ensure; Equipment; Equipment and Supplies; Funding; Future; Goals; Hour; Human Resources; Image; Image Analysis; Imaging Device; Imaging Techniques; Imaging technology; Information Systems; Investigation; Link; Measurement; Metabolic; Monitor; Online Systems; Optics; Positron-Emission Tomography; Production; Protocols documentation; Radiation; Radiochemistry; Readiness; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rodent; Schedule; Scheduling and Staffing; Services; Side; System; Techniques; Time; Training; Training Support; Update; Work; cryostat; design; experience; imaging probe; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; instrumentation; meetings; molecular imaging; optical imaging; programs; prototype; research study; tool; user-friendly; web site

Introduction: The Molecular Imaging Specialized Resource supports in-vivo microPET, microCT, optical bioluminescent and fluorescent imaging and ex-vivo autoradiography for ICMIC research. The MISR was started as a Department of Energy facility in 1990 with a dedicated animal PET system. In 1997, microPET was developed at UCLA and the prototype system was used for rodent imaging until 2003. Over time, we added a microCT system in 1999 and upgraded it in 2003, added commercial microPET systems (P4: 2000-2007, Focus 220: 2003, Inveon DPET: 2008), optical imaging systems (3 IVIS 100 systems and a CRi Maestro), along with autoradiography and cryostat systems. We constantly evaluate new imaging technology and update systems when there is value and need for improved imaging devices. Since its inception in 1997, we have conducted over 26,000 microPET imaging experiments. Since previous ICMIC cycle began in 2005, the center has averaged just over 12,000 imaging studies of various types each year, roughly one thousand studies per month. The Molecular Imaging Shared Resource is essential for all four of the proposed ICMIC research projects and all four of the developmental fund projects, as well as future projects that require monitoring in-vivo measurements of metabolic function. All PET, CT, optical and autoradiography described in this proposal will make use of the MISR, making this resource central to the entire ICMIC program. The resource is intertwined with the production of imaging probes produced by the Cyclotron and Radiochemistry Specialized Resource directed by Dr. Satyamurthy and with the Quantitative Image Analysis Specialized Resource (QIASR) directed by Dr. Huang, which provides data analysis services to our investigators. The QIASR is especially linked with the MISR, since there is shared responsibility for managing the images and associated database information, image archival and website support of reports and usage information. Dr. Stout, who manages the MISR imaging facility, has worked closely with Drs. Huang and Satyamuthy for over 20 years and meets frequently with both to share information and maintain close coordination of efforts.

简介：分子成像专业资源支持体内 microPET、microCT、 用于 ICMIC 研究的光学生物发光和荧光成像以及体外放射自显影。这 MISR 成立于 1990 年，最初是能源部的一个设施，拥有专用的动物 PET 系统。在 1997 年，加州大学洛杉矶分校 (UCLA) 开发了 microPET，原型系统用于啮齿动物成像，直到 2003年。随着时间的推移，我们在1999年增加了microCT系统，并在2003年对其进行了升级，增加了商业 microPET 系统（P4：2000-2007、Focus 220：2003、Inveon DPET：2008）、光学成像系统（3 个 IVIS 100 系统和一个 CRi Maestro）以及放射自显影和低温恒温器系统。当改进成像设备有价值且需要改进时，我们不断评估新的成像技术并更新系统。自 1997 年成立以来，我们已进行了 26,000 多次 microPET 成像实验。 自 2005 年开始上一届 ICMIC 周期以来，该中心每年平均进行超过 12,000 项各种类型的影像研究，每月大约进行 1000 项研究。 分子成像共享资源对于所有四项拟议的 ICMIC 研究至关重要 项目和所有四个发展基金项目，以及需要监测代谢功能体内测量的未来项目。本提案中描述的所有 PET、CT、光学和放射自显影都将利用 MISR，使该资源成为整个 ICMIC 计划的核心。该资源与 Satyamurthy 博士指导的回旋加速器和放射化学专业资源生产的成像探针的生产以及黄博士指导的定量图像分析专业资源 (QIASR) 交织在一起，后者为我们的研究人员提供数据分析服务。 QIASR 与 MISR 特别相关，因为它们共同负责管理图像和相关数据库信息、图像存档以及报告和使用信息的网站支持。 Stout 博士负责管理 MISR 成像设施，与 Drs. 密切合作。 Huang 和 Satyamuthy 已合作 20 多年，并经常与两人会面，分享信息并保持密切协调。