Inheritance of DNA methylation state in humans

人类DNA甲基化状态的遗传

• 批准号: nhmrc : 1010374
• 负责人: Dr Allan Mcrae
• 金额: $ 48.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inheritance-dna-methylation-state-humans/109485
• 关键词: Inheritance; DNA; methylation; state; humans

In the study of common disease, it is becoming apparent that it is not only an individual's DNA sequence that can encode susceptibility to disease, but also chemical modifications to that sequence. Despite the importance of these chemical modifications in the development of disease, there has been no comprehensive survey of the extent which they are transmitted across generations in humans. This proposal will investigate how one of those modifications, DNA methylation, is inherited.

在常见疾病的研究中，越来越明显的是，不仅个体的 DNA 序列可以编码对疾病的易感性，而且还可以对该序列进行化学修饰。尽管这些化学修饰在疾病发展中很重要，但尚未对它们在人类中代际传播的程度进行全面调查。该提案将研究其中一种修饰（DNA 甲基化）是如何遗传的。