Administrative and Biostatistics Core

行政和生物统计核心

• 批准号: 8492617
• 负责人: TODD M ALLEN
• 金额: $ 17.01万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-07 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8492617
• 关键词: B-Lymphocytes; Biostatistics Core; Bone Marrow; CD8B1 gene; Clinical; Core Facility; Data; Databases; Development; Ensure; Goals; Grant; HIV; HIV Infections; Human; Immune; Immune response; Immunologics; Individual; Instruction; Leadership; Liver; Maintenance; Modeling; Mus; Process; Program Research Project Grants; Records; Recruitment Activity; Research; Research Personnel; Retrieval; Sampling; System; T cell response; T-Lymphocyte; Testing; Thymus Gland; Translating; Vaccinated; Vaccine Design; Vaccines; meetings; mouse model; nanoparticle; neutralizing antibody; novel; programs; response; success

This Program Project Grant (PPG) builds on the investigators strong track records in understanding neutralizing antibody and CD8+ T cell responses against HIV, the development of novel nanoparticle delivery appraoches and translates these efforts into a newly developed BLT (bone marrow, liver, thymus) humanized mouse model of HIV infection. Critical to the success of this POl is an Administrative and Biostatistics Core facility provide not only scientific and administrative leadership in coordinating the two Projects and three Cores that make up this effort, but also to coordinate the acquisition, storage, and retrieval of samples from vaccinated and challenged humanized mice for each of the individual projects that fuel the research, to insure quality processing and storage of these valuable samples, to maintain a database to support the goals of this program, and to provide biostatistical support that will allow integration of clinical, immunologic and virologic data for the highly complementary projects that make up this POl. These efforts will occur in parallel, but in a coordinated and highly integrated fashion that allows for information from each of the efforts to continually guide and inform the others. Specifically, we propose that the Administrative and Biostatistics Core will: 1. Provide scientific leadership and project management for all aspects of the grant. 2. Provide administrative and financial oversight. 3. Provide biostatistical support for all aspects of the program. 4. Recruit a Scientific Advisory Board and host an annual meeting. 5. Maintain a database of clinical, immunological, and virological data from BLT mice.

该计划项目赠款（PPG）在调查人员的基础上建立在理解方面的强大记录 对HIV的中和抗体和CD8+ T细胞反应，新型纳米粒子递送的发展 评估并将这些努力转化为新开发的BLT（骨髓，肝，胸腺） hiv感染的人源化小鼠模型。对此POL的成功至关重要的是行政管理 生物统计学核心设施不仅提供了协调两者的科学和行政领导 构成这项工作的项目和三个核心，也要协调收购，存储和 从接种疫苗和挑战的人源化小鼠中检索样品，以供每个单个项目 为研究提供助长研究，以确保这些有价值的样本的质量处理和存储，以维持 数据库支持该计划的目标，并提供生物统计支持，以允许集成 构成该POL的高度互补项目的临床，免疫和病毒数据。 这些努力将同时进行，但以协调和高度综合的方式进行 来自每项努力的信息，以不断指导和通知其他努力。具体来说，我们建议 行政和生物统计学核心将： 1。为赠款的各个方面提供科学领导和项目管理。 2。提供行政和财务监督。 3。为程序的各个方面提供生物统计支持。 4.招募科学顾问委员会并举行年度会议。 5。维护BLT小鼠的临床，免疫学和病毒学数据数据库。