Administrative and Biostatistics Core

行政和生物统计核心

• 批准号: 8492617
• 负责人: TODD M ALLEN
• 金额: $ 17.01万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-07 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8492617
• 关键词: B-Lymphocytes; Biostatistics Core; Bone Marrow; CD8B1 gene; Clinical; Core Facility; Data; Databases; Development; Ensure; Goals; Grant; HIV; HIV Infections; Human; Immune; Immune response; Immunologics; Individual; Instruction; Leadership; Liver; Maintenance; Modeling; Mus; Process; Program Research Project Grants; Records; Recruitment Activity; Research; Research Personnel; Retrieval; Sampling; System; T cell response; T-Lymphocyte; Testing; Thymus Gland; Translating; Vaccinated; Vaccine Design; Vaccines; meetings; mouse model; nanoparticle; neutralizing antibody; novel; programs; response; success

This Program Project Grant (PPG) builds on the investigators strong track records in understanding neutralizing antibody and CD8+ T cell responses against HIV, the development of novel nanoparticle delivery appraoches and translates these efforts into a newly developed BLT (bone marrow, liver, thymus) humanized mouse model of HIV infection. Critical to the success of this POl is an Administrative and Biostatistics Core facility provide not only scientific and administrative leadership in coordinating the two Projects and three Cores that make up this effort, but also to coordinate the acquisition, storage, and retrieval of samples from vaccinated and challenged humanized mice for each of the individual projects that fuel the research, to insure quality processing and storage of these valuable samples, to maintain a database to support the goals of this program, and to provide biostatistical support that will allow integration of clinical, immunologic and virologic data for the highly complementary projects that make up this POl. These efforts will occur in parallel, but in a coordinated and highly integrated fashion that allows for information from each of the efforts to continually guide and inform the others. Specifically, we propose that the Administrative and Biostatistics Core will: 1. Provide scientific leadership and project management for all aspects of the grant. 2. Provide administrative and financial oversight. 3. Provide biostatistical support for all aspects of the program. 4. Recruit a Scientific Advisory Board and host an annual meeting. 5. Maintain a database of clinical, immunological, and virological data from BLT mice.

该计划项目补助金（PPG）建立在研究人员在理解方面的良好记录基础上 针对HIV的中和抗体和CD8+ T细胞应答，开发新型纳米颗粒递送 评估并将这些努力转化为新开发的BLT（骨髓，肝脏，胸腺） HIV感染的人源化小鼠模型。这一政策目标的成功关键是一个行政和 生物统计核心设施不仅提供科学和行政领导， 项目和三个核心，使这一努力，而且还协调收购，储存， 从接种疫苗和激发的人源化小鼠中检索样品，用于每个单独的项目， 为研究提供燃料，确保这些宝贵样品的高质量处理和储存， 数据库，以支持本计划的目标，并提供生物统计支持，将允许整合 临床，免疫学和病毒学数据的高度互补的项目，使这一政策。 这些努力将并行进行，但以协调和高度一体化的方式进行， 从每一个努力的信息，以不断指导和通知他人。具体而言，我们建议， 行政和生物统计核心将： 1.为赠款的各个方面提供科学的领导和项目管理。 2.提供行政和财务监督。 3.为项目的各个方面提供生物统计支持。 4.招募一个科学顾问委员会，并举办年度会议。 5.维护BLT小鼠的临床、免疫学和病毒学数据的数据库。