Molecular Basis of Infectious Diseases

描述（由申请人提供）：传染病分子基础（MBID）研究培训计划以来自休斯顿三所教育机构的16名教师导师为中心：德克萨斯大学，休斯顿德克萨斯健康科学中心，贝勒医学院和德克萨斯A&M大学生物科学与技术研究所。在这份续签申请中，我们要求为3名博士生和8名本科生暑期研究生提供继续培训支持。MBID培训计划的总体目的是为学员提供1)在微生物研究的最新概念和技术方面培养新科学家的最佳环境；2)更好地了解当前临床传染病面临的挑战；3)在基础研究和临床应用之间“弥合差距”的知识和工具。这项培训赠款的基础是传染病分子基础小组，该小组于1996年首次成立。MBID已经发展成为一个高度互动的团队，有400多名教师、博士后、研究生和来自休斯顿地区的工作人员，他们的主要兴趣是细菌感染的分子发病机制。16名教师组成了这项培训基金的核心，他们有着很高的研究效率和广泛的合作记录。近十年来，共培养博士、博士后178人，博士生22人，博士后25人。培训计划基于强大的核心课程，密集和互动的研究经验，每月MBID会议，年度务静会，每周研讨会和期刊俱乐部，以及转化研究和临床传染病培训。已经建立了一个夏季研究项目，以帮助招募有前途的本科生（特别是代表性不足的少数民族[URM]实习生）从事传染病研究工作。在最初的资助期间，7名博士预科学员中有3名和31名暑期本科生学员中有10名是URM的学生，因此有望在即将到来的资助期间继续成功实现这一目标。

DESCRIPTION (provided by applicant): The Molecular Basis of Infectious Disease (MBID) research training program is centered on 16 faculty mentors from three Houston educational institutions: the University, of Texas Health Science Center at Houston, Baylor College of Medicine, and the Texas A&M University Institute for Biosciences and Technology. In this renewal application, continued training support is requested for three Ph.D. students and eight undergraduate summer research students. The overall purpose of the MBID training program is to provide trainees 1) an optimal environment for training new scientists in the latest concepts and techniques in microbiological research; 2) a better understanding of current challenges in clinical infectious diseases; and 3) the knowledge and tools to 'bridge the gap' between basic research and clinical applications. The basis of this training grant is the Molecular Basis of Infectious Disease group, which was first formed in 1996. MBID has developed into highly interactive group of over 400 faculty, postdoctoral fellows, graduate students, and staff from the Houston area whose primary interest is in the molecular pathogenesis of bacterial infections. The 16 faculty members that form the core of this training grant have a record of high research productivity and extensive collaborations. They have mentored 178 predoctoral and postdoctoral trainees during the past ten years, and currently are mentoring 22 Ph.D. students and 25 postdoctoral fellows. The training program is based on a strong core curriculum, intensive and interactive research experiences, monthly MBID meetings, annual retreats, weekly seminars and journal clubs, and training in translational research and clinical infectious diseases. A summer research program has been established to aid in the recruitment of promising undergraduate students (and in particular underrepresented minority [URM] trainees) into careers in infectious disease research. During the initial grant period, 3 of 7 predoctoral trainees and 10 of 31 summer undergraduate trainees were URM students, thus promising continued success in this objective during the coming grant period. RELEVANCE: The major goal of this ongoing, successful training grant is to provide microbiology trainees additional knowledge in clinical infectious diseases and translational research, thereby directing research toward the more rapid resolution of important infectious disease problems. In addition, the program will continue to recruit highly qualified underrepresented minority students, increasing the proportion of underrepresented minority scientists performing research at the cutting edge of the microbiology/infectious disease interface.