Genetic and physiological mechanisms of temperature detection and compensation

描述(申请人提供)：所有动物生活在不断变化的环境中，因此，受到温度等关键环境线索波动的影响。鉴于所有生化反应都对温度有一定程度的敏感，动物为了保持稳定的体内条件，对这些温度变化进行补偿尤为关键。为了做到这一点，动物必须能够检测到微小的温度变化，然后触发适当的动态平衡补偿机制。到目前为止，对温度检测和热传导的分子和神经元基础，以及温度适应和补偿的生理机制的研究，在很大程度上是作为独立的研究线进行的。为了充分了解动物如何对温度变化做出适当的反应，必须将这些智力问题放在一起，作为一个整体进行研究。在本计划项目拨款中，我们汇集了在温度检测和温度补偿问题上经验丰富的研究人员，询问动物如何检测温度变化，并将这些信息转化为神经元功能的补偿性变化，以保持行为的健壮性。这一建议的一个特别优点是在多个系统中探索这些问题的研究人员之间的协同作用；这种多样性将阐明可以在其他物种中推广的共同基本原则。这里提出的总体问题是： 1)动物探测温度变化的分子机制是什么？ 2)编码温度变化信息的神经机制是什么？ 3)运动程序如何补偿温度波动？ 4)是什么定义了这些动态平衡机制运行的范围限制？ 5)物种间温度检测和补偿的共同原则是什么？

DESCRIPTION (provided by applicant): All animals live in constantly changing environments and are, therefore, subjected to fluctuations in critical environmental cues such as temperature. Given that all biochemical reactions are temperature sensitive to a certain extent, it is particularly critical for animals to compensate for these temperature changes in order to maintain steady internal conditions. In order to do so, animals must be able to detect small temperature changes and then trigger the appropriate homeostatic compensatory mechanisms. To date, research into the molecular and neuronal basis of temperature detection and thermotransduction, and the physiological mechanisms of temperature adaptation and compensation, have largely been pursued as independent lines of investigation. To obtain a full understanding of how animals respond appropriately to temperature changes, these intellectual issues must be brought together and studied as a whole. In this Program Project grant we bring together researchers experienced in issues of temperature detection and temperature compensation to ask how animals detect temperature changes and translate this information to effect compensatory changes in neuron function to maintain behavioral robustness. A particular strength of this proposal is the synergy among investigators exploring these issues in multiple systems; this diversity will elucidate common underlying principles that can be generalized ID other species. The overall questions being asked here are: 1) What are the molecular mechanisms by which animals detect temperature changes? 2) What are the neuronal mechanisms that encode information about temperature changes? 3) How do motor programs compensate for temperature fluctuations? 4) What defines the limits of the range in which these homeostatic mechanisms operate? 5) What are the common principles of temperature detection and compensation among species?