Inhibition of endothelial cell adhesion molecule expression by high density lipoproteins

高密度脂蛋白抑制内皮细胞粘附分子表达

• 批准号: nhmrc : 207742
• 负责人: Paul Baker
• 金额: $ 5.37万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-endothelial-cell-density-lipoproteins/99705
• 关键词: Inhibition; endothelial; cell; adhesion; molecule

It is well known that high levels of cholesterol in blood cause coronary heart disease. However, it is also known that not all of the blood cholesterol is bad. If it is carried in particles called low density lipoproteins or LDLs it causes heart disease. But if it is carried in other particles known as high density lipoproteins or HDLs it does not. In fact, it is now well known that HDLs actually protect against the development of coronary heart disease. There are two main actions of HDLs that contribute to their ability to protect. Firstly, they are known to drain cholesterol out of coronary arteries. We have recently shown that they have a second action. The end result of this second action is a slowing down of the entry into coronary arteries of cells called monocytes that are necessary for the development of the atherosclerosis that causes the heart disease. This project is concerned with this ability of HDLs to slow down the development of atherosclerosis by the second action. We have found that this second action of HDLs is influenced by the type of fats they carry. We propose now to investigate the mechanism by which different fats influence this action of HDLs with a view to devising new strategies for the prevention of heart disease.

众所周知，血液中胆固醇含量过高会导致冠心病。然而，我们也知道，并非所有的血液胆固醇都是坏的。如果它携带在称为低密度脂蛋白或LDL的颗粒中，它会导致心脏病。但如果它是由其他颗粒携带的，称为高密度脂蛋白或HDL，它就不会。事实上，现在众所周知，HDL实际上可以防止冠心病的发展。HDL的两个主要作用有助于其保护能力。首先，众所周知，它们可以将胆固醇排出冠状动脉。我们最近证明了它们还有第二个作用。这第二个作用的最终结果是减缓了称为单核细胞的细胞进入冠状动脉的速度，单核细胞是导致心脏病的动脉粥样硬化发展所必需的。本项目关注HDL通过第二种作用减缓动脉粥样硬化发展的能力。我们发现HDL的第二种作用受到它们携带的脂肪类型的影响。我们现在建议研究不同脂肪影响HDL这种作用的机制，以期制定预防心脏病的新策略。