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Genetic Moderators of Divorce Adjustment: A Pilot Investigation

离婚调整的遗传调节因素：试点调查

基本信息

批准号：
8319366
负责人：
DAVID A SBARRA
金额：
$ 16.67万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-15 至 2015-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8319366
关键词：
Adult American Animals Applications Grants Area Behavior Behavioral Biological Blood Pressure C-reactive protein Candidate Disease Gene Cardiovascular system Caucasians Caucasoid Race Consensus DNA Data Data Analyses Divorce Emotional Emotions Environment European Event Exploratory/Developmental Grant Frequencies Genes Genetic Genetic Polymorphism Genetic Risk Genotype Goals Grant Health Heterogeneity Inflammation Institute of Medicine (U.S.)Interleukin-6 Investigation Laboratories Life Literature Major Depressive Disorder Marital separation Marriage Measurement Measures Mental Depression Mental Health Mental disorders Molecular Molecular Genetics Monoamine Oxidase A Moods Morbidity - disease rate NIH Program Announcements Nature Noise Outcome Participant Pathway interactions Pattern Persons Phenotype Pilot Projects Prevention program Probability Psychiatric Diagnosis Psychiatry Psychological Stress Psychology Psychosocial Assessment and Care Psychosomatic Medicine Public Health Recommendation Recovery Reporting Research Risk Role Sampling Sampling Studies Serotonin Serotonin Receptor 5-HT1A Serotonin Receptor 5-HT2A Severities Single Nucleotide Polymorphism Social Environment Stress Symptoms System Time Tumor Necrosis Factor-alpha Withdrawal Work Writing base coping cost effective cytokine design disturbance in affect divorce/separation environmental stressor experience genetic epidemiology improved insight interdisciplinary collaboration interest physical conditioning programs prospective psychologic psychosocial resilience response serotonin transporter simulation social stressor treatment program

项目摘要

DESCRIPTION (provided by applicant): The proposed research investigates the potential genetic moderators of psychological and physical adjustment to the common life stressor of divorce. Although most people are resilient in the face of divorce, a subset of adults becomes stuck on pathways toward maladaptive outcomes, making the association between divorce, mood disturbances, and physical health a significant public health concern. The primary goal of this project is to collect deoxyribonucleic acid (DNA) from 190 adults (156 of Caucasian/European American descent) who have experienced a recent marital separation in order to (1) investigate candidate polymorphisms in four serotonin genes that may interact with the psychosocial context of marital separation to moderate changes in mood symptoms over a 9-month period and (2) investigate the role of genes within the inflammation system that may moderate changes in blood pressure (BP) reactivity to a divorce-specific laboratory challenge paradigm. By studying the potential genetic moderators of divorce adjustment, this work can provide new insights into who fares well or poorly following the end of marriage. There is consensus in the fields of genetic epidemiology and molecular psychiatry that the study of genotypic effects on psychological and biological end- points of interest can be greatly enhanced through improved measurement of the psychosocial environment. Thus, by carefully measuring adults' psychological responses to their separation and degree of reported stress, this work has the potential to enhance what is known about the effects of gene-environment (G X E) interactions on psychological and health-related phenotypes of interest. The proposed research is one the first prospective investigations of how G X E interactions may limit or promote emotional and biological recovery over time. Using a planned missingness design (intended to decrease participant attrition), adults will be studied at four occasions over a 9-month period. Simulation studies of this sampling approach reveal that the proposed study will be adequately powered to detect small G X E interaction effects on changes in mood symptoms and BP reactivity. In combination, the study of genes in both the serotonin and inflammation systems, the detailed assessment of the psychosocial context of divorce, and the prospective sampling and data analyses will make the proposed study unique to the existing literature and one with potential for high scientific yield in an understudied area of public health significance. This research will contribute to the growing effort to identify the precise effect size estimates in G X E studies of mood disturbances, as well as newly emerging research in psychosomatic medicine that combines genes, psychological variables, and biological response patterns of interest. There are many reasons to believe that genes in the emotion and inflammation systems interact to produce both increased depression and heightened BP responses, and the proposed investigation has promise to make timely and important contributions to this growing area of research.

描述（由申请人提供）：拟议的研究调查了离婚常见生活压力的心理和身体调整的潜在遗传调节因子。虽然大多数人在离婚面前都很有弹性，但有一部分成年人却陷入了适应不良的境地，这使得离婚、情绪障碍和身体健康之间的联系成为一个重大的公共卫生问题。这个项目的首要目标是从190名成年人身上收集脱氧核糖核酸（DNA）（156名白人/欧洲裔美国人），他们最近经历了婚姻分离，目的是（1）调查四种5-羟色胺基因的候选多态性，这些基因可能与婚姻分离的心理社会背景相互作用，以缓解9个月内情绪症状的变化，以及（2）研究炎症系统中基因的作用，这些基因可能会缓和血压（BP）对离婚特异性实验室挑战范式的反应性变化。通过研究离婚调整的潜在遗传调节因素，这项工作可以为婚姻结束后谁的表现好或不好提供新的见解。遗传流行病学和分子精神病学领域的共识是，通过改进对心理社会环境的测量，可以大大加强对感兴趣的心理和生物终点的基因型影响的研究。因此，通过仔细测量成年人对他们的分离和报告的压力程度的心理反应，这项工作有可能增强基因-环境（G X E）相互作用对心理和健康相关表型的影响。这项研究是关于G X E相互作用如何随着时间的推移限制或促进情感和生物恢复的第一个前瞻性研究。使用计划缺失设计（旨在减少参与者流失），将在9个月内对成人进行4次研究。这种抽样方法的模拟研究表明，拟议的研究将有足够的动力来检测小G X E的相互作用对情绪症状和BP反应性的变化的影响。结合起来，对5-羟色胺和炎症系统中的基因的研究，对离婚的心理社会背景的详细评估，以及前瞻性的抽样和数据分析，将使拟议的研究成为现有文献中独一无二的，并且在一个未充分研究的公共卫生意义领域具有高科学产量的潜力。这项研究将有助于越来越多的努力，以确定精确的效果大小估计在G X E研究的情绪障碍，以及新兴的研究，在心身医学相结合的基因，心理变量和生物反应模式的兴趣。有很多理由相信，情绪和炎症系统中的基因相互作用，导致抑郁症增加和血压反应升高，拟议的调查有望为这一不断增长的研究领域做出及时和重要的贡献。