Genetically Informed Studies of Social Connectedness and Health

社会联系与健康的遗传学研究

基本信息

  • 批准号:
    10681448
  • 负责人:
  • 金额:
    $ 89.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-15 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

7. PROJECT SUMMARY A large body of evidence indicates that high-quality social relationships are correlated with decreased risk for morbidity and mortality from a range of disease outcomes, and that social disconnection and poor relationship quality are correlated with considerable risk for negative health outcomes. Although most of the work in this area is correlational in nature, it is often interpreted as if it is causal. Genetically informed research methods can allow researchers to rule-out causal explanations for epidemiological associations and/or identify effects that may be consistent with a causal influence. Using co-twin control methods and a comprehensive new data collection in the Washington State Twin Registry (WSTR), this grant brings together a diverse and established scientific team to examine a series of unanswered questions around social relationships, health, and cognitive functioning, all of which center on causal inference. The work in this proposal is guided by three Specific Aims that will: (1) Conduct a detailed assessment of social relationship functioning in the WSTR and use these variables in co-twin analyses of health and health behaviors. We will conduct a new data collection on 1,000 adult twin pairs (N = 2,000) in the WSTR and complete a “deep phenotyping” of key relationship quality variables, including social integration, relationship satisfaction/quality, and attachment styles. Under Aim 1, we will also collect DNA methylation data and use a series of epigenetic clocks to characterize accelerated biological aging among our main study outcomes; (2) Conduct a detailed neuropsychological assessment of cognitive functioning in the WSTR cohort and use these variables as key outcomes in co-twin models. Social isolation and loneliness may hasten declines in cognitive functioning, but are these associations consistent with a causal effect? We will conduct detailed neuropsychological assessments of the 2,000 WSTR participants using assessments that target cognitive outcomes shown to be associated with accelerated cognitive decline, mild cognitive impairment, and biomarkers of Alzheimer’s disease and related dementias; and (3) Examine the association between objective measures of daily social functioning and the health and cognitive outcomes in the WSTR. The Electronically Activated Recorder (EAR) is a smartphone application that records ambient sounds in participants’ daily lives and provides a means of assessing social behaviors beyond self-report alone. We will collect EAR data from a sub-sample of 140 adult MZ twin pairs discordant for marital status (N = 280) from the WSTR to determine if within twin-pair differences in the objective indices of social integration are associated with the health, health behavior, and cognitive outcomes. Successful completion of the proposed research will help build a causal foundation for public health intervention efforts around social relationships.
7. 项目总结

项目成果

期刊论文数量(0)
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专利数量(0)

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DAVID A SBARRA其他文献

DAVID A SBARRA的其他文献

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{{ truncateString('DAVID A SBARRA', 18)}}的其他基金

Genetically Informed Studies of Social Connectedness and Health
社会联系与健康的遗传学研究
  • 批准号:
    10503656
  • 财政年份:
    2022
  • 资助金额:
    $ 89.35万
  • 项目类别:
Genetic Moderators of Divorce Adjustment: A Pilot Investigation
离婚调整的遗传调节因素:试点调查
  • 批准号:
    8319366
  • 财政年份:
    2011
  • 资助金额:
    $ 89.35万
  • 项目类别:
Sleep and Divorce: Identifying Bidirectional Vulnerability and Resilience
睡眠与离婚:识别双向脆弱性和复原力
  • 批准号:
    8690616
  • 财政年份:
    2011
  • 资助金额:
    $ 89.35万
  • 项目类别:
Genetic Moderators of Divorce Adjustment: A Pilot Investigation
离婚调整的遗传调节因素:试点调查
  • 批准号:
    8045339
  • 财政年份:
    2011
  • 资助金额:
    $ 89.35万
  • 项目类别:
Case Simulation Methods for Teaching Empirically-Validated Behavioral Treatments
用于教学经经验验证的行为治疗的案例模拟方法
  • 批准号:
    8332323
  • 财政年份:
    2008
  • 资助金额:
    $ 89.35万
  • 项目类别:
Divorce in mid-life: Mechanisms of biopsychosocial adaptation over time
中年离婚:随着时间的推移生物心理社会适应机制
  • 批准号:
    7250812
  • 财政年份:
    2007
  • 资助金额:
    $ 89.35万
  • 项目类别:
Divorce in mid-life: Mechanisms of biopsychosocial adaptation over time
中年离婚:随着时间的推移生物心理社会适应机制
  • 批准号:
    7385933
  • 财政年份:
    2007
  • 资助金额:
    $ 89.35万
  • 项目类别:
Divorce, Depression, and Biobehavioral Dysregulation
离婚、抑郁和生物行为失调
  • 批准号:
    7243429
  • 财政年份:
    2006
  • 资助金额:
    $ 89.35万
  • 项目类别:
Divorce, Depression, and Biobehavioral Dysregulation
离婚、抑郁和生物行为失调
  • 批准号:
    7091712
  • 财政年份:
    2006
  • 资助金额:
    $ 89.35万
  • 项目类别:
AFFECTIVE PROCESSING FOLLOWING RELATIONSHIP DISSOLUTION
关系解除后的情感处理
  • 批准号:
    6528487
  • 财政年份:
    2002
  • 资助金额:
    $ 89.35万
  • 项目类别:

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