Heat shock protein 27 (HSP27) as a marker of atherosclerosis
热休克蛋白 27 (HSP27) 作为动脉粥样硬化的标志物
基本信息
- 批准号:8505535
- 负责人:
- 金额:$ 6.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-02-01 至 2017-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAfrican AmericanAgeAgingAnti-Inflammatory AgentsAnti-inflammatoryAntiatherogenicApoptoticArterial Fatty StreakAtherosclerosisBiochemicalBiochemical MarkersBiological AssayBiological MarkersBloodBlood ProteinsBlood VesselsBlood specimenCardiac Catheterization ProceduresCardiac DeathCardiologyCardiovascular DiseasesCardiovascular systemCarotid Atherosclerotic DiseaseCaucasiansCaucasoid RaceCellsClinicalClinical DataClinical ResearchCohort StudiesComorbidityComplexCoronaryCoronary arteryDropsEndothelial CellsEventFutureGoalsHSPB1 geneHealthHealth Services AccessibilityHealth systemHeat Shock Protein 27HospitalizationImmunoassayIndividualInstructionKineticsKnowledgeLeadMeasuresMedical StaffMethodsModelingMolecular ChaperonesMolecular Sieve ChromatographyMonitorMyocardial InfarctionOutcomeOutpatientsPatientsPhosphorylationPilot ProjectsPlasmaPopulationPredictive Value of TestsPregnancyPregnancy-Associated Plasma Protein-AProductionPrognostic MarkerProteinsRecoveryResearchRiskRisk AssessmentRoleSamplingSmooth Muscle MyocytesStress TestsStudy SubjectTestingTimeTissuesUnderserved Populationacute coronary syndromeartery occlusionbasecardiovascular risk factorcase controleffective therapyhigh riskmedically underservedmedically underserved populationminority healthmolecular sizepatient populationprotective effectprotein complexvolunteer
项目摘要
PROJECT SUMMARY (See instructions):
African-Americans die from atherosclerotic cardiovascular disease at a higher rate than Caucasians.
African-Americans present late and suffer from multiple co-morbidities. These factors all support the need for inexpensive, non-invasive outpatient methods to identify patients at risk for an acute coronary event. There are no established biochemical markers of acute coronary syndrome (ACS) that could be routinely employed to address the disparate risk in medically underserved populations. This issue will be addressed by a 5 yr cohort study with a nested case-control component, involving 200 subjects who are patients in the USA Health System. The patient demographic will be >40% medically underserved.
Plasma levels of two candidate biomarkers of ACS, Hsp27 and pregnancy associated protein A (PAPPA), will be assayed biannually in volunteers 45-80 years old who are being monitored for cardiovascular disease by medical staff of the Division of Cardiology. Both Hsp27 and PAPP-A are biochemical components of atherosclerotic plaque that have been proposed as prognostic biomarkers of cardiovascular risk. Hsp27 in vascular smooth muscle and endothelial cells is considered an "antiatherogenic" protein because it has anti-proliferative and anti-inflammatory effects. Hsp27 is secreted into the blood in all individuals. Levels diminish during aging and appear to be further reduced as plaque burden increases. The major goal of the study is test the predictive value of Hsp27 compared to the better established PAPP-A as a biomarker of acute coronary syndrome and overall cardiovascular risk. The project has three specific aims: 1. Make repeated measures of plasma biomarker levels over a 5 yr time span that establishes the baseline variability in the biomarkers with age, 2. Make repeated measures of the biomarkers after an acute coronary event to determine the utility of the biomarkers in predicting cardiovascular risk, and 3. Conduct assays of the biochemical state of Hsp27 to test for predictive value of phosphorylation or oligomer size in assessing cardiovascular risk. Successful completion of the study would enhance the validity of plasma Hsp27 levels and Hsp27 phosphorylation as simple noninvasive outpatient tests for cardiovascular risk assessment in medically underserved populations.
项目概述(见说明):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William T Gerthoffer其他文献
William T Gerthoffer的其他文献
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{{ truncateString('William T Gerthoffer', 18)}}的其他基金
MicroRNA regulation of airway remodeling and repair in asthma
MicroRNA对哮喘气道重塑和修复的调节
- 批准号:
9597524 - 财政年份:2017
- 资助金额:
$ 6.94万 - 项目类别:
MICRORNA REGULATION OF AIRWAY REMODELING AND REPAIR IN ASTHMA
哮喘气道重塑和修复的微小RNA调节
- 批准号:
9206437 - 财政年份:2016
- 资助金额:
$ 6.94万 - 项目类别:
MICRORNA REGULATION OF AIRWAY REMODELING AND REPAIR IN ASTHMA
哮喘气道重塑和修复的微小RNA调节
- 批准号:
9034401 - 财政年份:2016
- 资助金额:
$ 6.94万 - 项目类别:
Heat shock protein 27 (HSP27) as a marker of atherosclerosis
热休克蛋白 27 (HSP27) 作为动脉粥样硬化的标志物
- 批准号:
8609507 - 财政年份:2014
- 资助金额:
$ 6.94万 - 项目类别:
Heat shock protein 27 (HSP27) as a marker of atherosclerosis
热休克蛋白 27 (HSP27) 作为动脉粥样硬化的标志物
- 批准号:
8354210 - 财政年份:2012
- 资助金额:
$ 6.94万 - 项目类别:
Molecular determinants of smooth muscle phenotype in pulmonary hypertension
肺动脉高压平滑肌表型的分子决定因素
- 批准号:
8051637 - 财政年份:2010
- 资助金额:
$ 6.94万 - 项目类别:
Molecular determinants of smooth muscle phenotype in pulmonary hypertension
肺动脉高压平滑肌表型的分子决定因素
- 批准号:
7874178 - 财政年份:2010
- 资助金额:
$ 6.94万 - 项目类别:
COBRE: UNV MED SCH: CORE B: MOLECULAR EXPRESSION & TRANGENICS
COBRE:UNV MED SCH:核心 B:分子表达
- 批准号:
7960570 - 财政年份:2009
- 资助金额:
$ 6.94万 - 项目类别:
COBRE: UNV MED SCH: CORE B: MOLECULAR EXPRESSION & TRANGENICS
COBRE:UNV MED SCH:核心 B:分子表达
- 批准号:
7610555 - 财政年份:2007
- 资助金额:
$ 6.94万 - 项目类别:
COBRE: UNV MED SCH: CORE B: MOLECULAR EXPRESSION & TRANGENICS
COBRE:UNV MED SCH:核心 B:分子表达
- 批准号:
7382022 - 财政年份:2006
- 资助金额:
$ 6.94万 - 项目类别:
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