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George M O'Brien Kidney Center at Yale

耶鲁大学乔治·M·奥布莱恩肾脏中心

基本信息

批准号：
8326713
负责人：
PETER S. ARONSON
金额：
$ 81.14万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8326713
关键词：
Acute Renal Failure with Renal Papillary Necrosis Animal Model Animals Antibodies Applied Genetics Area Award Basic Science Biological Assay Biology Blood Vessels Canada Cell Line Cell Polarity Cell physiology Cells Cellular Structures Cellular biology Clinical Clinical Investigator Clinical Research Collaborations Communities Complex Country Development Developmental Biology Disease Disease model Electrolytes Epidemiologic Studies Epithelial Epithelial Cells Equilibrium Faculty Financial Support Fostering Functional disorder Funding Funding Agency Gene Mutation Genes Genetic Genetic Medicine Genomics Genotype Goals Grant Health Sciences Human Human Genetics Hypertension In Vitro Individual Inherited Injury Institution Instruction Internal Medicine Investigation KCNJ1 gene Kidney Kidney Diseases Knowledge Leadership Measurement Medical Students Medical center Medicine Mentors Metabolic Methods Michigan Molecular Morphogenesis Mouse Cell Line Mus Mutation Nephrology Nephrons Oregon Organism Patients Pediatrics Phenotype Physicians Physiological Physiology Positioning Attribute Postdoctoral Fellow Prevention Prize Program Research Project Grants Regulatory Pathway Renal function Renal tubule structure Research Research Institute Research Personnel Research Training Resources Scientist Services Syndrome TNFRSF5 gene Technical Expertise Techniques Technology Texas Training Training Programs Transgenic Mice Transgenic Organisms Translational Research Transport Process Universities Virginia Whole Organism authority base career cohort driving force epithelial Na+ channel familial hypertension graduate student human disease in vivo indexing interest kidney cell medical schools member mouse model new technology novel professor programs renal tubular transport translational study wasting

项目摘要

DESCRIPTION, OVERALL (provided by applicant): The overarching goal of the George M. O'Brien Kidney Center at Yale is to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases. Major themes of the Center are the development and phenotyping of mouse models of renal dysfunction, the identification of simple and complex genetic causes of kidney disease in humans, and the bidirectional exchange of information between mouse and human disease models in order to advance knowledge of human kidney diseases. A critically important benefit of the Yale Center will be to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, three Center Cores will be established whose specific objectives are to provide small animal physiology services to allow detailed characterization of renal function at the level of the tubule, the kidney, and the intact organism in normal animals and in animal models of renal injury and kidney disease; provide mouse genetics and cell line services to develop new animal models and kidney cell lines to elucidate the molecular mechanisms underlying the pathophysiology of kidney diseases; and provide human genetics and clinical research services to apply genetic and genomic technologies to the study of human kidney diseases. We have identified a research user base of 51 investigators, including 18 at outside institutions, who have expressed specific interest in using core services of the Yale Kidney Center. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of kidney disease research, and to foster translational and clinical studies directly related to kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among renal investigators participating in the Center; facilitate the application of new technologies to kidney disease research; and provide an online index of resources developed in the Center (e.g. antibodies, transgenic mouse lines, cell lines) so that they can be made available to renal investigators both at Yale and other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in kidney disease research in general, and in the specialized methods provided by the Center Cores in particular.

总体描述（由申请人提供）：