George M O'Brien Kidney Center at Yale

总体描述（由申请人提供）： 乔治M.耶鲁大学的奥布莱恩肾脏中心旨在促进转化和临床研究，以促进肾脏疾病的预防和治疗。该中心的主要主题是肾功能不全小鼠模型的开发和表型，人类肾脏疾病的简单和复杂遗传原因的鉴定，以及小鼠和人类疾病模型之间的双向信息交换，以促进人类肾脏疾病的知识。耶鲁中心的一个至关重要的好处是为耶鲁和全国各地的肾脏研究人员提供高度专业化的服务，这些服务通常无法支持他们的研究。为此，将建立三个中心核心，其具体目标是提供小动物生理学服务，以允许在正常动物和肾损伤和肾病动物模型中在肾小管、肾脏和完整生物体水平上详细表征肾功能;提供小鼠遗传学和细胞系服务，以开发新的动物模型和肾脏细胞系，阐明肾脏疾病病理生理学的分子机制;并提供人类遗传学和临床研究服务，将遗传和基因组技术应用于人类肾脏疾病的研究。我们已经确定了51名研究人员的研究用户群，其中包括18名外部机构的研究人员，他们对使用耶鲁肾脏中心的核心服务表示了特别的兴趣。将建立一个试点和可行性计划，为年轻的研究人员提供初始项目资金，吸引新的研究人员进入肾脏疾病研究领域，并促进与肾脏疾病直接相关的转化和临床研究。此外，还将建立一个丰富计划，以促进参与该中心的肾脏研究者之间的跨学科互动和合作;促进新技术在肾脏疾病研究中的应用;并提供该中心开发的资源（例如抗体，转基因小鼠系，细胞系）的在线索引，以便耶鲁大学和其他机构的肾脏研究者可以使用。该中心还将包括一个研究培训计划，以加强研究生，医学生和博士后研究员在肾脏疾病研究方面的培训，特别是中心核心提供的专业方法。

DESCRIPTION, OVERALL (provided by applicant): The overarching goal of the George M. O'Brien Kidney Center at Yale is to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases. Major themes of the Center are the development and phenotyping of mouse models of renal dysfunction, the identification of simple and complex genetic causes of kidney disease in humans, and the bidirectional exchange of information between mouse and human disease models in order to advance knowledge of human kidney diseases. A critically important benefit of the Yale Center will be to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, three Center Cores will be established whose specific objectives are to provide small animal physiology services to allow detailed characterization of renal function at the level of the tubule, the kidney, and the intact organism in normal animals and in animal models of renal injury and kidney disease; provide mouse genetics and cell line services to develop new animal models and kidney cell lines to elucidate the molecular mechanisms underlying the pathophysiology of kidney diseases; and provide human genetics and clinical research services to apply genetic and genomic technologies to the study of human kidney diseases. We have identified a research user base of 51 investigators, including 18 at outside institutions, who have expressed specific interest in using core services of the Yale Kidney Center. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of kidney disease research, and to foster translational and clinical studies directly related to kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among renal investigators participating in the Center; facilitate the application of new technologies to kidney disease research; and provide an online index of resources developed in the Center (e.g. antibodies, transgenic mouse lines, cell lines) so that they can be made available to renal investigators both at Yale and other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in kidney disease research in general, and in the specialized methods provided by the Center Cores in particular.