George M O'Brien Kidney Center at Yale

总体描述(由申请人提供)： 耶鲁大学乔治·M·奥布莱恩肾脏中心的首要目标是促进翻译和临床研究，促进肾脏疾病的预防和治疗。该中心的主要主题是开发和分型小鼠肾功能障碍模型，确定人类肾脏疾病的简单和复杂遗传原因，以及小鼠和人类疾病模型之间的双向信息交流，以促进对人类肾脏疾病的了解。耶鲁中心的一个至关重要的好处将是为耶鲁大学和全国各地的肾脏研究人员提供高度专业化的服务，而这些服务是以其他方式无法用来支持他们的研究的。为此，将建立三个中心，其具体目标是提供小动物生理学服务，以便在正常动物和肾脏损伤和肾脏疾病的动物模型中详细描述肾小管、肾脏和完整生物体的功能；提供小鼠遗传学和细胞系服务，以开发新的动物模型和肾脏细胞系，以阐明肾脏疾病病理生理学的分子机制；以及提供人类遗传学和临床研究服务，将遗传和基因组技术应用于人类肾脏疾病的研究。我们已经确定了一个由51名研究人员组成的研究用户基础，其中包括18名外部机构的研究人员，他们表达了对使用耶鲁肾脏中心核心服务的具体兴趣。将建立一个试点和可行性计划，为年轻研究人员提供初始项目资金，吸引新的研究人员进入肾脏疾病研究领域，并促进与肾脏疾病直接相关的翻译和临床研究。此外，还将建立一个丰富计划，以促进参与该中心的肾脏研究人员之间的跨学科互动和合作；促进新技术在肾脏疾病研究中的应用；并提供该中心开发的资源(例如抗体、转基因小鼠系、细胞系)的在线索引，以便耶鲁大学和其他机构的肾脏研究人员可以使用这些资源。该中心还将包括一个研究培训计划，以加强对研究生、医学生和博士后研究员在肾脏疾病研究方面的一般培训，特别是在中心核心提供的专门方法方面的培训。

DESCRIPTION, OVERALL (provided by applicant): The overarching goal of the George M. O'Brien Kidney Center at Yale is to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases. Major themes of the Center are the development and phenotyping of mouse models of renal dysfunction, the identification of simple and complex genetic causes of kidney disease in humans, and the bidirectional exchange of information between mouse and human disease models in order to advance knowledge of human kidney diseases. A critically important benefit of the Yale Center will be to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, three Center Cores will be established whose specific objectives are to provide small animal physiology services to allow detailed characterization of renal function at the level of the tubule, the kidney, and the intact organism in normal animals and in animal models of renal injury and kidney disease; provide mouse genetics and cell line services to develop new animal models and kidney cell lines to elucidate the molecular mechanisms underlying the pathophysiology of kidney diseases; and provide human genetics and clinical research services to apply genetic and genomic technologies to the study of human kidney diseases. We have identified a research user base of 51 investigators, including 18 at outside institutions, who have expressed specific interest in using core services of the Yale Kidney Center. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of kidney disease research, and to foster translational and clinical studies directly related to kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among renal investigators participating in the Center; facilitate the application of new technologies to kidney disease research; and provide an online index of resources developed in the Center (e.g. antibodies, transgenic mouse lines, cell lines) so that they can be made available to renal investigators both at Yale and other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in kidney disease research in general, and in the specialized methods provided by the Center Cores in particular.