Summer Training Course in Aging Research

暑期培训课程摘要 请提供支助，以继续举办将于2008年6月至2012年6月举行的一系列实验老龄化研究夏季培训班。为期5天的课程将由加利福尼亚州诺瓦托的巴克年龄研究所指导，会议地点将在三个主办机构之间轮换：巴克年龄研究所、圣安东尼奥的德克萨斯大学健康科学中心和西雅图的华盛顿大学。自1993年以来，类似的课程每年夏天都举办得非常成功。本课程旨在为学员提供深入接触实验生物老年学现代研究的机会，并提供关于研究思路和计划的个性化指导。每年的招生人数将限制为20名研究人员。大多数受训者将处于其职业生涯的形成阶段，但本课程也将考虑那些希望进入或将他们的努力转向老龄化研究领域的高级研究人员。每个实习生都需要在博士学位(医学博士、博士学位或医学博士学位)以外的细胞或分子生物学的某些方面拥有至少两年的生产性实验室经验。在为期5天的课程中，每天将包括3个活动：(A)2个旨在向受训者介绍老年学主要领域的背景、最新发现和主要未回答问题的“概述”讲座；(B)研究发展研讨会，每个受训者将有机会介绍他或她自己的研究想法和批评计划；以及(C)由东道主或附近机构的知名教员介绍的研究研讨会，他们通常将涵盖概述讲座中未涵盖的主题或疾病方面。这个暑期培训课程将为年轻的研究人员提供现代实验老年学的坚实基础，并为更多正在开发老龄研究新项目的资深科学家提供有用的视角。 四位科学家将担任课程指导委员会，并将定期参加课程：课程主任朱迪思·坎皮西将讨论癌症、干细胞和衰老的细胞生物学；Jan Vijg将讲授衰老的小鼠模型和基因组不稳定性；Arlan Richardson将讨论热量限制和氧化应激；Peter Rabinovich将讲授自由基和线粒体。其他14名研究人员将担任参与教师，大约每三年参加一次课程。他们包括：Andrzej Bartke(衰老内分泌学)，Brian Kennedy(无脊椎动物模型，热量限制)，Caleb Finch(神经退行性，随机性)，George Martin(早孕症，神经退行性，年龄相关疾病)，Gordon Lithgow(无脊椎动物模型，应激)，Jim Nelson(内分泌学，应激)，John Tower(无脊椎动物模型，性别决定)，Marc TTower(人口学，进化论)，Nir Barzilai(遗传变异)，Richard Miller(脊椎动物模型，免疫学)，Rita Effros(比较生物学，进化论，细胞生物学)，Steve Austad(比较生物学，进化，细胞生物学)，Tom Rando(干细胞，细胞生物学)，Lee(神经退行性)。

SUMMER TRAINING COURSE ABSTRACT Support is requested to continue a series of Summer Training Courses in Experimental Aging Research to be held in June from 2008 through 2012. The 5-day Course will be directed from the Buck Institute for Age Research in Novato, CA and the conference site will rotate among three host institutions: The Buck Institute for Age Research, the University of Texas Health Science Center at San Antonio, and the University of Washington in Seattle. Similar courses have been held with great success every summer since 1993. The Course is designed to provide trainees with intensive exposure to modern research in experimental biogerontology and individualized guidance regarding research ideas and plans. Each year's enrollment will be limited to 20 researchers. Most trainees will be in formative stages of their careers, but the Course will also consider senior investigators who wish to enter or redirect their efforts to an area of aging research. Each trainee is expected to have at least 2 years of productive laboratory experience in some aspect of cell or molecular biology beyond the doctoral degree (MD, PhD, or DVM). Each day during the 5-day program will include 3 activities: (a) 2 "overview" lectures designed to introduce trainees to the context, latest findings and main unanswered questions in a major area of gerontology; (b) a research development workshop, at which each trainee will have an opportunity to present his or her own research ideas and plans for critique; and (c) a research seminar presented by a prominent faculty member of the host or nearby institution, who will generally cover a topic or disease aspect not covered in the overview lectures. This Summer Training Course will provide younger researchers with a solid foundation in modern experimental gerontology, and provide a useful perspective to more senior scientists who are developing new programs in aging research. Four scientists will serve as the Course Steering Committee and will participate in the course on a regular basis: Judith Campisi, the Course Director, will discuss cancer, stem cells and the cell biology of aging; Jan Vijg will lecture on mouse models of aging and genome instability; Arlan Richardson will discuss on caloric restriction and oxidative stress; and Peter Rabinovich will lecture on free radicals and mitochondria. Fourteen other researchers will serve as Participating Faculty, attending the course approximately every third year. They include: Andrzej Bartke (endocrinology of aging), Brian Kennedy (invertebrate models, caloric restriction), Caleb Finch (neurodegeneration, stochasticity), George Martin (progerias, neurodegeneration, age-related disease), Gordon Lithgow (invertebrate models, stress), Jim Nelson (endocrinology, stress), John Tower (invertebrate models, sex determination), Marc Tatar (demography, evolution), Nir Barzilai (genetic variation), Richard Miller (vertebrate models, immunology), Rita Effros (immunology, cell biology), Steve Austad (comparative biology, evolution), Tom Rando (stem cells, cell biology), Virginia Lee (neurodegeneration).