Understanding and preventing breast cancer disparties in Latinas
了解和预防拉丁裔乳腺癌的差异
基本信息
- 批准号:8296079
- 负责人:
- 金额:$ 186.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2015-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAdoptionAgeBiological ProcessBreast Cancer DetectionBreast Cancer Early DetectionCaringCensusesClinicCommitCommunitiesCommunity HealthCommunity Health CentersDataDetectionDisciplineERBB2 geneEducationEffectivenessEffectiveness of InterventionsEtiologyFamilyGene ExpressionGeneticGoalsHispanicsIncidenceIndividualInflammationInterventionLatinaLatinoLifeMainstreamingMalignant NeoplasmsMammographyMedicalMedical RecordsModelingMorbidity - disease rateNeighborhoodsNot Hispanic or LatinoPamphletsPathway interactionsPatient Self-ReportPersonsPhysical activityPlanet MarsPopulationPostmenopausePrincipal InvestigatorProcessProviderRandomizedReducing dietRelative (related person)Reminder SystemsReportingResearch PersonnelResourcesRiskRisk FactorsRoleSamplingScheduleScreening procedureSeaServicesSignal PathwaySiteSocial EnvironmentStagingTelephoneTestingUninsured Medical ExpenseUnited StatesWashingtonWomanarmbasecostcost effectivenessdesignexperiencehealth disparityimprovedmalignant breast neoplasmmortalityobesity riskoutcome forecastoverexpressionpreventprogramssocialsuccesstreatment as usualtumoruptake
项目摘要
DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among Hispanic women in the United States (US). The incidence of breast cancer among Hispanics (83.5 per 100,000) is lower than that among non-Hispanic Whites (147.3 per 100,000); however, as Hispanic women adopt the practices of mainstream US culture, their risk for breast cancer increases. Further, Hispanic women are at increased risk for breast cancers with poor prognosis. The overarching theme of this PSO application is to understand and prevent pre-cursors of breast cancer and to reduce breast cancer morbidity and mortality among Latinas. This will be done at multiple levels and will engage researchers across several disciplines. Projects have been carefully designed to contribute understanding to and preventing breast cancer in Latinas. It is the lonq-term goal of this PSO application to understand the antecedents of breast cancer in the Latina population, to understand the types of breast cancer found in the Latina population, and develop and implement a comprehensive program of screening to increase the opportunities for early breast cancer detection among Latinas. Our short-term obiectives are to:
1. Increase breast cancer screening among age-eligible Latinas;
2. Understand the processes by which ancestry, BMI, inflammation, and breast cancer are related in Latinas
3. To understand aspects of the etiology of poor prognosis breast cancers by identifying risk factors related to triple negative (TN) and HER-2-overexpressing (H2E) tumors, which are more commonly found in Latinas compared to non-Hispanic whites
4. To understand the role of ancestry in breast cancer antecedents and incidence among Latinas.
5. To explore expression of genes involved in tumor-related pathways signaling. This application is committed to a comprehensive multi-level approach to reducing health disparities. Its projects range from the biologic and genetic to the social context within which people live. Through its four projects and cores, the proposed Center will cover a myriad of aspects of breast cancer, from biological processes and genetic pathways to individual determinants and social determinants of breast cancer.
描述(由申请人提供):乳腺癌是美国 (US) 西班牙裔女性中最常见的癌症。西班牙裔乳腺癌发病率(每 10 万人中 83.5 例)低于非西班牙裔白人(每 10 万人中 147.3 例);然而,随着西班牙裔女性接受美国主流文化的做法,她们患乳腺癌的风险就会增加。此外,西班牙裔女性患乳腺癌的风险增加,且预后较差。该 PSO 应用程序的首要主题是了解和预防乳腺癌的前兆,并降低拉丁裔乳腺癌的发病率和死亡率。这将在多个层面上完成,并将吸引多个学科的研究人员参与。项目经过精心设计,旨在促进对拉丁裔乳腺癌的了解和预防。该 PSO 应用程序的长期目标是了解拉丁裔人群中乳腺癌的前因,了解拉丁裔人群中发现的乳腺癌类型,并制定和实施全面的筛查计划,以增加拉丁裔人群中早期乳腺癌检测的机会。我们的短期目标是:
1. 增加对符合年龄的拉丁裔的乳腺癌筛查;
2. 了解拉丁裔血统、体重指数、炎症和乳腺癌的相关过程
3. 通过识别与三阴性 (TN) 和 HER-2 过表达 (H2E) 肿瘤相关的危险因素来了解预后不良乳腺癌的病因学,与非西班牙裔白人相比,三阴性 (TN) 和 HER-2 过表达 (H2E) 肿瘤在拉丁裔中更常见
4. 了解血统在拉丁裔乳腺癌前因和发病率中的作用。
5. 探讨肿瘤相关通路信号相关基因的表达。该应用程序致力于采用全面的多层次方法来减少健康差异。其项目范围从生物学和遗传学到人们生活的社会背景。通过其四个项目和核心,拟建中心将涵盖乳腺癌的各个方面,从生物过程和遗传途径到乳腺癌的个体决定因素和社会决定因素。
项目成果
期刊论文数量(0)
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8744900 - 财政年份:2013
- 资助金额:
$ 186.24万 - 项目类别:
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