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The Role of Hippo Pathway in Liver Regeneration

The Role of Hippo Pathway in Liver Regeneration
Hippo 通路在肝脏再生中的作用
批准号：
8281684
负责人：
ROBERT A. ANDERS
金额：
$34.16万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-06-10 至 2013-05-31
来源：
https://reporter.nih.gov/project-details/8281684
关键词：
AbbreviationsAcuteAcute HepatitisAddressAlanine TransaminaseApolipoprotein EApoptosisBromodeoxyuridineCMV promoterCause of DeathCell CycleCell DeathCell divisionCessation of lifeChronic HepatitisCirrhosisComplementary DNACyclin-Dependent KinasesCyclinsDNA biosynthesisDataDefectDeoxyuridineDevelopmentDiseaseEngineeringGene ExpressionGenesGoalsGrowthHealthHepatocarcinogenesisHepatocyteHepatocyte Growth FactorHepatomegalyKnockout MiceLeadLinkLiverLiver RegenerationLiver diseasesMediatingModelingMolecularMorbidity - disease rateMusNOS2A geneNitric OxidePartial HepatectomyPathway interactionsPhysiological ProcessesPositioning AttributeProcessProductionProliferating Cell Nuclear AntigenProteinsProto-Oncogene Protein c-metResistanceResponse ElementsRoleSignal TransductionSystemTetracyclinesTransgenic MiceTumor Suppressor ProteinsUnited StatesWorkburden of illnesschronic liver diseaseimprovedin vivoin vivo Modelinhibitor/antagonistliver cell proliferationliver transplantationmeetingsnew therapeutic targetnovelpreventpro-hepatocyte growth factorpromoterregenerative

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Liver diseases are among the 10 leading causes of death in the United States. The liver's extraordinary regenerative capacity is critical to understanding the mechanisms leading to developmental defects, acute and chronic liver diseases, and liver carcinogenesis. Stimulation of hepatocyte proliferation while preventing apoptosis is essential to the liver's regenerative process. Recently we uncovered a tumor suppressor pathway has potent effects upon liver cell division and death. Our long range goal is to define the cellular mechanisms underlying liver regeneration in health and disease and to apply these findings to developing improved therapies for liver disease. To that end, we are uniquely capable to address the objectives of this application, which are to uncover the mechanism that leads to the novel tumor suppressors' profound effects upon the liver. The central hypothesis of this proposal is that: The tumor suppressor controls liver celgrowth factor pathway in controlling liver size. At the end of the study we will better understand the growth and death of liver cells. This will help develop treatment for many liver diseases such as liver transplantation, cirrhosis, acute and chronic hepatitis. Project Narrative: The objectives of this study are to uncover a newly recognized very potent molecular system that controls the growth and death of the liver cells. Unlocking how this pathway works will help develop treatment for many liver diseases such as liver transplantation, cirrhosis, acute and chronic hepatitis.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings.
儿科兄弟姐妹中八叠球菌微生物和幽门螺杆菌胃炎/十二指肠炎的共存。
DOI： --
发表时间： 2013
期刊： Journal of clinical & anatomic pathology (JCAP)
影响因子： --
作者： [Sauter,JenniferL, Nayar,SureshK, Anders,PaigeD, D'Amico,Michael, Butnor,KellyJ, Wilcox,RebeccaL]
通讯作者： Wilcox,RebeccaL
Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway.
缺氧诱导因子 2 α 通过转录因子二聚化伴侣 3/E2F 转录因子 1 依赖性细胞凋亡途径抑制肝细胞癌生长。
DOI： 10.1002/hep.26188
发表时间： 2013-03
期刊： HEPATOLOGY
影响因子： 13.5
作者： [Sun, Hai-Xiang, Xu, Yang, Yang, Xin-Rong, Wang, Wei-Min, Bai, Haibo, Shi, Ruo-Yu, Nayar, Suresh K., Devbhandari, Ranjan P., He, Yi-zhou, Zhu, Qin-Feng, Sun, Yun-Fan, Hu, Bo, Khan, Mehtab, Anders, Robert A., Fan, Jia]
通讯作者： Fan, Jia
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.
DOI： 10.1016/j.devcel.2010.06.015
发表时间： 2010-07-20
期刊： DEVELOPMENTAL CELL
影响因子： 11.8
作者： [Zhang, Nailing, Bai, Haibo, David, Karen K., Dong, Jixin, Zheng, Yonggang, Cai, Jing, Giovannini, Marco, Liu, Pentao, Anders, Robert A., Pan, Duojia]
通讯作者： Pan, Duojia
Yes-associated protein regulates the hepatic response after bile duct ligation.
DOI： 10.1002/hep.25769
发表时间： 2012-09
期刊： HEPATOLOGY
影响因子： 13.5
作者： [Bai, Haibo, Zhang, Nailing, Xu, Yang, Chen, Qian, Khan, Mehtab, Potter, James J., Nayar, Suresh K., Cornish, Toby, Alpini, Gianfranco, Bronk, Steven, Pan, Duojia, Anders, Robert A.]
通讯作者： Anders, Robert A.
共 8 条
    Core D: Digital Pathology and CyTOF
    • 批准号：
      10408089
    • 项目类别：
    • 资助金额：
      $34.28万
    • 财政年份：
      2021
    • 负责人：
      ROBERT A. ANDERS
    • 依托单位：
      JOHNS HOPKINS UNIVERSITY
    Core D: Digital Pathology and CyTOF
    • 批准号：
      10661816
    • 项目类别：
    • 资助金额：
      $34.22万
    • 财政年份：
      2021
    • 负责人：
      ROBERT A. ANDERS
    • 依托单位：
      JOHNS HOPKINS UNIVERSITY
    Pathology Core
    • 批准号：
      10093985
    • 项目类别：
    • 资助金额：
      $12.93万
    • 财政年份：
      2019
    • 负责人：
      ROBERT A. ANDERS
    • 依托单位：
      JOHNS HOPKINS UNIVERSITY
    Pathology Core
    • 批准号：
      10356012
    • 项目类别：
    • 资助金额：
      $11.17万
    • 财政年份：
      2019
    • 负责人：
      ROBERT A. ANDERS
    • 依托单位：
      JOHNS HOPKINS UNIVERSITY
    海外基金